Effects of Ionising Radiation on Micronucleus Formation and Chromosomal Aberrations in Chinese Radiation Workers

Qin, Qian; Cao, Xiaohong; Shen, Fuhai; Wang, Qian

doi:10.1093/rpd/ncv290

Cited by 24 publications

(21 citation statements)

References 38 publications

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“…Our results are consistent with previously published literature. Qian et al,16 found that personnel working with x-rays have a higher MN count than the control group of healthy adults without history of expose to radiation, which similar to the results found in this study, where the exposed group had a higher MN number per 1000 cells compared to the non-exposed group (Table 2). We have also found that individuals working in x-ray centers have been exposed to more radiation than permitted by national guidelines.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México

Padilla-Raygoza

Gutiérrez

Martínez

et al. 2019

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Introduction: Occupational exposure to ionizing radiation can potentially lead to adverse health effects, including cancer and genetic defects. Genetic damage caused by radiation can be detected if micronuclei are observed. The objective of this pilot study was to detect the presence of micronuclei in cells of the oral mucosa in inidividuals occupationally exposed to ionizing radiation.Methods: We implemented a pilot case-control study in which we compared oral mucosa micronuclei in 30 medical and nursing personnel in radiology centers in Celaya, Mexico, with 30 volunteers not exposed to ionizing radiation recruited from a public University. The oral mucosa was brushed and the amount of micronuclei was quantified. Chi-square test or t-test for two proportions were used to compared ionizing radiation and genetic damage between exposed and non-exposed groups.Results: The exposed group had an average of 5.37 ± 3.49 micronuclei and the non-exposed had 0.37 ± 0.61 (P<0.01). In the exposed group, 90% of participants exhibited genetic damage compared to 6.67% in the unexposed group (P<0.05).Conclusion: In this pilot study, medical and nursing staff from radiology centers presented with higher genetic damage compared to control group. Further studies are needed to identify the prevalence of genetic damage due to occupational radiation exposure in Mexico.

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Section: Discussionsupporting

confidence: 89%

Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México

Padilla-Raygoza

Gutiérrez

Martínez

et al. 2019

cajgh

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“…However, this finding can be supported by something known as “radiation hormesis model,” which assumes that adaptive/protective mechanisms can be stimulated over time by low-dose radiation and that they can prevent the occurrence of mutations in the cells (Vaiserman, 2010). Evidence of hormesis throughout defined low-dose IR ranges was previously described (Crump et al, 2012; Gaetani et al, 2018; Qian et al, 2016; Sahin et al, 2009; Sakly et al, 2012; Ündeǧer et al, 1999).…”

Section: Discussionmentioning

confidence: 76%

Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation

et al. 2020

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The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifestyle factors. Blood and buccal samples were collected from 36 workers, who actively participated in an imaging sector of a hospital, who were either exposed to IR directly or indirectly (9 internal control and 27 exposed), and 27 individuals living in the same city but with no occupational exposure (external control, unexposed/healthy). All radiation dosages performed on the 36 workers were less than 20 mSv/y, not exceeding the effective dose limit for occupational exposure. A questionnaire identified socioeconomic and lifestyle factors associated with the outcomes. The results of the MN assay showed a significant difference between both internal control and the exposed group when compared to the external control. For the comet assay, there were significant differences between the percent of tail DNA of the exposed group and external controls, but no difference was found between the exposed group and internal controls. Relative risk associations were found in time of exposure, hours worked per week, and perceived stress. Correlations were found between the outcomes and age, consumption of alcohol, and frequencies of X-rays during life. Variables that showed to be significant in the adjusted analysis were skin color and recent exposure to radiation. Albeit limited, the findings of this study suggest genotoxicity in both blood and buccal mucosa cells of workers exposed directly or indirectly to IR and that lifestyle and socioeconomic factors are associated and correlated with the risk of developing these outcomes.

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“…This is due to the longer working period caused the increase in equivalent doses accumulation which received by radiation workers. A previous study by Qian et al (2015) stated that radiation workers with >20 years of exposure time had higher MN frequencies compared to radiation workers with <20 years of exposure time. Syaifudin et al (2017) also stated that the MN frequencies after irradiation of lymphocytes increased with the increased radiation dose, mainly for higher doses (>2 Gy).…”

Section: Discussionmentioning

confidence: 92%

Association between XRCC1 exon 10 (Arg399Gln) gene polymorphism and micronucleus as a predictor of DNA damage among radiation workers

et al. 2018

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Surniyantoro HNE, Lusiyanti Y, Rahardjo T, Nurhayati S, Tetriana D. 2018. Association between XRCC1 exon 10(Arg399Gln) gene polymorphism and micronucleus as a predictor of DNA damage among radiation workers. Biodiversitas 19: 1676-1682. This study was aimed to examine the association between XRCC1 exon 10 gene polymorphism and micronucleus frequencies inradiation workers and their relation to the confounding factors. This study involved 37 radiation workers and 37 controls from severalhospitals in Indonesia. Genotyping of X-ray cross-complementing group 1 (XRCC1) exon 10 gene polymorphism and micronucleusassay were performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Cytokinesis-Block Micronucleus assay (CBMN assay), respectively. The results indicated that MN frequencies were not significantly higher in theexposed workers than in controls (20.46±6.42 versus 16.89 ±9.72; P=0.07). The micronucleus frequencies of radiation workers withmutant genotype showed not significantly higher than controls in the same genotypes (22±6.64 versus 11.75 ± 8.13; P=0.11). Theconfounding factors, like age, years of employment and equivalent doses were significantly associated with micronucleus frequencies(P<0.05). The equivalent dose has a significantly positive correlation with micronucleus frequencies among radiation workers,increasing the MN frequencies by 16.3 per 1 mSv of equivalent dose (P=0.001). The genetic polymorphism of XRCC1 gene exon 10demonstrated no association with the extent of DNA damage in the hospital radiation workers. The MN frequencies were stronglyassociated with age, equivalent dose and years of employment.

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Effects of Ionising Radiation on Micronucleus Formation and Chromosomal Aberrations in Chinese Radiation Workers

Cited by 24 publications

References 38 publications

Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México

Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México

Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation

Association between XRCC1 exon 10 (Arg399Gln) gene polymorphism and micronucleus as a predictor of DNA damage among radiation workers

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