Underrecognition of Dengue during 2013 Epidemic in Luanda, Angola

Sharp, Tyler M.; Moreira, Rosa; Soares, M. A.; Costa, Lúis Miguel da; Mann, Jennifer; Delorey, Mark J.; Hunsperger, Elizabeth; Muñoz‐Jordán, Jorge L.; Colón, Candimar; Margolis, Harold S.; Caravalho, Adelaide de; Tomashek, Kay M.

doi:10.3201/eid2108.150368

Cited by 44 publications

(45 citation statements)

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“…Occurrence of high OD values in older individuals (those ≥18.1 years of age) in this study is an indication that they are more commonly affected (Tables 3). Studies in Latin America where several reports of increased number of adolescents with recent dengue infections have been made (Bhatt et al, 2013; Sharp et al, 2013; Teixeira et al, 2013; Villar et al, 2015) lends credence to the findings in our present study. A cross-sectional survey of febrile patients in Pemba Island, Zanzibar further supports our findings with a sero-prevalence of 15.4% in adults vs. 1.9% in patients under 15 years old (Vairo et al, 2012).…”

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confidence: 89%

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High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria

2016

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Section: 0 Discussionsupporting

confidence: 89%

“…Between 2011 and 2012 in Abidjan – Cote d'Ivoire, 0.4% patients had IgM antibody (L'Azou et al, 2015). During the 2013 dengue epidemic in Luanda, Angola Ministry of Health reported 811 positive dengue cases (Sharp et al, 2015). In 2014, 3.2% dengue IgM was reported in a study involving 218 children in Ghana (Stoler et al, 2015).…”

Section: 0 Introductionmentioning

confidence: 99%

High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria

2016

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“…Although dengue is endemic in Africa, molecular epidemiology of circulating DENV is not well documented [17,18]. The increasing number of dengue outbreaks and improved access to laboratory diagnostic tools have allowed for more effective recognition of outbreaks through genomic-based surveillance [17,19].…”

Section: Introductionmentioning

confidence: 99%

Co-circulation of Dengue Virus Serotypes 1 and 3 during the 2019 epidemic in Dar es Salaam, Tanzania

Mwanyika

Mboera

Rugarabamu

et al. 2019

Preprint

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22 23 *gaspary.mwanyika@sacids.org 24 25 26 27 PLOS Neglected Tropical Diseases 2 28 Abstract 29 Background 30 Dengue is an important mosquito-borne viral disease in tropical and sub-tropical 31 countries. In this study molecular characterization was carried out to determine 32 dengue viruses circulating among patients at health facilities during 2019 epidemic in 33 Dar es Salaam, Tanzania. 34 Methods 35 The study involved outpatients seeking care for febrile illness at four health facilities 36 in Kinondoni and Ilala Districts of Dar es Salaam City in Tanzania. A total of 45 sera 37 from the outpatients were confirmed dengue-positive for dengue virus (DENV) non-38 structural protein 1 (NS1) antigen and/or NS1-IgG/IgM antibodies using on-site rapid 39 test. The presence of the virus was detected by reverse-transcription polymerase 40 chain reaction (RT-PCR) method. Of the 45 sera, 20 samples were selected 41 randomly for identification of specific dengue virus serotypes using RT-PCR followed 42 by evaluation of resulting amplicons on agarose gel electrophoresis. 43 Findings and significance 44 Both Dengue virus serotypes 1 (DENV-1) and 3 (DENV-3) were detected in the 45 samples tested with the former being dominant. We present the first evidence of 46 dengue virus co-infection of DENV-1 and DENV-3 serotypes in Tanzania. The 47 emergence of DENV-1 indicates the possibility of importation of the virus to Tanzania 48 from endemic countries. Due to DENV serotype co-circulation, there is an increased 49 risk of severe dengue in future epidemics. Our findings advocate the importance of 50 genomic-based surveillance to provide rapid evidence of dengue virus 51 emergence/re-emergence and spread. 52 Author Summary 54 Dengue viruses are the most important mosquito-borne pathogens that pose a 55 serious global health threat. Tanzania has reported several dengue virus epidemics 56 since 2010 with the majority of the epidemics occurring in Dar-es-Salaam city. Until 57 August 2019, a total of 6,859 dengue cases have been confirmed in the country. We 58 performed molecular characterization of dengue viruses (DENV) circulating during 59 the 2019 epidemic phase. It was found that DENV-1 serotype was dominant during 60 the epidemic and two samples of the tested sera were co-infected by DENV-1 and 61

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“…Brazzaville in 2011 (19), and the 2013 DENV (20) and 2016 YFV outbreak in Angola (21) and 2012 when testing samples negative for YFV (28).…”

Section: Introductionmentioning

confidence: 99%

Dengue and Chikungunya among Febrile Outpatients in Kinshasa, Democratic Republic of Congo: a cross-sectional study

Proesmans

Katshongo

Milambu³

et al. 2018

Preprint

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Underrecognition of Dengue during 2013 Epidemic in Luanda, Angola

Abstract: Case detection should be improved by instituting routine laboratory-based surveillance for acute febrile illnesses in Africa. Dengue in Angola

Cited by 44 publications

References 34 publications

High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria

High rate of unrecognized dengue virus infection in parts of the rainforest region of Nigeria

Co-circulation of Dengue Virus Serotypes 1 and 3 during the 2019 epidemic in Dar es Salaam, Tanzania

Dengue and Chikungunya among Febrile Outpatients in Kinshasa, Democratic Republic of Congo: a cross-sectional study

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