A prospective randomized clinical trial into the capacity of a toothpaste containing NovaMin to prevent white spot lesions and gingivitis during orthodontic treatment

Abstract

BackgroundWhite spot lesions and gingivitis represent common, yet challenging, dilemmas for orthodontists. Fluoride has shown some benefit as a protective measure against demineralization; however, this is usually insufficient for orthodontic patients with less than ideal oral hygiene. Dentifrices containing calcium sodium phosphosilicate bioactive glass (NovaMin) have been proposed to aid in prevention of white spot lesions and gingival inflammation. Thus, the purpose of this study was to determine if the use of NovaMin reduces the formation of white spot lesions and improves gingival health in orthodontic patients.MethodsThis was a prospective, double-blind, randomized controlled trial. Forty-eight patients undergoing orthodontic treatment were randomly allocated to two groups. The control group consisted of 24 patients who received over-the-counter fluoride toothpaste (Crest®), while the study group consisted of 24 patients who were given the test dentifrice (ReNew™) containing 5 % NovaMin and fluoride. Patients were followed up for 6 months on a monthly basis. Decalcification, gingival health, plaque, and bacteria levels were evaluated every 3 months. Statistical analysis was performed using both parametric and non-parametric tests to identify differences between groups at different time points.ResultsThere were no significant differences between the groups in regard to changes in white spot lesions, plaque, or gingival health (P > 0.05). There was a trend toward improvement in white spot lesions found in subjects using Crest® at the 3-month time point; however, this was not sustained throughout the study.ConclusionsOur results indicate that a toothpaste containing NovaMin does not differ significantly compared to traditional fluoride toothpaste for improving white spot lesions and gingivitis in orthodontic patients.

Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): a clinical trial

“…We observed that the use of 1000 ppm of fluoride toothpaste twice daily alone had beneficial effect on the regression of WSLs. Similar to our observation, Hoffman et al [ 29 ] also observed that the use of traditional fluoride toothpaste alone was effective in improving white spot lesions during orthodontic treatment. However, in contrast to our observation, many previous studies [ 13 , 16 ] reported that the toothpaste alone was not effective in reducing the post-orthodontic WSLs.…”

Biosynthesis of Silver Nanoparticles on Orthodontic Elastomeric Modules: Evaluation of Mechanical and Antibacterial Properties

“…Studies by O’Reilly et al and Øgaard et al showed development of clinically visible WSL in orthodontic patients that occurred in four weeks or less [ 6 , 7 ]. Gorelick et al studied the incidence of WSL in orthodontic patients and found that almost 50% of orthodontic patients developed at least one WSL during the course of treatment [ 8 , 9 , 10 ].…”

Effect of fluoride dentifrices on white spot lesions during orthodontic treatment: A randomized trial

“…A more serious limitation was the duration of this study, which was designed to be 4 months based on some previous studies. 9,19,20 It is found that development of clinically visible WSLs in orthodontic patients can occur within 4 weeks or less. 21,22 In addition, the prevalence of white spots in orthodontic treatment was reported to reach 38% in 6 months, and increased slightly to 46% after 12 months.…”