Platelet-to-White Blood Cell Ratio: A Prognostic Predictor for 90-Day Outcomes in Ischemic Stroke Patients with Intravenous Thrombolysis

Chen, Zhibo; Huang, Yuanyuan; Li, Shanshan; Lin, Jie; Liu, Wenyue; Ding, Zhangna; Li, Xiang; Chen, Ying; Pang, Wanhui; Yang, Dehao; Su, Zhongqian; Li, Jia; Weng, Yiyun; Zhang, Xu

doi:10.1016/j.jstrokecerebrovasdis.2016.06.015

Cited by 30 publications

(33 citation statements)

References 43 publications

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“…It has been proved in many previous studies that the ratio of immune cells (for example, the NE/WBC ratio, PLT/WBC) in the peripheral blood may serve as inexpensive and reproducible biomarkers. Increasing evidences indicated that peripheral blood PLT/WBC ratio may serve as a biomarker for the early diagnosis, evaluation of the therapeutic efficacy, and prognosis of many diseases . In the present study, the PLT/WBC ratio of different groups was calculated, and we observed that the PLT/WBC was significantly increased in HCA group compared with non‐HCA group ( P < 0.01); next, results of ROC analysis indicated that the AUC of PLT/WBC was 0.744, suggesting that PLT/WBC is a sensitive biomarker for the diagnosis of HCA.…”

Section: Discussionsupporting

confidence: 53%

“…Some previous studies demonstrated that neutrophil‐to‐lymphocyte ratio of the patients was associated with the diagnosis and outcome of different diseases, including acute cerebrovascular diseases . On the other hand, the neutrophil‐to‐white blood cell ratio (NE/WBC) or platelet‐to‐white blood cell ratio (PLT/WBC) was significantly increased in patients with different type of diseases, for example, cancer, cardiovascular disease, and autoimmune diseases, suggesting that either NE/WBC or PLT/WBC may serve as novel biomarkers for the early diagnosis of those diseases …”

Section: Introductionmentioning

confidence: 99%

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Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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Background Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective To investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. Methods A total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. Results The neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively. Conclusion Platelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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“…As a result, PWR might be decreased in patients with HBV infection. Previous studies also had shown that PWR was a prognostic predictor for 90-day outcomes in ischemic stroke patients with intravenous thrombolysis [ 6 ]. Moreover, our study had suggested that there was a correlation between PWR and the severity of liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet to white blood cell ratio (PLT/WBC) refers to a hematologic marker of the systemic inflammatory response. Recently, PWR has been validated not only to forecast risk of infectious complications in patients undergoing radical nephrectomy for renal malignancy, but also to predict outcomes in ischemic stroke patients with intravenous thrombolysis [ 5 , 6 ]. In addition, PWR is a reliable infectious indicator that even could differentiate between infection and the normal response after splenectomy for trauma [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure

Jie

Gong

Xiao

et al. 2018

BioMed Research International

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Background. Platelet to white blood cell ratio (PWR) was an independent prognostic predictor for outcomes in some diseases. However, the prognostic role of PWR is still unclear in patients with hepatitis B related acute-on-chronic liver failure (ACLF). In this study, we evaluated the clinical performances of PWR in predicting prognosis in HBV-related ACLF. Methods. A total of 530 subjects were recruited, including 97 healthy controls and 433 with HBV-related ACLF. Liver function, prothrombin time activity (PTA), international normalized ratio (INR), HBV DNA measurement, and routine hematological testing were performed at admission. Results. At baseline, PWR in patients with HBV-related ACLF (14.03 ± 7.17) was significantly decreased compared to those in healthy controls (39.16 ± 9.80). Reduced PWR values were clinically associated with the severity of liver disease and the increased mortality rate. Furthermore, PWR may be an inexpensive, easily accessible, and significant independent prognostic index for mortality on multivariate analysis (HR = 0.660, 95% CI: 0.438–0.996, p = 0.048) as well as model for end-stage liver disease (MELD) score. Conclusions. The PWR values were markedly decreased in ACLF patients compared with healthy controls and associated with severe liver disease. Moreover, PWR was an independent prognostic indicator for the mortality rate in patients with ACLF. This investigation highlights that PWR comprised a useful biomarker for prediction of liver severity.

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“…The reason may be: (1) the effect of dehydration on long‐term prognosis was determined in the present study, while the effect on short‐term prognosis in other studies; (2) thrombolysed patients with acute cerebral infarction are subjects in the present study, who are different from patients with acute cerebral infarction in other studies; (3) BUN/Cr ≥ 15 combined with USG > 1.010 was used as a marker of dehydration status in our study, while either of them as a marker in other studies; (4) mRS 0–2 was used as a good outcome in the present study, while mRS ≤ 1 was defined as a good outcome in other studies (Cappellari et al., 2013; Song et al., 2017; Tsivgoulis et al., 2016). Different mRS cut‐offs were used as good outcome in previous study, for example, mRS ≤ 1 in some studies (Cappellari et al., 2013; Song et al., 2017; Tsivgoulis et al., 2016) and mRS 0–2 in other studies (Chen et al., 2016; Neidert et al., 2016). …”

Section: Discussionmentioning

confidence: 99%

Dehydration is a strong predictor of long‐term prognosis of thrombolysed patients with acute ischemic stroke

Yin

Zhou

et al. 2017

Brain and Behavior

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Background and PurposeDehydration was found to be involved in the poor prognosis of patients with acute ischemic stroke. It is unclear whether dehydration status before onset is related with prognosis of thrombolysed patients with acute ischemic stroke. If it is the case, quickly hydrating may improve the prognosis. The present study was designed to explore the issue.MethodsEligible 294 patients with acute ischemic stroke after thrombolysis were enrolled in the present study according to inclusion/exclusion criteria. According to the modified Rankin scale (mRS) 90 days post stroke, the patients were divided into two groups: mRS 0–2 (n = 191) and mRS 3–6 (n = 103). In the present study, BUN/Cr ≥ 15 combined with USG > 1.010 or either of them were chosen as dehydration marker. Clinical data were analyzed between two groups. Univariate and multivariate statistical analyses were carried out.ResultsAge, fibrinogen, blood glucose, BUN/Cr, NIHSS score at admission, the systolic blood pressure (SBP) before thrombolysis, dehydration status (BUN/Cr ≥ 15 plus USG > 1.010), hyperlipidemia, USG and D‐dimer on admission day, and TOAST classification showed significant difference between two groups (p < .05). Further stratification analysis showed that BUN/Cr ≥ 15, NIHSS ≥ 6, blood glucose ≥8, and SBP > 150 were markedly associated with poor outcome (mRS 3–6, p < .05). After adjusting for age, fibrinogen, USG, D‐dimer, dehydration status, NIHSS, blood glucose, SBP, hyperlipidemia, and BUN/Cr at admission, multivariate logistic regression showed that dehydration status, higher NIHSS, higher blood glucose, and higher SBP at admission were independent risk factors for predicting the long‐term poor prognosis of thrombolysed patients.ConclusionsThe present findings suggest that BUN/Cr ≥ 15 combined with USG > 1.010 as a marker of dehydration status was an independent risk factor for long‐term poor prognosis of thrombolysed patients with acute ischemic stroke.

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Platelet-to-White Blood Cell Ratio: A Prognostic Predictor for 90-Day Outcomes in Ischemic Stroke Patients with Intravenous Thrombolysis

Cited by 30 publications

References 43 publications

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure

Dehydration is a strong predictor of long‐term prognosis of thrombolysed patients with acute ischemic stroke

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