Solitary Fibrous Tumor of Central Nervous System: A Case Report

Abstract

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin, especially in the central nervous system (CNS). Reported herein is a case of SFT of CNS in a 63-year-old female patient who had confused mentality, without other neurological deficit. The brain MRI showed an ovoid mass in the right frontal lobe. The tumor was surgically removed grossly and totally, and the pathologic diagnosis was SFT. At 55 months after the surgery, the tumor recurred at the primary site and at an adjacent area. A second operation was thus done, and the tumor was again surgically removed grossly and totally. The pathologic diagnosis was the same as the previous, but the Ki-67 index was elevated. Ten months later, two small recurring tumors in the right frontal skull base were found in the follow-up MRI. It was decided that radiation therapy be done, and MRI was done again 3 months later. In the follow-up MRI, the size of the recurring mass was found to have decreased, and the patient did not manifest any significant symptom. Follow-up will again be done 18 months after the second surgery.

Solitary fibrous tumor of the pineal region with delayed ectopic intracranial metastasis: A case report and review of the literature

“…[15] (Solitary fibrous tumors of the central nervous system: clinicopathological and therapeutic considerations of 18 cases) On immunohistochemistry, SFTs are characterized by diffusive staining of CD34, vimentin, CD99 and Bcl-2, while always negative for S-100 and EMA expression, which can be easily distinguished from meningioma. [2,16,17] Negative CD34 as in our case, however, has been reported and considered as a potential indicator of poor prognosis. [5,12,18,19]…”

Extremely rare case of intravascular solitary fibrous tumour in the inferior vena cava with review of the literature

“…However, the incidence of extrapleural SFT (ESFT) has been increasing within the last two decades, and approximately more than one-third of literature in English is about ESFTs [9]. Such tumour has been observed at almost every extrapleural anatomic site, including the liver [10], kidney [11], pancreas [12], prostate [13], breast [14], central nervous system [15], reproductive system [16, 17], orbit [18], head and neck [19], pelvis [20], soft tissues in the extremities [21] and retroperitoneum [22]. However, the incidence of intravascular SFT is extremely rare [23].…”

<p>Spinal Intramedullary Solitary Fibrous Tumor: A Rare and Challenging Diagnosis</p>

“…The natural history and biological behavior of SFTs are as yet unclear, and there appears to be a variation in tumor growth rates and recurrence;1,2,4,6,7,16,22–24 however, it usually has an indolent course as reflected in the WHO classification of the tumors of the central nervous system. According to the 2007 classification criteria, SFT was classified as an independent benign pathological variation corresponding to grade I 25.…”

“…Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm of putative fibroblastic origin. They can occur anywhere in the human body but arise predominantly in the visceral pleura; SFTs in extraserosal sites, especially those involving the central nervous system, are quite infrequent 1–3. SFTs occurring in the spinal intramedullary locations are extremely rare 4–8.…”