Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols

Design, Synthesis, Molecular Docking, and In Vitro Antibacterial Evaluation of Benzotriazole-Based β-Amino Alcohols and Their Corresponding 1,3-Oxazolidines

“…The major objective of this work was to improve benzotriazole chemistry , in order to create various types of β-amino alcohol analogues with 1,2,3-benzotriazole as the main heterocyclic component (for antibacterial screening, etc.). There are few reports in the literature that demonstrates the antibacterial activity of β-amino alcohols. − Therefore, to create medicinally advantageous antibacterial benzotriazole β-blocker analogues 4 and their equivalent oxazolidines 5 , a well-planned retrosynthetic technique was used to introduce a powerful β-amino alcohol unit into the benzotriazole nucleus (Scheme ).…”

“…In light of the aforementioned biological applications, the benzotriazole moiety has been frequently used to construct biologically potent molecules which not only imparts significant properties like hydrophilicity, lipophilicity, and minimal side effects but also enhances their bioactivities. − Additionally, this will help to curb the drug-resistant pathogens, which will boost the prospects of developing superior drug alternatives. , On the other hand, β-amino alcohols are an elite class of compounds that have a wide range of medicinal applications. − Additionally, they were extensively used in the synthesis of unnatural amino acids , as well as in asymmetric synthesis such as chiral ligands and auxiliaries. , Therefore, it is anticipated that the addition of a biologically active β-amino alcohol moiety to a benzotriazole scaffold will complement their action, perhaps improving the total pharmacological activity. It is important to note that screening of powerful and hybrid heterocycles has developed into a modern trend in biomedical development programs. − …”

Unprecedented Convergent Synthesis of Sugar-Functionalization of Phosphinic Acids under Metal-Free Conditions

“…1,2,3,4-Tetra-O-acetyl-6-O-trityl-β-D-glucopyranose (18). 27 The title compound was prepared from 6-O-trityl-Dglucopyranose 17 according to a general procedure. 27 The airdried product was then introduced into Et 2 O, and the less soluble β-isomer was isolated and recrystallized from hot EtOH.…”

“…27 The title compound was prepared from 6-O-trityl-Dglucopyranose 17 according to a general procedure. 27 The airdried product was then introduced into Et 2 O, and the less soluble β-isomer was isolated and recrystallized from hot EtOH. Upon cooling, white crystals of 18 were liberated.…”

SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES STUDIES OF N-{2-(4-Chlorophenyl) ACETYL} AMINO ALCOHOLS DERIVED FROM Α-Amino ACIDS

“…Peptides have been displayed properties that control the biological functions of other proteins and also antagonism towards pathogenic microorganisms; such peptides commonly have been used as therapeutic agents due to their behavior as peptidomimetics or enzyme inhibitors. [1][2][3] There are many simple amino alcohol derivatives exhibited various biological activities such as antitumor [4] and antibacterial. [5] Lipidic amino alcohol derivatives and their metal complexes showed good anticarcinogenic, immune suppressor, anti-inflammatory, and analgesic [6] properties.…”