Acquisition of a somatic nonsense mutation in the cells of the haematopoietic system might revert the cellular growth repression caused by the germline mutations (ie, second-site reversion mutations). Unexpected lack of haematological features in the two patients would be explained by the reversion mutations.
Rituximab efficiently reduces anti-ABO antibody titer by selectively eliminating B cells and is safe and effective against humoral rejection after ABO-incompatible liver transplantation.
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