Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields

Golovin, Yuri I.; Gribanovsky, Sergey L.; Golovin, D. Yu.; Klyachko, Natalia L.; Majouga, Alexander G.; Master, Аlyssa M.; Sokolsky-Papkov, Marina; Kabanov, Alexander V.

doi:10.1016/j.jconrel.2015.09.038

Cited by 189 publications

(166 citation statements)

References 144 publications

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“…Magnetic iron oxide nanoparticles are very promising candidates for the applications in future nanomedicine, 1,2 in terms of developing smart therapy approaches. 3 Superparamagnetic iron oxide nanoparticles (SPIONs) could be used in a combined manner, ie, not only as contrast agents for diagnostics and treatment monitoring but also as active substances for medical treatment.…”

Section: Introductionmentioning

confidence: 99%

Low toxic maghemite nanoparticles for theranostic applications

Kuchma¹,

Zolotukhin²,

Belanova³

et al. 2017

IJN

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Background Iron oxide nanoparticles have numerous and versatile biological properties, ranging from direct and immediate biochemical effects to prolonged influences on tissues. Most applications have strict requirements with respect to the chemical and physical properties of such agents. Therefore, developing rational design methods of synthesis of iron oxide nanoparticles remains of vital importance in nanobiomedicine. Methods Low toxic superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications in oncology having spherical shape and maghemite structure were produced using the fast microwave synthesis technique and were fully characterized by several complementary methods (transmission electron microscopy [TEM], X-ray diffraction [XRD], dynamic light scattering [DLS], X-ray photoelectron spectroscopy [XPS], X-ray absorption near edge structure [XANES], Mossbauer spectroscopy, and HeLa cells toxicity testing). Results TEM showed that the majority of the obtained nanoparticles were almost spherical and did not exceed 20 nm in diameter. The averaged DLS hydrodynamic size was found to be ~33 nm, while that of nanocrystallites estimated by XRD waŝ16 nm. Both XRD and XPS studies evidenced the maghemite (γ-Fe 2 O 3 ) atomic and electronic structure of the synthesized nanoparticles. The XANES data analysis demonstrated the structure of the nanoparticles being similar to that of macroscopic maghemite. The Mossbauer spectroscopy revealed the γ-Fe 2 O 3 phase of the nanoparticles and vibration magnetometry study showed that reactive oxygen species in HeLa cells are generated both in the cytoplasm and the nucleus. Conclusion Quasispherical Fe 3+ SPIONs having the maghemite structure with the average size of 16 nm obtained by using the fast microwave synthesis technique are expected to be of great value for theranostic applications in oncology and multimodal anticancer therapy.

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Section: Introductionmentioning

confidence: 99%

Low toxic maghemite nanoparticles for theranostic applications

Kuchma¹,

Zolotukhin²,

Belanova³

et al. 2017

IJN

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“…In the case of shell carriers, one relies on softening/destruction of the membrane upon MNP oscillations in the AC MF and, as a consequence, an increase in the permeability of the shell or its total destruction. The corresponding magnetomechanical models were described in [10,11]. For MNP-based carriers covered with a shell of long and chaotically positioned polymer molecules, the possibility of a situation in which DMMs preliminarily loaded into this structure are washed out in the process of MNP oscillation in the AC MF was considered [9].…”

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confidence: 99%

Model of controlled drug release from functionalized magnetic nanoparticles by a nonheating alternating-current magnetic field

et al. 2016

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A magnetohydrodynamic model of controlled drug macromolecule release from transport magnetic nanoparticles covered by a polymer shell under the influence of a low-frequency (<1 kHz) nonheating magnetic field is described.Controlled release (CR) of drugs and genes from transport nanosize modules is a key element for the conception of addressed drug delivery [1]. There are several approaches to CR: changing the pH of the medium, light and ultrasonic stimulation, magnetic hyperthermia (MH) in the radio frequency (0.2-0.8 MHz) magnetic field, and others [1,2]. They all have some or other disadvantages (in particular, insufficient locality and selectivity, and side effects, among other things, are typical for most of them), which restricts the potential of their application.In a series of papers aimed at development of the MH technique [3][4][5][6], it was established that the biochemical response of a system is caused not only by the heat release in magnetic nanoparticles (MNPs), but also by some other nonthermal factors; the authors treated them as "mechanical," "vibrational," and "ultrasonic," without specifying the mechanisms. In works of several groups [7][8][9], with the aim to reduce the MNP heating in an alternating-current magnetic field (AC MF) to a negligibly small level and to amplify "mechanical" factors, frequency f of the AC MF was consciously chosen to be four or five orders of magnitude lower than for MH. Since the heating in the first approximation is proportional to f, it can be certainly neglected at f < 1 kHz. For carriers of drug macromolecules (DMMs), different objects are used: nanomicrocapsules, dendrimers, MNPs, and others. In the case of shell carriers, one relies on softening/destruction of the membrane upon MNP oscillations in the AC MF and, as a consequence, an increase in the permeability of the shell or its total destruction. The corresponding magnetomechanical models were described in [10,11]. For MNP-based carriers covered with a shell of long and chaotically positioned polymer molecules, the possibility of a situation in which DMMs preliminarily loaded into this structure are washed out in the process of MNP oscillation in the AC MF was considered [9]. However, a comprehensive theory or quantitative models for such processes have yet to be developed.In this work, a physical model of possible processes of the controlled DMM release from MNP-based carriers covered with a polymer shell by use of a homogeneous low-frequency (nonheating) AC MF is discussed. Understanding the CR mechanisms makes it possible to formulate requirements for the composition and design of MNP-based complexes and optimize AC MF parameters. The carrier may be a coreshell nanostructure containing a magnetic core (MNP itself) covered by a gold shell to which necessary polymer ligands can be easily attached by a covalent bond (Fig. 1). Molecules of the active substance (drugs, ferments, inhibitors, DNA, etc.) can be positioned between polymer chains and attached to them via different interactions and bonds. The value...

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“…磁性粒子サスペンションは非常に可能性のある機能性流体であり，その基礎および応用研究は，流体工学，磁気材料工学，医用工学，環境資源工学など，種々の分野で活発に研究が成されるに至っている．流体工学の分野では，印加磁場によって見かけ粘度が変化する磁気粘性効果を利用したダンパーやアクチュエータへの応用が主として考えられている (Rosensweig, 1987, Bullough, 1996, Wereley, 2013 Aggregation phenomena of a magnetic particle suspension in an alternating magnetic field and the influence on the heat generation effect (Brownian dynamics simulations) (Schmidt, 2007, Kumar and Mohammad, 2011, Obaidat et al, 2015, Golovin et al, 2015 などへの応用を目指した研究が非常に精力的に成されている．環境資源工学の分野では，海水などに溶けた貴金属を収集する技術や有害物質を回収する技術を構築するに際して，機能性磁性粒子を利用しようとする応用展開が活発に試みられている (Bruce andSen, 2005, Girginova et al, 2010 (Schmidt, 2007, Kumar and Mohammad, 2011, Obaidat et al, 2015, Golovin et al, 2015．振動磁場中での磁性粒子の磁気モーメントの磁場方向への緩和現象による発熱効果に関する理論は，先駆的な研究によりすでに構築されている (Rosensweig, 2002)．磁性サ…”

Section: 緒言unclassified

Aggregation phenomena of a magnetic particle suspension in an alternating magnetic field and the influence on the heat generation effect (Brownian dynamics simulations)

Suzuki

Satoh

Futamura

2018

Transactions of the JSME (In Japanese)

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We have elucidated the aggregation phenomena in a suspension composed of spherical magnetic particles in an alternating magnetic field by means of Brownian dynamics method. The relationship between aggregate structures and heating phenomena has been discussed using the hysteresis loops of the magnetic field-magnetization curves, which were obtained from Brownian dynamics simulations. A large heating effect is inevitably necessary in applying a magnetic particle suspension to magnetic hyperthermia treatment in the medical engineering field. We here focus on the Brownian relaxation mode of magnetic moments of particles as the factor inducing the heating effect. The main results obtained here are summarized as follows. In the situation where stable chain-like clusters are formed in the field direction, the magnetic particle-particle interaction induces a significant delay for the magnetic moments inclining in the alternating magnetic field direction. These chain-like clusters respond to a change in the magnetic field without collapse and reformation of the clusters, by the magnetic moment of each constituent particle rotating to incline in the field direction. These behaviors of chain-like clusters in an alternating magnetic field exhibit a hysteresis loop with large area in the magnetic filed-magnetization curve, which gives rise to a significantly large heating effect. On the other hand, in the situation where large clusters are formed but these clusters do not strongly tend to incline in the field direction, the area of the hysteresis loop becomes small and therefore a large heating effect cannot be obtained.

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Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields

Cited by 189 publications

References 144 publications

Low toxic maghemite nanoparticles for theranostic applications

Low toxic maghemite nanoparticles for theranostic applications

Model of controlled drug release from functionalized magnetic nanoparticles by a nonheating alternating-current magnetic field

Aggregation phenomena of a magnetic particle suspension in an alternating magnetic field and the influence on the heat generation effect (Brownian dynamics simulations)

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