Isolation of an Angiotensin I-Converting Enzyme Inhibitory Protein with Antihypertensive Effect in Spontaneously Hypertensive Rats from the Edible Wild Mushroom Leucopaxillus tricolor

Geng, Xiao; Gao, Tian; Zhang, Weiwei; Zhao, Yongchang; Zhao, Liyan; Ryu, Mansok; Wang, Hexiang; Ng, Tzi Bun

doi:10.3390/molecules200610141

Cited by 19 publications

(14 citation statements)

References 33 publications

(40 reference statements)

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“…Obesity affects individuals progressively, and later leads to morbidity and mortality. The incorporation of obesity, hypertension, and atherosclerosis has two key complications [ 29 ]. Initially, this combination is most dangerous for patients with obesity and high blood pressure that have elevated incidence of CVD, including coronary artery disease, carditis, cardiomyopathy, cardiac arrhythmia, end-stage renal disease, stroke, and obstructive sleep apnea [ 30 ].…”

Section: Pathologies Associated With Obesity and Its Effects On Hementioning

confidence: 99%

“…The circulating levels of sex-hormone-binding globulin helps elevate the amounts of E2 and T that can readily diffuse across to target cells through binding with estrogen and androgen receptors. Ultimately, they inhibit apoptosis and promote cellular proliferation in the breast epithelium and endometrium [ 29 ]. Obesity leads to hyperinsulinemia and diabetes, which in turn to produce AGE causing a pro-inflammatory state by NF-χB, protein kinase, and intracellular adhesion molecules.…”

Section: Pathologies Associated With Obesity and Its Effects On Hementioning

confidence: 99%

“…Based on the reduction of NO and more leucocyte infiltration in the vessels this causes endothelial and microvascular dysfunction, which are influenced by oxidative stress (ROS), eventually causing atherosclerosis and hypertension [ 30 , 32 ]. In addition, obesity elevates excess glucose and fatty acid oxidation levels that lead to lipid peroxidation and ROS generation, which facilitate lipoprotein toxicity and enhances the rate of hypertension and formation of plaque in blood vessels [ 27 , 28 , 29 , 30 ].…”

Section: Pathologies Associated With Obesity and Its Effects On Hementioning

confidence: 99%

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Anti-Obesity Effects of Medicinal and Edible Mushrooms

Ganesan

2018

Molecules

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Obesity is a group of metabolic disorders caused by multiple factors, including heredity, diet, lifestyle, societal determinants, environment, and infectious agents, which can all lead to the enhancement of storage body fat. Excess visceral fat mass in adipose tissue generate several metabolic disorders, including cardiovascular diseases with chronic inflammation based pathophysiology. The objective of the current review is to summarize the cellular mechanisms of obesity that attenuate by antioxidant potentials of medicinal and edible mushrooms. Studies have showed that mushrooms potentially have antioxidant capacities, which increase the antioxidant defense systems in cells. They boost anti-inflammatory actions and thereby protect against obesity-related hypertension and dyslipidemia. The practice of regular consumption of mushrooms is effective in the treatment of metabolic syndrome, including obesity, and thus could be a good candidate for use in future pharmaceutical or nutraceutical applications.

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Section: Pathologies Associated With Obesity and Its Effects On Hementioning

confidence: 99%

Section: Pathologies Associated With Obesity and Its Effects On Hementioning

confidence: 99%

Section: Pathologies Associated With Obesity and Its Effects On Hementioning

confidence: 99%

See 1 more Smart Citation

Anti-Obesity Effects of Medicinal and Edible Mushrooms

Ganesan

2018

Molecules

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“…Additionally, the water extract of the edible wild mushroom Leucopaxillus tricolor exhibited a clear antihypertensive effect on spontaneously hypertensive rats [103]. Besides, both Cordyceps sinensis and Ganoderma lucidum mushrooms show antinociceptive activity.…”

Section: Other Bioactivities Of Mushroomsmentioning

confidence: 99%

Bioactivities and Health Benefits of Mushrooms Mainly from China

et al. 2016

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Many mushrooms have been used as foods and medicines for a long time. Mushrooms contain polyphenols, polysaccharides, vitamins and minerals. Studies show that mushrooms possess various bioactivities, such as antioxidant, anti-inflammatory, anticancer, immunomodulatory, antimicrobial, hepatoprotective, and antidiabetic properties, therefore, mushrooms have attracted increasing attention in recent years, and could be developed into functional food or medicines for prevention and treatment of several chronic diseases, such as cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases. The present review summarizes the bioactivities and health benefits of mushrooms, and could be useful for full utilization of mushrooms.

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“…Mushrooms are abundant in bioactive compounds comprising proteases (Hu et al, 2012;Moon et al, 2014;Zheng et al, 2011), lectins (Wang et al, 2013;Xu et al, 2014;Zhang et al, 2014b), angiotensin I-converting enzyme inhibitory peptides (Geng et al, 2015;Kang et al, 2013;Lau et al, 2014;Mohamad Ansor et al, 2013), ribonucleases (Xu et al, 2013;Zhang et al, 2014a), acid phosphatases (Wannet et al, 2000;Zhang et al, 2013), laccases (Tian et al, 2012;Xu et al, 2015a;Xu et al, 2015b), antifungal proteins (Suzuki et al, 2011;Wong et al, 2010), and polysaccharides (Liu et al, 2014a;Ma et al, 2014;Mao et al, 2014;Zhu et al, 2014). Many of these mushroom proteins have potential applications or health-promoting activities in human (Liu et al, 2014b;Wu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Purification and characterization of a novel metalloprotease from fruiting bodies of Oudemansiella radicata

Geng

Gao

et al. 2017

Acta Biochim Pol

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In this study, a 39-kDa metalloprotease was purified from a rare edible mushroom with health-promoting activities, Oudemansiella radicata, using a purification protocol which entailed anion exchange chromatography on DEAE-cellulose and Q-Sepharose columns and gel filtration by fast protein liquid chromatography on a Superdex 75 column. Some peptide sequences were obtained by LC-MS/MS analysis and one of the sequences, DAWIQADVNR, manifested 90% identity to Coprinopsis cinerea metalloprotease. The optimal reaction pH and temperature for Oudemansiella radicata protease were pH 7.0 and 50°C, respectively. The protease was purified 79-fold and demonstrated a specific protease activity of 2.42 U/mg. The K of the purified protease for the casein substrate was 0.65 mg/mL at pH 7.0 and 50°C. The activity of the protease was inhibited by Cd, Hg, Cu, Pb and Fe ions, but was enhanced by K, Mn and Fe ions. The marked suppression of the protease activity by EDTA indicates that the protease is a metalloprotease.

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Isolation of an Angiotensin I-Converting Enzyme Inhibitory Protein with Antihypertensive Effect in Spontaneously Hypertensive Rats from the Edible Wild Mushroom Leucopaxillus tricolor

Cited by 19 publications

References 33 publications

Anti-Obesity Effects of Medicinal and Edible Mushrooms

Anti-Obesity Effects of Medicinal and Edible Mushrooms

Bioactivities and Health Benefits of Mushrooms Mainly from China

Purification and characterization of a novel metalloprotease from fruiting bodies of Oudemansiella radicata

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