The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Wang, Yanmei; Li, Zhan; Zhang, Jingxiao; Yang, Yang; Shen, Jing; Zhang, Xiaoming; Song, Yongyan

doi:10.1186/s12944-016-0343-z

Cited by 24 publications

(21 citation statements)

References 33 publications

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“…ApoA5 also inhibits production of very low-density lipoprotein (VLDL) TG [ 5 6 7 ] and stimulates hydrolysis of VLDL TG mediated by lipoprotein lipase (LPL) [ 6 7 ], thereby reducing circulating TG levels [ 5 8 ]. Consequently, single-nucleotide polymorphisms (SNPs) in APOA5 have been shown to be involved in TG metabolism in both fasting and postprandial states and are considered as important contributors to the development of obesity, dyslipidemia, CVD, diabetes, and vascular complications in type 2 diabetes [ 9 10 11 12 13 ]. Among commonly studied APOA5 SNPs, -1131T > C (rs662799) and 56C > G (rs3135506) are considered to be functional-tag SNPs at APOA5 [ 12 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among commonly studied APOA5 SNPs, -1131T > C (rs662799) and 56C > G (rs3135506) are considered to be functional-tag SNPs at APOA5 [ 12 13 ]. It has been previously reported that the frequency of the APOA5 -1131C allele is higher in East Asians (> 25%) than in Westerners (9–16%) [ 9 10 11 12 13 ]. The minor C allele of APOA5 rs662799 is associated with a higher circulating TG level and independently contributes to increased risk of CVD [ 11 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been previously reported that the frequency of the APOA5 -1131C allele is higher in East Asians (> 25%) than in Westerners (9–16%) [ 9 10 11 12 13 ]. The minor C allele of APOA5 rs662799 is associated with a higher circulating TG level and independently contributes to increased risk of CVD [ 11 13 ]. On the other hand, the minor G allele of APOA5 rs3135506, which is associated with risk of myocardial infarction and metabolic syndrome (MetS), was reported to be more common in Westerners (6–15%) than in Asians (0.1–3%) [ 12 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein A53'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey

Kim

Moon

et al. 2018

Nutr Res Pract

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BACKGROUND/OBJECTIVESThis study aimed to test the association between APOA5 3'-UTR variants (rs662799) and cardiometabolic traits in Koreans.SUBJECTS/METHODSFor this study, epidemiological data, Apolipoprotein A5 (APOA5) genotype information, and lymphoblastoid cell line (LCL) biospecimens from a subset of the Ansung-Ansan cohort within the Korean Genome and Epidemiology study (KoGES-ASAS; n = 7,704) as well as epidemiological data along with genomic DNA biospecimens of participants from a subset of the Korea National Health and Nutrition Examination Survey (KNHANES 2011-12; n = 2,235) were obtained. APOA5 mRNA expression was also measured.RESULTSAPOA5 rs662799 genotype distributions in both the KoGES-ASAS and KNHANES groups were 50.6% for TT, 41.3% for TC, and 8.1% for CC, which are similar to those in previous reports. In both groups, minor C allele carriers, particularly subjects with CC homozygosity, had lower high-density lipoprotein (HDL) cholesterol and higher triglyceride levels than TT homozygotes. Linear regression analysis showed that the minor C allele significantly contributed to reduction of circulating HDL cholesterol levels [β = −2.048, P < 0.001; β = −2.199, P < 0.001] as well as elevation of circulating triglyceride levels [β = 0.053, P < 0.001; β = 0.066, P < 0.001] in both the KoGES-ASAS and KNHANES groups. In addition, higher expression levels of APOA5 in LCLs of 64 healthy individuals were negatively associated with body mass index (r = −0.277, P = 0.027) and circulating triglyceride level (r = −0.340, P = 0.006) but not significantly correlated with circulating HDL cholesterol level. On the other hand, we observed no significant difference in the mRNA level of APOA5 according to APOA5 rs662799 polymorphisms.CONCLUSIONSThe C allele of APOA5 rs662799 was found to be significantly associated with cardiometabolic traits in a large Korean population from the KoGES-ASAS and KNHANES. The effect of this genotype may be associated with post-transcriptional regulation, which deserves further experimental confirmation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein A53'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey

Kim

Moon

et al. 2018

Nutr Res Pract

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“…Apolipoprotein A5 is the protein that is encoded by the APOA5 gene. It plays an important role in regulating the level of triglycerides in blood plasma [27]. The gene polymorphisms are associated with a change in the triglyceride level.…”

Section: Genes Responsible For the Digestion And Absorption Of Carbohmentioning

confidence: 99%

Genes and Eating Preferences, Their Roles in Personalized Nutrition

Vesnina

Prosekov

Kozlova

et al. 2020

Genes

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At present, personalized diets, which take into account consumer genetic characteristics, are growing popular. Nutrigenetics studies the effect of gene variations on metabolism and nutrigenomics, which branches off further and investigates how nutrients and food compounds affect genes. This work deals with the mutations affecting the assimilation of metabolites, contributing to nutrigenetic studies. We searched for the genes responsible for eating preferences which allow for the tailoring of personalized diets. Presently, genetic nutrition is growing in demand, as it contributes to the prevention and/or rehabilitation of non-communicable diseases, both monogenic and polygenic. In this work, we showed single-nucleotide polymorphisms in genes—missense mutations that change the functions of coded proteins, resulting in a particular eating preferences or a disease. We studied the genes influencing food preferences—particularly those responsible for fats and carbohydrates absorption, food intolerance, metabolism of vitamins, taste sensations, oxidation of xenobiotics, eating preferences and food addiction. As a result, 34 genes were identified that affect eating preferences. Significant shortcomings were found in the methods/programs for developing personalized diets that are used today, and the weaknesses were revealed in the development of nutrigenetics (inconsistency of data on SNP genes, ignoring population genetics data, difficult information to understand consumer, etc.). Taking into account all the shortcomings, an approximate model was proposed in the review for selecting an appropriate personalized diet. In the future, it is planned to develop the proposed model for the compilation of individual diets.

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“…[11][12][13][14][15] Over the years, several common single nucleotide polymorphisms (SNPs) with significant effects on plasma TG levels have been identified, including genetic variants in lipoprotein lipase (LPL) and apolipoprotein A-V (APOA5). [16][17][18] Subsequently, genome-wide association studies (GWAS) were able to replicate these findings and identify additional loci, such as those encoding for tribbles pseudokinase 1(TRIB1), glucokinase regulator (GCKR), and angiopoietin-like protein 4 (ANGPTL4), thereby stressing the polygenic nature of plasma TG levels. 4,[19][20][21][22][23][24][25][26][27][28] It has been shown that loss of function variants in APOC3 results in decreased risk for CHD as shown in 2 large population cohorts.…”

Section: Introductionmentioning

confidence: 99%

A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk

Verbeek

Oldoni

Surendran

et al. 2019

Journal of Clinical Lipidology

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BACKGROUND: Evidence on the causal link between plasma triglyceride (TG) levels and risk for cardiovascular disease (CVD) has recently emerged. Individuals with the metabolic syndrome have an increased risk for acquiring elevated TG levels later in life. Moreover, common DNA sequence variations in genes affecting TG levels identify individuals at risk for elevated plasma TG levels.OBJECTIVE: We evaluated whether a 3-single nucleotide polymorphism (SNP) TG gene risk score (GRS) and a metabolic risk score (MetRS) both improved CVD risk prediction.METHODS: A 3-SNP GRS and MetRS were generated in the EPIC-Norfolk cohort (n 5 20,074) based on 3 SNPs in LPL and APOA5 or the number of Metabolic Syndrome criteria present (maximum 5), respectively. The associations between the 3-SNP GRS, MetRS, TG levels, and CVD risk were evaluated.RESULTS: The 3-SNP GRS and MetRS were both linearly associated with plasma TG levels, that is, 10.25 mmol/L [95% CI 0.22-0.27] per allele change (P , .001) and 10.72 mmol/L [95% CI 0.70-0.73] per increase of number of metabolic syndrome risk score points (P , .001), respectively. We observed a positive association between the 3-SNP GRS and the risk of CVD with an adjusted hazard ratio (HR) of 1.35 [95% CI 1.04-1.74] for the highest versus the lowest GRS, which was independent of the MetRS. For the MetRS, the adjusted HR was 2.03 [95% CI 1.73-2.40] for the highest versus the lowest MetRS.

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The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Cited by 24 publications

References 33 publications

Apolipoprotein A53'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey

Apolipoprotein A53'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey

Genes and Eating Preferences, Their Roles in Personalized Nutrition

A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk

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