Brain Abscess Caused by Bacillus megaterium in an Adult Patient

Guo, Fengjin; Fan, Hongwei; Liu, Zhengyin; Yang, Qiwei; Li, Yijia; Li, Taisheng

doi:10.4103/0366-6999.157697

Cited by 17 publications

(7 citation statements)

References 4 publications

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“…B. megaterium was also implicated in a case of ovarian mass torsion [ 2 ], which suggested that the bacterium entered the bloodstream and then localized to the ovary. A similar hypothesis was also proposed in a case of B. megaterium -related brain abscess [ 7 ], highlighting the pathogenic potential of this organism. This hypothesis is also supported by the demonstration of B. megaterium attachment and subsequent invasion of human erythrocytes [ 13 ].…”

Section: Discussionsupporting

confidence: 68%

“…While the recovery of B. anthracis in any infection is deemed a serious health threat, the finding of B. megaterium in clinical specimens should not be brushed aside as an insignificant contaminant [ 1 ]. We found four previously reported clinical cases related to B. megaterium [ 1 , 2 , 7 , 8 ] from the literature, listed in chronological order in Table 1 . Including the isolate in this study, three out of the five cases were wound infections.…”

Section: Discussionmentioning

confidence: 99%

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Penicillin-Susceptible, Oxidase-Negative, Nonhemolytic, NonmotileBacillus megateriumin Disguise ofBacillus anthracis

Loong

Teoh

Johari

et al. 2017

Case Reports in Infectious Diseases

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Bacillus anthracis is a bacterial pathogen of major concern. The spores of this bacteria can survive harsh environmental conditions for extended periods and are well recognized as a potential bioterror weapon with significant implications. Accurate and timely identification of this Bacillus species in the diagnostic laboratory is essential for disease and public health management. Biosafety Level 3 measures and ciprofloxacin treatment were instituted when B. anthracis was suspected from a patient with gangrenous foot. 16S rDNA sequencing was performed to accurately identify the suspected bacterium, due to the superiority of this method to accurately identify clinically isolated bacteria. B. megaterium was identified as the causative agent and the organism was subsequently treated as a Biosafety Level 2 pathogen.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Penicillin-Susceptible, Oxidase-Negative, Nonhemolytic, NonmotileBacillus megateriumin Disguise ofBacillus anthracis

Loong

Teoh

Johari

et al. 2017

Case Reports in Infectious Diseases

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“… 47 Similarly, Guo et al. 48 reported B. megaterium causes brain abscess in adult patients. In rare cases, B. flexus causes infections in burn patients.…”

Section: Discussionmentioning

confidence: 97%

Molecular characterization and antimicrobial susceptibility of bacterial isolates present in tap water of public toilets

Kaur

Singh

Kesavan

et al. 2019

International Health

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Background The present study was carried out to investigate the tap water quality of public toilets in Amritsar, Punjab, India. Methods Water samples from the taps of the public toilets were collected in sterile containers and physicochemical and bacteriological analysis was performed using standard methods. Also, genotypic and phenotypic characterization of the bacterial isolates was performed using different biochemical tests and 16S ribosomal RNA analysis. An antibiotic susceptibility test was performed using antibiotics based on their mode of action. A biofilm assay was performed to assess the adhesion potential of the isolates. Results A total of 25 bacterial isolates were identified from the water samples, including Acinetobacter junii, Acinetobacter pittii, Acinetobacter haemolyticus, Bacillus pumilus, Bacillus megaterium, Bacillus marisflavi, Bacillus flexus, Bacillus oceanisediminis, Pseudomonas otitidis, Pseudomonas sp. RR013, Pseudomonas sp. RR021, Pseudomonas sp. RR022, Escherichia coli and Enterobacter cloacae. The results of the antimicrobial susceptibility test revealed that the antibiotics cefodroxil, aztreonam, nitrofurantoin, cefepime, ceftazidime and amoxyclav were found to be mostly ineffective against various isolates. The biofilm assay revealed the weak, moderate and strong biofilm producers among them. Conclusions The tap water in the public toilets was microbially contaminated and needs to be monitored carefully. The antibiotic susceptibility profile showed that of 25 bacterial isolates, 5 were multidrug resistant. Bacterial isolates exhibited strong to weak adhesion potential in the biofilm assay.

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“…In 2011, Duncan and Smith reported the case of a 25-yearold woman who presented with a primary cutaneous infection caused by B. megaterium, probably acquired by micro abrasions on the skin [4]. Finally, in 2015, Guo et al reported the case of a 50-year-old woman who developed a brain abscess related to an infection with B. megaterium [5]. In this case, the method of entrance was not clear, as in our case report.…”

Section: Discussionmentioning

confidence: 99%

Pleuritis with pleural effusion due to a Bacillus megaterium infection

Crisafulli

Aredano

Valzano

et al. 2018

Respirology Case Reports

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Pleural effusions may be related to pleuro‐pulmonary or systemic disorders, including malignancy. Thoracentesis and thoracoscopy may be useful to diagnosis. In some cases, the diagnosis may be difficult and uncommon. We report the case of a hospitalized male for a pleuritis, with pleural effusion caused by a Bacillus megaterium infection, a Gram‐positive, aerobic, spore‐forming, and rod‐shaped bacterium. To our knowledge, our case report is the first evidence of pleuritis due to B. megaterium. In the literature, up to now, B. megaterium infection has only been reported as involving the eye, skin, and brain.

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Brain Abscess Caused by Bacillus megaterium in an Adult Patient

Cited by 17 publications

References 4 publications

Penicillin-Susceptible, Oxidase-Negative, Nonhemolytic, NonmotileBacillus megateriumin Disguise ofBacillus anthracis

Penicillin-Susceptible, Oxidase-Negative, Nonhemolytic, NonmotileBacillus megateriumin Disguise ofBacillus anthracis

Molecular characterization and antimicrobial susceptibility of bacterial isolates present in tap water of public toilets

Pleuritis with pleural effusion due to a Bacillus megaterium infection

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