Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

Biersack, Bernhard

doi:10.1016/j.ncrna.2016.07.001

Cited by 41 publications

(27 citation statements)

References 373 publications

(427 reference statements)

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“…Recently, a class of non-coding RNAs, called microRNAs (miRNAs), has gained great attention as negative regulators of gene expression that impact proliferation, differentiation, and apoptosis of cells [ 121 ]. The regulatory effects of natural compounds on miRNAs are intensively studied especially in cancer prevention and therapy [ 122 , 123 ]. Curcumin modulates the expression of miRNAs in various cancer cells including pancreatic cancer [ 124 ], breast cancer [ 125 ], and lung cancer [ 126 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Cytoprotective Effects of Natural Compounds against Oxidative Stress

2018

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Oxidative stress, an imbalance between reactive oxygen species and antioxidants, has been witnessed in pathophysiological states of many disorders. Compounds identified from natural sources have long been recognized to ameliorate oxidative stress due to their inherent antioxidant activities. Here, we summarize the cytoprotective effects and mechanisms of natural or naturally derived synthetic compounds against oxidative stress. These compounds include: caffeic acid phenethyl ester (CAPE) found in honey bee propolis, curcumin from turmeric roots, resveratrol abundant in grape, and 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), a synthetic triterpenoid based on naturally occurring oleanolic acid. Cytoprotective effects of these compounds in diseases conditions like cardiovascular diseases and obesity to decrease oxidative stress are discussed.

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Section: Future Perspectivesmentioning

confidence: 99%

Cytoprotective Effects of Natural Compounds against Oxidative Stress

2018

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“…A single miRNA is able to target more than one hundred genes; additionally each gene contains multiple binding sides for miRNAs. 5 Thus, they are involved in many multiple signaling pathways including cancer regulation processes especially, cell proliferation, and migration, metastasis, apoptosis, and cell differentiation in numerous malignancies.…”

Section: Micrornas and Their Roles In Cancer-related Processesmentioning

confidence: 99%

“…[5][6][7][8] [13][14][15][16][17][18] The miRNAs regulated by a selection of important anticancer natural products and compounds that obtained from main known medicinal plants are presented in Table 1. As summarized in Table 1, recent studies and clinical trials which are aimed to find novel targets for the treatment of multiple types of cancers, have emphasized the importance of the consumption of natural agents-rich diet, including curcumin, berberine, alkaloids, mitomycin C, resveratrol, camptothecin, topotecan, trabectedin, matrine, honokiol, isoflovones, indole-3-carbinol, sulforaphane, water soluble vitamins, diallyl disulfide, 3,3'-diindolylmethane, epigallocatechin-3-gallate and hesperidin, etc., additionally syntheses of natural products by the liposome or nanoparticle formulations assays.…”

Section: Regulation Of Micrornas Expressions By Dietary Compounds Andmentioning

confidence: 99%

“…As summarized in Table 1, recent studies and clinical trials which are aimed to find novel targets for the treatment of multiple types of cancers, have emphasized the importance of the consumption of natural agents-rich diet, including curcumin, berberine, alkaloids, mitomycin C, resveratrol, camptothecin, topotecan, trabectedin, matrine, honokiol, isoflovones, indole-3-carbinol, sulforaphane, water soluble vitamins, diallyl disulfide, 3,3'-diindolylmethane, epigallocatechin-3-gallate and hesperidin, etc., additionally syntheses of natural products by the liposome or nanoparticle formulations assays. 5,7,[16][17][18] The bioactive compounds and natural products have significant influences on the epigenetic changes in the cancer cells. For instance, they regulate the expression levels of miRNAs by effecting the several proteins that are involved in the stages of tumorogenesis both cancer initiation and development.…”

Section: Regulation Of Micrornas Expressions By Dietary Compounds Andmentioning

confidence: 99%

“…In addition to, they have play critical roles in discovering efficient and clinically useful therapeutic anticancer agents. 5,6 However, medicinal plants contain many natural products and compounds against the cancer, berberine, curcumin, genistein, daidzein, glyceollin, apigenin, quercetin, baicalein, resveratrol, luteolin, matrine, garcinol, silibinin, mangiferin, doxorubicin, and paclitaxel are common natural products and compounds found to associate with cell differentiation, proliferation and apoptosis that exhibit anticancer activities on various human cancer types. [7][8][9] Plant derivatives natural products are capable of altering cellular signaling through epigenetic changes that include DNA methylation and histone modifications.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regulation of MicroRNAs by Natural Products and Bioactive Compounds Obtained From Common Medicinal Plants: Novel Strategy in Cancer Therapy

Gezici¹,

Şekeroğlu²

2017

IJPER

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MicroRNAs (miRNAs) are highly conserved non-protein coding small RNAs, known to contribute to the epigenetic regulation process in various cancer cells, including the regulation of progression, proliferation and metastasis of cancer cells, differentiation of the cells and process of apoptosis. In addition to, they are crucial for the regulation of cancer stem cells, and management the process of epithelial to mesenchymal transition of cancer cells, implicating in the cancer cells. Further to this, their roles are changeable depending on biological processes, for example miR-17, miR-20a, miR-19b-1, miR-18a, miR-19a, miR-92-1, miR-21, and miR-155 may have critical roles as oncogenic miRNAs (oncomiRs), while miR-15, miR-16, let-7, miR-34, miR-48, miR-84, miR-241 may have anticancer activities as tumor suppressor miRNAs. Therefore, the regulation of miRNAs levels by active natural compounds and/or products could be a promising strategy for cancer treatment, especially in order to inhibit cancer progression and proliferation, prevent metastasis, control the process of transition of cancer cells, and overcome chemotherapeutic resistance by increasing drug sensitivity as well. Recent studies and clinical trials which are aimed to find novel targets for the treatment of cancer, have emphasized the importance of the consumption of natural anticancer agents-rich diet. In the current review, we aimed to provide overview anticancer effects of natural compounds and/or products, isolated from medicinal plants, on miRNAs which are closely related to cancer progression and metastasis.

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miRNA, phytometabolites and disease: Connecting the dots

Ramprosand,

Govinden‐Soulange,

Ranghoo‐Sanmukhiya

et al. 2024

Phytotherapy Research

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AbstractmiRNAs are tiny noncoding ribonucleotides that function as critical regulators of gene‐expression in eukaryotes. A single miRNA may be involved in the regulation of several target mRNAs forming complex cellular networks to regulate diverse aspects of development in an organism. The deregulation of miRNAs has been associated with several human diseases. Therefore, miRNA‐based therapeutics is gaining interest in the pharmaceutical industry as the next‐generation drugs for the cure of many diseases. Medicinal plants have also been used for the treatment of several human diseases and their curative potential is attributed to their reserve in bioactive metabolites. A role for miRNAs as regulators of the phytometabolic pathways in plants has emerged in the recent past. Experimental studies have also indicated the potential of plant encoded secondary phytometabolites to act as cross‐regulators of mammalian miRNAs and transcripts to regulate human diseases (like cancer). The evidence for this cross‐kingdom gene regulation through miRNA has gathered considerable enthusiasm in the scientific field, even though there are on‐going debates regarding the reproducibility and the effectiveness of these findings. In this review, we provide information to connect the medicinal and gene regulatory properties of secondary phytometabolites, their regulation by miRNAs in plants and their effects on human miRNAs for regulating downstream metabolic or pathological processes. While further extensive research initiatives and good clinical evidence are required to prove or disapprove these findings, understanding of these regulations will have important implications in the potential use of synthetic or artificial miRNAs as effective alternatives for providing health benefits.

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Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention

Cited by 41 publications

References 373 publications

Cytoprotective Effects of Natural Compounds against Oxidative Stress

Cytoprotective Effects of Natural Compounds against Oxidative Stress

Regulation of MicroRNAs by Natural Products and Bioactive Compounds Obtained From Common Medicinal Plants: Novel Strategy in Cancer Therapy

miRNA, phytometabolites and disease: Connecting the dots

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