Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis?

Öz, İbrahim İlker; Yucel, Murat; Bilici, Muammer; Şerifoğlu, İsmail; Sayın, Raşit; İlikhan, Sevil Uygun; Açıkgöz, Mustafa

doi:10.1016/j.jstrokecerebrovasdis.2015.10.012

Cited by 22 publications

(20 citation statements)

References 36 publications

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“…Seventeen results of the 27 studies revealed that patients with stroke had higher MPV than controls [10,12,25,27,28,34,35,39,41-43, [46][47][48]50]. Ten studies found no difference in MPV between patients and controls [14,15,28,29,35,36,38,45,49], and two studies demonstrated a higher MPV in the control group (Table I, Supplementary Table VI) [13,40]. The mean MPV for all publications was 9.8 fL (95% CI 9.4-10.1) for patients and 9.2 fL (95% CI, 8.8-9.6) for controls.…”

Section: Mpvmentioning

confidence: 99%

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

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Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD) = − 0.30, (95% CI: − 0.49 to − 0.11), N = 2492, P = .002] compared with controls (N = 3615). The MPV was significantly higher [SMD = 0.52 (95% CI: 0.28-0.76), N = 2739, P < .001] compared with controls (N = 3810). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD = −0.18, 95% CI: −0.35-0.01) and hemorrhagic stroke (−0.94, −1.62 to −0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (−0.36, −0.68 to −0.04). Ischemic stroke patients had higher MPV (0.57, 0.31-0.83), and samples by Ethylenediaminetetraacetic acid (EDTA) anticoagulant showed significantly higher result for patients compared to controls (0.86, 0.55--1.17). PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. These characteristics might be related to AS and associated with it. It is advisable to pay attention to elapsed time between phlebotomy and hematology analysis, anticoagulant and hemocytometer types in AS. Systematic review registration: This meta-analysis is registered on the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42017067864 (https:// www.crd.york.ac.uk/prospero/display_record.php?RecordID=67864).

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Section: Mpvmentioning

confidence: 99%

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Sadeghi

Sándor

Zsóri³

et al. 2019

Platelets

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“…5,6 Activated platelets aggregate at sites of damaged endothelial cells and participate in the development of atherosclerotic lesions, which ultimately leads to intracranial bloodstream interruption by arterial thrombosis arising from plaque rupture. [7][8][9] Many investigators have elucidated that higher mean platelet volumes (MPVs) imply severer stroke and worse prognosis, [10][11][12] whereas lower platelet counts (PLTs) are presented in AIS patients, and platelets are largely expended with the formation and development of thrombosis. 13,14 White blood cells (WBCs) are also implicated in the pathophysiology of ischemic vascular disease.…”

Section: Introductionmentioning

confidence: 99%

Platelet-to-White Blood Cell Ratio: A Prognostic Predictor for 90-Day Outcomes in Ischemic Stroke Patients with Intravenous Thrombolysis

Chen

Huang

et al. 2016

Journal of Stroke and Cerebrovascular Diseases

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“…In a study conducted by Farah and Samra (13) in 2018, no association was found between MPV values of stroke patients and development risk of a new stroke attack. In the study with 136 participants by Oz et al (14), it was found that MPV has no value in predicting the development of a cerebrovascular event in coronary artery disease. In addition, a previous study which compared MPV values of 70 first time atherothrombotic acute ischemic stroke patients, 50 transient ischemic attack patients, and 70 healthy individuals, no statistically significant difference was found between the groups (15).…”

Section: Discussionmentioning

confidence: 97%

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Demir¹

2019

BMB

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Stroke is a rapid onset of focal or global loss of cerebral function and is the most common cause of mortality and morbidity in adulthood cancer and heart disease patients. Although it has been reported that mean platelet volume (MPV) values may be an independent risk factor for the severity and prognosis of stroke, the results of previous studies are inconsistent. The aim of the present study was to determine the MPV values of ischemic stroke patients which reflects the activity and function of platelets and to observe its effect on clinical outcomes. Method: Sixty-two acute ischemic stroke patients were recruited for the study. Clinical information, MPV, platelet, white blood cell (WBC) and neutrophil, CRP and troponin-T levels were obtained. Results: The mean ± standard deviation age was 72.4±12.6 years. At the end of the study, 28 patients were discharged and 34 patients passed away. The frequency of bilateral stroke was higher in deceased patients (p=0.005). In addition, platelet counts were significantly higher in discharged patients (p=0.016). At first admission, MPV values were 10.59±1.01 fL in discharged patients and 11.29±1.12 fL in deceased patients (p=0.029). At the end of the study, MPV values were measured as 11.46±1.28 fL in deceased patient sand 10.47±0.74 fL in discharged patients (p<0.001). WBC and neutrophil counts, troponin-T and CRP values were not significantly different between deceased and discharged patients (p>0.05). Conclusion: Our study indicated that MPV and platelet levels may be associated with mortality in acute ischemic stroke patients and can be used as prognostic markers.

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Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis?

Cited by 22 publications

References 36 publications

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis

Platelet-to-White Blood Cell Ratio: A Prognostic Predictor for 90-Day Outcomes in Ischemic Stroke Patients with Intravenous Thrombolysis

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

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