Extremely rare case of intravascular solitary fibrous tumour in the inferior vena cava with review of the literature

Abstract

Background Solitary fibrous tumour (SFT) is a mesenchymal tumour of fibroblastic type, and it develops in almost any part of the human body. However, according to previous studies, the occurrence of intravascular SFTs is extremely rare. Case presentation We reported a case of intravascular SFT in a 67-year-old woman who has been experiencing swelling and pain in the right leg for 2 months. Computed tomography venography scan revealed a well-defined mass obstructing the inferior vena cava (IVC). Surgical resection was performed, and histopathologic and immunohistochemical results were consistent with SFT. Further, next-generation sequencing (NGS) analysis was performed, and results revealed two tumour-related gene mutations (deletion of PMS2 and variation of ESR1 [L536P]). The patient did not receive any adjuvant therapy, and no signs of tumour progression were observed during the 6-month follow-up. Conclusion To the best of our knowledge, this study first presented about SFT arising from the IVC and carried out an NGS analysis to validate the molecular mechanism of such condition.

Soliter fibrous tumor of diaphragm in a patient with larynx cancer: Case report

“…SFT is a rare type of neoplasm of mesenchymal origin, but especially mostly originated from the submesothelial SFTs are predominantly observed in middle-aged men and women, with no signi icant sex predilection [3]. Nevertheless, most tumors are benign, but minority of cases might have aggressive behaviors, such as local recurrence and metastasis [3]. SFTs has been observed at almost every extra pleural anatomic site, including the liver, kidney, pancreas, prostate and breast [3].…”

“…Nevertheless, most tumors are benign, but minority of cases might have aggressive behaviors, such as local recurrence and metastasis [3]. SFTs has been observed at almost every extra pleural anatomic site, including the liver, kidney, pancreas, prostate and breast [3]. Even though video-thoracoscopy approaches were enhanced, still one of the ports had to be enlarged due to size of tumors.…”

Cellular solitary fibrous tumor in the mental area: a case report and literature review

“…Other studies have also supported the observation that the biological behavior of SFTs is not strictly dependent on tumor size and mitotic count; thus, even SFTs that are considered benign based on histology may aggressively recur. 25 The gold standard treatment for SFTs is surgical resection. 26 Demicco et al 26 analyzed 110 patients with SFTs after surgery and reported that the overall 5-and 10-year patient survival rates were 89% and 73%, respectively.…”

“…Other studies have also supported the observation that the biological behavior of SFTs is not strictly dependent on tumor size and mitotic count; thus, even SFTs that are considered benign based on histology may aggressively recur. 25…”

An updated genome-scale metabolic network reconstruction ofPseudomonas aeruginosaPA14 to characterize mucin-driven shifts in bacterial metabolism

“…Elucidating the metabolic responses of P. aeruginosa to mucins can enable the development of protective approaches against infection 8 . Genome-scale metabolic network reconstructions (GENREs) and associated genome-scale metabolic models (GEMs) are well suited for this purpose as they can enable the prediction of cellular behavior under different biological conditions such as the absence or presence of different mucins in an environment 9 . A GENRE can also be used to contextualize high-throughput data, such as transcriptomics or proteomics data 10 .…”