The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

Abstract

BackgroundAbdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population.MethodsA total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in OS (pro-oxidant and antioxidant) were analyzed using the SNPlex system. The effects of the c.-793T > C polymorphism on promoter activity and thus thioredoxin (TXN) activity were examined using reporter assays.ResultsThe AO group had higher 8-Oxo-2′-deoxyguanosine levels and took in less vitamin A and vitamin E compared to the non-AO group. Logistic regression analysis revealed that the rs2301241 polymorphism in TXN and rs740603 in catechol-O-methyltransferase (COMT) were associated with waist circumference (WC) and AO. Moreover, these polymorphisms were more strongly associated with variations in WC in subjects with low vitamin E intakes. A promoter assay revealed that the T to C conversion at c.-793 (rs2301241) induced a more than two fold increase in reporter gene expression.ConclusionsWC is associated both with dietary vitamin E intake and genetic variants of TXN and COMT suggesting that existence of a complex nutrigenetic pathway that involves regulation of AO.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-015-0652-4) contains supplementary material, which is available to authorized users.

Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study

“…The study shows a negative correlation between Vitamin E and waist circumference, similar to other studies [ 28 ]. The relationship between this vitamin and increased adiposity has been investigated in the literature because of its functions in reducing adipose tissue fibrosis, inflammation, and oxidative stress due to its anti-inflammatory and antioxidant capacity.…”

“…The significant negative correlation between retinol and glucose observed in our study is similar to the findings of Teske and co-workers (2014) [ 26 ] in a study conducted with children and adolescents with obesity. Hyperglycemia is one of the conditions of obesity that contributes to oxidative stress, favoring the formation of reactive oxygen species, which increases the expense of micronutrients with antioxidant function [ 28 ]. In addition, since it is a condition related to type 2 diabetes mellitus, and to insulin resistance, there is evidence that retinol can increase insulin sensitivity by promoting its increased signaling [ 29 ].…”

Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective

“…COMT (ENSP00000354511) has also been predicted to be a co-related gene for both obesity and psychiatric diseases. A case study [ 93 ] in 2015 validated that the polymorphisms of COMT may be correlated with obesity occurrence. Further study on COMT confirmed that such gene turns out to be one of the potential pathogenic gene for Parkinson disease, validating the efficacy and accuracy of our prediction.…”

Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial

“…Dietary factors may influence gene expression [ 11 12 13 ]. One case control study [ 11 ] reported a nutrigenetic interaction between dietary vitamin E and thioredoxin and catechol-Omethyltransferase gene polymorphisms on waist circumference. Dietary factors may also alter the risk of inflammatory disease.…”