Genistein-induced mir-23b expression inhibits the growth of breast cancer cells

Avci, Çığır Biray; Süslüer, Sunde Yılmaz; Çağlar, Hasan Onur; Balci, Tugce B.; Aygüneş, Duygu; Dodurga, Yavuz; Gündüz, Cumhur

doi:10.5114/wo.2014.44121

Cited by 26 publications

(16 citation statements)

References 25 publications

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“…Analysis of miR‐23b by qPCR demonstrated that this miRNA is also downregulated. miR‐23b has been shown to be involved in a wide range of cellular processes and aberrant expression of miR‐23b has been reported in many types of cancers . Zhang et al showed that miR‐23b suppressed invasion and metastasis both in vitro and in vivo .…”

Section: Discussionmentioning

confidence: 99%

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Terron‐Canedo

Weir

Nicolson

et al. 2016

Vet Comparative Oncology

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Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological and cellular processes, have been found dysregulated in a wide range of tumours. The aim of this study was to identify miRNAs associated with ES. Differential expression of miRNAs was assessed in control equine fibroblasts (EqPalFs) and EqPalFs transformed with the BPV-1 genome (S6-2 cells). Using a commercially available miRNA microarray, 492 mature miRNAs were interrogated. In total, 206 mature miRNAs were differentially expressed in EqPalFs compared with S6-2 cells. Aberrant expression of these miRNAs in S6-2 cells can be attributed to the presence of BPV-1 genomes. Furthermore, we confirm the presence of 124 miRNAs previously computationally predicted in the horse. Our data supports the involvement of miRNAs in the pathogenesis of ES.2

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Section: Discussionmentioning

confidence: 99%

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Terron‐Canedo

Weir

Nicolson

et al. 2016

Vet Comparative Oncology

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“…Genistein also induced miR-146a expression associated with suppression of pancreatic cancer cell invasion via downregulation of miR-146a targets such as EGFR, MTA-2, IRAK-1, and NF-κB [141] . More recently, genistein exhibited distinct cell growth inhibition of breast cancer cells (MCF-7) by up-regulation of miR-23b expression (56.69-fold compared with untreated cells) [142] .…”

Section: Dietary Compounds and Natural Products (Phenols And Terpenoimentioning

confidence: 99%

Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

Biersack

2016

Non-coding RNA Research

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The epigenetic regulation of cancer cells by small non-coding RNA molecules, the microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs play crucial roles concerning pathogenic properties of cancer cells and the sensitivity of cancer cells towards anticancer drugs. Certain miRNAs are responsible for an enhanced activity of drugs, while others lead to the formation of tumor resistance. In addition, miRNAs regulate survival and proliferation of cancer cells, in particular of cancer stem-like cells (CSCs), that are especially drug-resistant and, thus, cause tumor relapse in many cases. Various small molecule compounds were discovered that target miRNAs that are known to modulate tumor aggressiveness and drug resistance. This review comprises the effects of naturally occurring small molecules (phenolic compounds and terpenoids) on miRNAs involved in cancer diseases.

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“…Notable are also its anti-tumor effects, demonstrated especially in breast cancer 20 , 36 – 38 and prostate cancer. 39 – 41 …”

Section: Discussionmentioning

confidence: 99%

In vitro study on anti-cancer properties of genistein in tongue cancer

Ardito¹,

Pellegrino²,

Perrone³

et al. 2017

OTT

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PurposeTongue cancer is an extremely aggressive disease and is characterized by a poor prognosis. It is a complex disease to treat and current therapies have produced mediocre results with many side effects. Some facts suggest that natural essences can support traditional cancer therapy by carrying out a synergistic function with chemotherapy. Therefore, we evaluated the antitumor effects of genistein on tongue carcinoma cells.MethodsGenistein 20, 50 and 100 µM were used for 24, 48 and 72 hours on 3 tongue carcinoma cell lines. xCELLigence system was used to evaluate the effects on cell adhesion, proliferation and to calculate IC50 values. Both MTT assay and Trypan blue assay were used to evaluate alterations in cell viability, scratch assay for cell migration and Western blot analysis for expression of some proteins.ResultsCell adhesion was inhibited especially between 20 and 50 µM of genistein treatment. Proliferation was reduced by 50% for treatments with 20 µM at 24 hours, with 20 or 50 µM at 48 and 50 µM at 72 hours (P<0.0001). Viability tests confirmed a proportional reduction in concentration of genistein and duration of treatments. Even cell migration was reduced significantly (P<0.001). Genistein down-regulates vitronectin, OCT4 and survivin.ConclusionThis in vitro study clarifies the anti-tumor effect of genistein on tongue carcinoma. In vivo studies are needed to confirm these data and develop a suitable delivery system that is capable of acting directly on tumor.

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Genistein-induced mir-23b expression inhibits the growth of breast cancer cells

Cited by 26 publications

References 25 publications

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

In vitro study on anti-cancer properties of genistein in tongue cancer

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