Increased contrast enhancing lesion activity in relapsing–remitting multiple sclerosis migraine patients

Graziano, Elliot; Hagemeier, Jesper; Weinstock‐Guttman, Bianca; Ramasamy, Deepa P.; Zivadinov, Robert

doi:10.1016/j.nicl.2015.07.013

Cited by 18 publications

(17 citation statements)

References 41 publications

(61 reference statements)

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“…Previous studies have suggested that migraines were linked to CIRDs [22,23]. We hypothesized that such a link might be explained by systemic inflammation, which might potentiate the neurogenic inflammation associated with migraines, as suggested in multiple sclerosis [10,24,25]. In the present study, systemic inflammation was never associated with migraine.…”

Section: Discussionsupporting

confidence: 46%

Prevalence of Migraine and Neuropathic Pain in Rheumatic Diseases

Mathieu

Couderc

Pereira³

et al. 2020

JCM

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To investigate the physiopathology of pain in chronic inflammatory rheumatic diseases (CIRDs), we assessed the prevalence of migraine and neuropathic pain in 499 patients with CIRDs. We studied 238 patients with rheumatoid arthritis, 188 with spondyloarthritis (SpA), 72 with psoriatic arthritis (PsA), and 1 unclassified. Migraine was diagnosed according to IHS migraine diagnostic criteria. Neuropathic pain was diagnosed when patients scored at least 3 on the DN4 questionnaire. Participants completed a validated self-assessment questionnaire. Migraine prevalence was 34% (165/484), and it was highest in PsA. Risk factors for migraine were a high level of anxiety, female sex, young age, and TNF-alpha inhibitor treatment (OR = 1.90 (1.13–3.25)). Besides, high disease activity was a risk factor in SpA. Blood CRP level was not significantly associated with migraine. Of 493 patients with CIRDs, 21.5% had chronic pain with neuropathic characteristics. Compared to the French general population, these patients had significantly higher prevalences of migraine (two-fold) and neuropathic pain (three-fold). This study showed that migraine and neuropathic pain frequently occurred in patients with rheumatic diseases. Therefore, upon reporting residual pain, these patients should be checked for the presence of migraine or neuropathic pain, despite adequate clinical control of rheumatic disease.

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Section: Discussionsupporting

confidence: 46%

Prevalence of Migraine and Neuropathic Pain in Rheumatic Diseases

Mathieu

Couderc

Pereira³

et al. 2020

JCM

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“…It has been considered the MRI hallmark for monitoring of MS. The inflammatory component of the disease is usually present in earlier stages of MS lesions [10] .…”

Section: Discussionmentioning

confidence: 99%

Determination of Activity of Multiple Sclerosis (MS) Lesions in the Brain by Different Magnetic Resonance Imaging (MRI) Pulse Sequences

Yousef¹,

Abuel-Wafa

2018

The Medical Journal of Cairo University

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Background: Multiple sclerosis is one of the commonest causes of chronic neurological disability in young and middle aged people. MRI offers a unique in-vivo investigative tool for its evaluation. Aim of Study: To reveal the value of different MRI pulse sequences in evaluation of multiple sclerosis affection of the brain. Patients and Methods: This is a prospective hospital analytic study enrolling 25 patients diagnosed to have definite multiple sclerosis according to the McDonald's Criteria for diagnosing multiple sclerosis during the period from April 2016 to February 2017. The study was conducted in the MRI Unit of the Radiology Department of Assiut University Hospital. Results: All the enhancing lesions showed restricted diffusion in DW images at high b values accounting for 100% sensitivity and negative predictive value of DWI pulse sequence. On the other hand, some of the non-enhancing MS lesions, showed diffusion restriction in DW images, assuming a positive predictive value and specificity of 36.3% and 94% respectively. Post-contrast Magnetization Transfer Contrast (MTC) images could significantly detect higher number of enhancing MS lesions than standard T1W-SE images. All the enhancing lesions depicted on post-contrast T 1 W-SE sequence were also seen enhancing in MTC images, but more conspicuous. Conclusion: Diffusion weighted imaging and magnetization transfer imaging provide suitable investigative tools for determination of multiple sclerosis activity.

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“…MS patients may experience both pain and spasticity, and pain secondary to spasticity or painful tonic spasms is a subtype of nociceptive pain frequently reported in MS (Solaro et al, 2018). Among primary headaches, migraine was reported to be three times more frequent in MS patients than in the general population, to carry a considerable disability, and to be associated with a more symptomatic course and an increased contrast enhancing lesion activity compared to MS patients without headache (Kister et al, 2010;Graziano et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Non-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: A Systematic Review

et al. 2020

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Background: Neuropathic and nociceptive pain frequently affect patients with multiple sclerosis (MS), with a prevalence close to 90% and significant impact on general health and quality of life. Pharmacological strategies are widely used to treat pain in MS, but their effectiveness and side-effects are controversial. Among non-pharmacological treatments for pain, non-invasive brain and spinal stimulation (NIBSS) has shown promising preliminary results in MS.Objective: Systematic review to investigate the effect of NIBSS for the management of pain in MS.Methods: A literature search using Pubmed, Science Direct and Web of Science was conducted from databases inception to February 21, 2020 for studies assessing the analgesic effect of NIBSS on pain in MS.Results: A total of 279 records were title- and abstract-screened, nine were assessed for full text and included. The NIBSS techniques explored were transcranial direct current stimulation (N = 5), transcranial magnetic stimulation (N = 2), transcranial random noise stimulation (N =1), transcutaneous spinal direct current stimulation (N = 1). The targets were the primary motor cortex (M1; N = 4), the left dorsolateral pre-frontal cortex (DLPFC; N = 3), the spinal cord (N = 1), unspecified brain target (N = 1). The study designs were randomized (N = 7), open label (N = 1), single case report (N = 1). Despite the differences in study design, target and NIBSS technique that impeded a meta-analysis, all the studies converge in showing a significant improvement of pain after active NIBSS with less consistent effects on other symptoms of the pain-related cluster (depression, fatigue, cognition) and quality of life.Conclusions: Excitatory NIBSS over M1, left DLPFC and spinal cord appear to be the most effective protocols for pain in MS. Open questions include the use of neurophysiological or neuroimaging surrogate outcome measures, the stratification of patients according to the clinical profiles and underlying pathogenetic mechanisms and the combination of NIBSS to pharmacological treatment, neurorehabilitation, or psychotherapy to improve the clinical effect. The duration of the effect to NIBSS and the feasibility and efficacy of telemedicine NIBSS protocols are other open key questions.

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Increased contrast enhancing lesion activity in relapsing–remitting multiple sclerosis migraine patients

Cited by 18 publications

References 41 publications

Prevalence of Migraine and Neuropathic Pain in Rheumatic Diseases

Prevalence of Migraine and Neuropathic Pain in Rheumatic Diseases

Determination of Activity of Multiple Sclerosis (MS) Lesions in the Brain by Different Magnetic Resonance Imaging (MRI) Pulse Sequences

Non-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: A Systematic Review

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