Chronic orofacial pain

Renton, Tara

doi:10.1111/odi.12540

Cited by 23 publications

(18 citation statements)

References 27 publications

(59 reference statements)

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“…Animals subjected to IoN-CCI display behavioral phenotypes consistent with clinical symptoms caused by trigeminal nerve injury 21 . The improved dIoN-CCI surgical procedure is more suitable for studying trigeminal neuropathic pain.…”

Section: Discussionmentioning

confidence: 94%

An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve

Ding

You

Shen

et al. 2017

The Journal of Pain

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The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in the 1994, in which chronic constriction injury is induced by ligation of the infraorbital nerve (IoN-CCI). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligation of peripheral nerves (e.g. sciatic nerve). The aim of this study was to improve on the current surgical procedure of IoN ligation to induce trigeminal neuropathic pain in rats. We demonstrate that the IoN can be readily accessed through a small facial incision. Chronic constriction injury can be induced by ligation of a segment at the distal infraorbital nerve (dIoN-CCI). This dIoN-CCI procedure is simple, minimally invasive and time-saving. Our data show that the dIoN-CCI procedure consistently induced both acute and chronic nociceptive behaviors in rats. Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats. Perspective The orofacial pain caused by trigeminal nerve damage is severe and perhaps more debilitating than other types of neuropathic pain. However, studies on trigeminal neuropathic pain remain limited. This is largely due to the lack of proper animal models given the complexity of the existing surgical procedure required to induce trigeminal nerve injury. Our improved dIoN-CCI model is likely to make it more accessible to study the cellular and molecular mechanisms of neuropathic pain caused by trigeminal nerve damage.

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Section: Discussionmentioning

confidence: 94%

An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve

Ding

You

Shen

et al. 2017

The Journal of Pain

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“…Currently, dentists are facing increasing challenges from geriatric and special needs patients who suffer from psychiatric and neurological (particularly neurodegenerative) diseases . A greater effort is demanded for dental researchers to translate their research findings to clinical practice to achieve better diagnoses, treatments and outcome evaluations.…”

Section: Introductionmentioning

confidence: 99%

“…The focus was placed on MRI‐based neuroimaging methods, which have been the predominant methods of brain imaging used in dental research. It is noteworthy that this article did not aim to provide a full review of all the neuroimaging studies of oral functions, or summarise the mechanisms underlying oral diseases (but see Refs for a detailed review on this aspect). The article consists of the following sections: Two clinical examples, mastication and dental fear, are presented to highlight the advantages of using neuroimaging to unravel the association between the brain and oral behaviours of the patients. The general pros and cons of neuroimaging—focusing on MRI‐based neuroimaging methods—are presented.…”

Section: Introductionmentioning

confidence: 99%

What do we learn from brain imaging?—A primer for the dentists who want to know more about the association between the brain and human stomatognathic functions

Lin

Yeung

2020

J of Oral Rehabilitation

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The number of neuroimaging studies on the brain and oral sensorimotor functions has increased recently. Behind the dazzling "brain maps," what does the neuroimaging evidence truly tell us? What can dentists learn from it to improve clinical practice?We summarise the pros and cons of applying magnetic resonance imaging (MRI)based neuroimaging to study oral behaviours of the dental patients. This is a narrative review of previous neuroimaging research of oral functions, focusing on MRI-related studies of human subjects. MRI has gained popularity in dental research due to its non-invasive nature, its approachability and its versatility in quantifying a variety of brain signatures. We argue that MRI-based neuroimaging is suitable for investigating the association between the between-individual variations in brain structure (eg grey matter volume)/brain functions (eg brain activation) and oral behaviours of the patients. Two specific topics of the daily dental practice, mastication and dental fear and anxiety, are discussed to exemplify the potential of neuroimaging methods. The methodological and interpretive limitations of MRI techniques are highlighted, and most importantly, we emphasise that the neuroimaging findings should be carefully interpreted given these limitations. MRI-based neuroimaging techniques can provide a better evaluation of the association between the brain and stomatognathic functions, which could be pivotal to the evidence-based clinical management of dental patients. K E Y W O R D Sbrain, magnetic resonance imaging, neuroimaging, oral medicine, stomatognathic system

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“…It is a common condition; studies in Brazil [3] and Hong Kong [4] found that over 40% of the population had experienced orofacial pain. Because of the complexity of the affected regions, orofacial pain can have a deleterious effect on the patients' daily functions (including eating, drinking, and speaking) and can seriously affect various social functions and the quality of life [5,6].…”

Section: Introductionmentioning

confidence: 99%

The medial thalamus plays an important role in the cognitive and emotional modulation of orofacial pain: a functional magnetic resonance imaging-based study

Jin

Yang

Zhang

et al. 2020

Preprint

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Background The thalamus plays a critical role in the perception of orofacial pain. We investigated the neural mechanisms of orofacial pain by exploring the intrinsic functional alterations of the thalamus and assessing the changes in functional connectivity (FC) between the thalamic subregions with significant functional alterations and other brain regions in orofacial pain using the seed-based FC approach. Methods The study comprised 49 participants in the orofacial pain group and 49 healthy controls. Orofacial pain was caused by orthodontic separators. The resting-state functional magnetic resonance imaging data of the two groups were analyzed to obtain the fractional amplitude of low-frequency fluctuations (fALFFs) of the thalamus, and the thalamic subregions with significant fALFF abnormalities were used as seeds for FC analysis. Student’s t-tests were used to perform comparisons. Pearson’s correlation analysis was performed using SPM software. Results Forty-four participants with orofacial pain (mean age, 21.0±0.9 years; 24 women) and 49 age- and sex-matched healthy controls (mean age, 21.0±2.6 years; 27 women) were finally included. Compared with the control group, the orofacial pain group demonstrated (1) increased function in the dorsal thalamus and decreased function in the medial thalamus; (2) decreased FC between the medial thalamus and 12 brain regions (p<0.05, family-wise error corrected, voxel>100); and (3) potential positive and negative correlations between the medial thalamus-seeded FC and visual analog scale score changes (p<0.05, AlphaSim corrected). Conclusions The findings show that the medial and dorsal thalamus play important roles in orofacial pain perception and that the medial thalamus likely plays an important role in the cognitive and emotional modulation of orofacial pain.

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Chronic orofacial pain

Cited by 23 publications

References 27 publications

An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve

An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve

What do we learn from brain imaging?—A primer for the dentists who want to know more about the association between the brain and human stomatognathic functions

The medial thalamus plays an important role in the cognitive and emotional modulation of orofacial pain: a functional magnetic resonance imaging-based study

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