“…In the third cross-sectional study that evaluated for genetic and nongenetic factors associated with the severity of constipation in cancer patients receiving opioids (n ¼ 1568), 25 age, gender, body mass index, cancer diagnosis, time on opioids, opioid dose, and type of opioid did not contribute to interindividual differences in constipation severity. However, the nongenetic factors associated with constipation in patients receiving laxatives were type of laxative, decreased mobility, and place of care.…”