Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis

Ye, Huadan; Zhou, Ang; Hong, Qiangxiao; Tang, Linlin; Xu, Xuting; Xin, Yanfei; Jiang, Danjie; Dai, Dongjun; Li, Yirun; Wang, Dao Wen; Duan, Shiwei

doi:10.1371/journal.pone.0135683

Cited by 22 publications

(24 citation statements)

References 65 publications

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“…In the literature, some studies demonstrated that this polymorphism is associated with higher levels of TG [ 12 – 25 ], total cholesterol (TC) [ 17 ] and LDL-C [ 18 ], and lower levels of HDL-C [ 14 – 22 ]. A significant association between this variant and the presence of CHD was also reported in several studies [ 22 – 24 , 26 , 27 ]. However, whether this polymorphism is associated with the severity of CHD has not been reported before.…”

Section: Introductionsupporting

confidence: 73%

The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Wang

Zhang

et al. 2016

Lipids Health Dis

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BackgroundThe APOA5 rs662799 polymorphism has been widely reported regarding its associations with the plasma lipid levels and the occurrence of coronary heart disease (CHD), whereas its relationship with the severity of CHD has not yet been explored.MethodsFour hundred and seventy-eight angiografically defined subjects (325 CHD patients and 153 CHD-free controls) were enrolled in this study. The rs662799 polymorphism was genotyped, and the fasting lipid data were collected for all participants. The severity of CHD was evaluated for the CHD patients by using Gensini scores.ResultsThe variant C allele of the rs662799 polymorphism was associated with lower levels of HDL-C in CHD-free women, and higher levels of TG and TG/HDL-C in women with CHD (P < 0.05 for all). The C allele was associated with higher prevalence of dyslipidemia and higher levels of Gensini scores only in women (P < 0.05 for both), but not in men. Multivariate linear regression analysis showed that the rs662799 polymorphism was independently associated with the Gensini scores in women after adjustment for other potential CHD risk factors (Beta = 0.157, 95 % CI: 0.017–0.298, P = 0.028).ConclusionOur data indicate that the rs662799 polymorphism is associated with dyslipidemia and the severity of CHD in Chinese women.

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Section: Introductionsupporting

confidence: 73%

The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Wang

Zhang

et al. 2016

Lipids Health Dis

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“…A number of SNPs of APOA5 associated with TG and HDL-C levels have been reported [9]. Among these SNPs, rs662799, which is located in the promotor region of the APOA5 gene, was associated with TG levels and coronary heart disease in a Japanese and a Chinese population [10,11]. Association between rs662799 and elevated TG level was validated in Koreans [12,13].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study of metabolic syndrome in Korean populations

Lee

Shin

et al. 2020

PLoS ONE

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Metabolic syndrome (MetS) which is caused by obesity and insulin resistance, is well known for its predictive capability for the risk of type 2 diabetes mellitus and cardiovascular disease. The development of MetS is associated with multiple genetic factors, environmental factors and lifestyle. We performed a genome-wide association study to identify single-nucleotide polymorphism (SNP) related to MetS in large Korean population based samples of 1,362 subjects with MetS and 6,061 controls using the Axiom ® Korean Biobank Array 1.0. We replicated the data in another sample including 502 subjects with MetS and 1,751 controls. After adjusting for age and sex, rs662799 located in the APOA5 gene were significantly associated with MetS. 15 SNPs in GCKR, C2orf16, APOA5, ZPR1, and BUD13 were associated with high triglyceride (TG). 14 SNPs in APOA5, ALDH1A2, LIPC, HERPUD1, and CETP, and 2 SNPs in MTNR1B were associated with low high density lipoprotein cholesterol (HDL-C) and high fasting blood glucose respectively. Among these SNPs,

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“…Its polymorphism has been found to be involved in the development of diabetic microangiopathy. 21,40 Sex differences in the HIF1A polymorphism have also been demonstrated by Gu et al, 40 who studied patients with diabetic nephropathy. These authors showed that a particular genetic variant of HIF1A decreases the risk of diabetic nephropathy in men, but not in women.…”

Section: Supplementary Materialsmentioning

confidence: 55%

The impact of polymorphism of selected genes on the diagnosis of type 2 diabetes in patients with obstructive sleep apnea

Bielicki

Pierpoint²,

Brzóska

et al. 2018

Polish Archives of Internal Medicine

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INTRODUCTION Although the coexistence of type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) may be attributed to environmental risk factors common for both diseases, a genetic background should also be considered. Data on the role of genetic factors in the development of T2DM in patients with OSA are lacking. OBJECTIVES The study was aimed to evaluate the prevalence of polymorphisms of selected genes that are known to be associated with diabetes or obesity in patients with OSA and concomitant T2DM and to assess these polymorphisms in the context of OSA severity. PATIENTS AND METHODS Consecutive patients with newly diagnosed OSA confirmed by polysomnography underwent genotyping for the following single nucleotide polymorphisms (SNPs): SREBF1 rs11868035, HIF1A rs11549465, APOA5 rs3135506, TCF7L2 rs7903146, and FTO rs16945088. The frequency of genotypes was compared between patients with and without concomitant T2DM and was analyzed with regard to OSA severity. RESULTS A total of 600 patients with newly diagnosed OSA were enrolled to the study. Of these, 121 patients (20.2%) were diagnosed with T2DM (97 men and 24 women; median age, 58 years; range, 52-64 years). The prevalence of T2DM was significantly lower in APOA5 rs3135506 GG homozygotes than in CG heterozygotes (18.8% vs 33.3%, P = 0.02). APOA5 rs3135506 CG heterozygotes were at higher risk for developing T2DM (adjusted odds ratio, 2.64; 95% confidence interval,1.38-5.04; P = 0.003). No significant differences were found for the genotype distribution of the other investigated SNPs. CONCLUSIONS Our study shows a possible link between the polymorphism of the gene encoding APOA5 and T2DM in patients with OSA.

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Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis

Cited by 22 publications

References 65 publications

The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Genome-wide association study of metabolic syndrome in Korean populations

The impact of polymorphism of selected genes on the diagnosis of type 2 diabetes in patients with obstructive sleep apnea

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