Single-point fly cutting and nanoindentation test of quartz glass were performed using three different cutting tools, namely, a V-shaped cutting tool, a Vickers indenter and a spherical indenter, to investigate the elastic and plastic behaviors of quartz glass in ductile-regime machining. It was found that these behaviors depend on tool shape and that the V-shaped cutting tool is most effective for removing quartz glass material followed by the Vickers indenter and spherical indenter.