Development of significant disordered eating in an adolescent following gastric bypass surgery

Sondike, Stephen B.; Pisetsky, Emily M.; Luzier, Jessica

doi:10.1007/s40519-015-0230-z

Cited by 5 publications

(4 citation statements)

References 25 publications

(24 reference statements)

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“…Nesses estudos de avaliação, o número de pacientes (excluindo-se o estudo de caso) variou de 22 a 2.266 23,47 , com maioria feminina (26%-100%). Um era qualitativo (com questões elaboradas pelos autores e autorrelato) 28 , quatro eram de revisão (não incluídos na Tabela 2) 8,48-50 , e sete eram estudos de casos 15,16,[51][52][53][54][55] .…”

Section: Resultsunclassified

“…Há também relato de desenvolvimento de BN dois anos após CB 51 em paciente que negou vômito antes, mas após apresentou uso de laxantes, jejuns, restrição alimentar, e vômitos cinco vezes ao dia por dois anos (atingindo IMC 16,2 kg/m²). E há descrição de diagnóstico completo de BN em paciente que iniciou compulsão e vômito autoinduzido três meses após CB, cuspindo o alimento e extremamente rígido com a comida aos 12 meses; aos 24 meses evitava comer em público e apresentava isolamento social, ansiedade, depressão e reganho de peso 54 .…”

Section: Resultsunclassified

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Cirurgia bariátrica e transtornos alimentares: uma revisão integrativa

Novelle

Alvarenga

2016

J. bras. psiquiatr.

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RESUMOObjetivo: Realizar revisão sobre transtornos alimentares e comportamentos alimentares transtornados relacionados à cirurgia bariátrica. Métodos: Revisão integrativa da literatura nas bases de dados PubMed, Lilacs, Bireme, portal SciELO com descritores indexados com critérios de inclusão: oferecer dado sobre a presença ou frequência de transtorno alimentar e/ou comportamentos alimentares disfuncionais previamente e/ou após a cirurgia. Resultados: Foram selecionados 150 estudos (14 nacionais e 136 internacionais): 80,6% eram com avaliação de pacientes pré-/pós-cirúrgicos; 12% eram estudos de caso e 7,3% eram estudos de revisão. Diferentes instrumentos foram usados para avaliação, principalmente o Questionnaire on Eating and Weight Patterns, a Binge Eating Scale e Eating Disorders Examination Questionnaire. A compulsão alimentar foi o comportamento mais avaliado, com frequências/prevalências variando de 2% a 94%; no caso do transtorno da compulsão alimentar as fre quências/ prevalências variaram de 3% a 61%. Houve também a descrição de anorexia e bulimia nervosa, síndrome da alimentação noturna e comportamento beliscador. Alguns estudos apontam melhora dos sintomas no pós-cirúrgico e/ou seguimento enquanto outros apontam surgimento ou piora dos problemas. Conclusão: Apesar da variabilidade entre métodos e achados, comportamentos alimentares disfuncionais são muito frequentes em candidatos à cirurgia bariátrica e podem ainda surgir ou piorar após a intervenção cirúrgica. Profissionais de saúde devem considerar de maneira mais cuidadosa tais problemas neste público, dadas às consequências para o resultado cirúrgico e qualidade de vida. ABSTRACT Objective: To conduct a revision about disordered eating and eating disorders related to bariatric surgery. Methods: Integrative literature's review on databases PubMed, Lilacs, Bireme, portal SciELO using indexed keywords; inclusion criteria was provide data about the presence or frequency of eating disorders or disordered eating behaviors previously and/or after surgery. Results: One hundred and fifty studies were selected (14 in Brazil and 136 other countries): 80.6% were evaluation of patient's pre or post-surgery; 12% were case studies and 7.3% were revision studies. Diverse scales and questionnaires were used for evaluation, mostly the Questionnaire on Eating and Weight Patterns, the Binge Eating Scale and the 263 REVISÃO DE LITERATURA J Bras Psiquiatr. 2016;65(3):262-85. Cirurgia bariátrica e transtornos alimentaresEating Disorders Examination Questionnaire. Binge eating was the most common behavior evaluated, with frequencies/prevalence from 2% to 94%; for Binge Eating Disorder frequencies/prevalence's range from 3% to 61%. Studies also describe anorexia and bulimia nervosa, night eating syndrome and grazing. Some studies point improvement of symptoms while others call attention for the emergence or aggravation of problems. Conclusion: Despite the variability among methods and results, the presence of disordered eating behaviors is highly frequent among bariatric ...

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Section: Resultsunclassified

Cirurgia bariátrica e transtornos alimentares: uma revisão integrativa

Novelle

Alvarenga

2016

J. bras. psiquiatr.

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“…[21][22][23] Despite the contribution of nanotechnology to the development of new cancer treatments, [24] and the recent advances in cancer immunotherapies, the use of delivery carriers targeting the MDSC compartment is still in its infancy. Of note, the majority of such nanotechnological approaches rely on poorly defined semi-synthetic immunogenic structures [25][26][27][28][29] or aim to evaluate the effect of classical chemotherapeutic agents on the MDSC subset. [30][31][32] More sophisticated strategies have been explored to target tumor-associated macrophages (TAMs), [33] however, compared to the unequivocal tumor-promoting activity of MDSCs, TAMs can exert either tumor-promoting or anti-tumor effects.…”

Section: Introductionmentioning

confidence: 99%

Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells

Ledo

Sasso

Bronte

et al. 2019

Journal of Controlled Release

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Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of efficient drug delivery vehicles targeting this cell compartment. The objective of this work was to develop a delivery carrier, multilayer polymer nanocapsules, with the capacity to co-encapsulate two types of immunomodulatory drugs, a chemokine and an RNAi sequence, aimed at reverting MDSC-mediated immunosuppression. The chemokine CCL2, intended to attract monocyte-macrophage MDSCs, was encapsulated within the L2 inverse micellar aqueous domains of the lipid core of these nanocapsules. On the other hand, two different RNAi sequences that modulate the CCAAT/enhancer-binding protein beta (C/EBPβ) pathway, shC/EBPβ and miR 142-3p, were successfully associated to their polymer shell. These RNAi sequences were covered by subsequent layers of polyarginine and hyaluronic acid, thereby creating multi-layered assemblies that protected them and facilitated their targeted delivery. The in vitro studies performed in primary MDSCs cultures showed the capacity of miR 142-3p-loaded nanocapsules to reduce the highly immunosuppressive monocytemacrophage subset. Additionally, the encapsulation of CCL2 within the nanocapsules induced a potent monocyte-macrophage chemoattraction that could be used to direct the therapy to these cell subsets. Finally, in vitro and in vivo studies showed the capacity of shC/EBPβ-loaded nanocapsules to downregulate C/EBPβ levels in MDSCs and to reduce monocyte differentiation into tumor-associated macrophages in an MCA-203 fibrosarcoma mice model. In conclusion, the multilayer polymer nanocapsules described here are efficient vehicles for the co-delivery of proteins and RNA, and are potential candidates as nanomedicines for the modulation of MDSCs.

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“…Bulimia is a common form of eating disorder to reduce body weight characterized by overeating followed by induced vomiting [43]. According to Uhlen et al [44], psychosomatic disorders such as anorexia and bulimia nervosa can result in typical dental erosion lesions.…”

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confidence: 99%

Effects of Bariatric Surgery on the Oral Health of Patients

Ic¹

2016

Int J dent Oral Health

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Objective: The objective of this prospective cross-sectional study was to analyze the effects of bariatric and metabolic surgery on the oral health of patients.Methods: Twenty-nine patients answered a questionnaire after undergoing bariatric surgery. Of these,18 accepted to have their dental condition clinically assessed as well. Mean postoperative time was 4 years. Oral and eating habits were assessed in order to detect the impact of gastroplasty on patients' lives and on their dental status. The Eccles index was usedto assess the level of dental erosion.Results: Bariatric surgery complications such as gastroesophageal reflux (55%), induced vomiting (90%), anxiety (65%), and systemic diseases such as anemia, high blood pressure, allergies or a combination of these (59%) were observed. Additionally, changes in eating habits such as craving for candies, ice, beer, finger foods, and sodas (59%), as well ashyposalivation (27%), parafunctional habits (55%), and dentin sensitivity (48%) were also reported. Among the patients submitted to the clinical examination, 55% demonstrated caries and 28% tooth wear Grade 1. Conclusion:Bariatric surgery had a negative effect on oral health, making the patient more susceptible to dental erosion. The integration of dentists into multidisciplinary teams is essential to early diagnosis and treatment of injuries caused by dental erosion. Dentists' awareness of the effects of bariatric surgery on the oral health can assist them to improve the quality of life of bariatric patients.

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Development of significant disordered eating in an adolescent following gastric bypass surgery

Cited by 5 publications

References 25 publications

Cirurgia bariátrica e transtornos alimentares: uma revisão integrativa

Cirurgia bariátrica e transtornos alimentares: uma revisão integrativa

Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells

Effects of Bariatric Surgery on the Oral Health of Patients

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