Altered pain modulation in patients with persistent postendodontic pain

Abstract

Patients suffering from persistent pain after endodontic treatment have less efficient pain modulation system compared with healthy controls.

Acute and chronic pain in orofacial trauma patients

“…80 Deficient pain modulation systems (inefficient inhibition or extensive augmentation) have been shown to be associated with various chronic pain conditions, including trigeminal neuropathies, 81 migraine, 82 burning mouth syndrome, 83 and TMD. In practice, a conditioning painful stimulus inhibits a test painful stimulus.…”

“…80 Deficient pain modulation systems (inefficient inhibition or extensive augmentation) have been shown to be associated with various chronic pain conditions, including trigeminal neuropathies, 81 migraine, 82 burning mouth syndrome, 83 and TMD. 81 This study could not answer the question of whether the chronic pain patients' CPM profile was determined by the chronic pain state or the patients are endowed with a less efficient CPM profile and consequently develop pain. 88 It was suggested that a pain modulation profile can be used as a tool for predicting the development of chronic pain and individualized pain management outcomes.…”

Chronic orofacial pain

“…Recent studies have demonstrated that reduced pain modulation is demonstrable in patients with PPTTN (Nasri‐Heir et al , ). The low incidence of CPSP in the trigeminal region may reflect the lack of central sensitisation due to most procedures being undertaken under local anaesthetic thus preventing central sensitisation (Woolf, ; Ossipov et al , ).…”

“…The low incidence of CPSP in the trigeminal region may reflect the lack of central sensitisation due to most procedures being undertaken under local anaesthetic thus preventing central sensitisation (Woolf, ; Ossipov et al , ). It is also recognised that post‐traumatic neuropathy is more resistant to medical management compared to other chronic pain conditions (Nasri‐Heir et al , ).…”

Orofacial neuropathic pain

“…Treatment follows the same orientations of those recommended for NP in general 47,48 . Recent studies have shown that samples of PIFP and PPTPN patients had no significant differences as compared to different sensitivity parameters 45 and also that patients with AO have descending inhibitory pain system impairment 49 .…”