Pleuritis with pleural effusion due to a <scp><i>Bacillus megaterium</i></scp> infection

Crisafulli, Ernesto; Aredano, Ilaria; Valzano, Ilaria; Burgazzi, Barbara; Andrani, Francesco; Chetta, Alfredo

doi:10.1002/rcr2.381

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…Four papers described human cases where immunosuppression or particular disease features explain the Bacillus spp. clinical manifestations: (i) one paper (Kim et al, 2018) describes a case of pyometra in an immunosuppressed dog, (ii) one paper (Crisafulli et al, 2019) described pleuritic lesions caused by B. megaterium in an old patient with underlying disease, (iii) a case of a 5-year-old immunocompetent patient with a deep skin abscess due to B. licheniformis and related to a retained plant thorn (Yuste et al, 2016), (iv) cases due to infection with B. flexus hospitalised in a burns unit (Ucar et al, 2016);…”

Section: Bacillus Species With Qps Statusmentioning

confidence: 99%

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA (2017–2019)

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2020

EFS2

243

207

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The qualified presumption of safety (QPS) was developed to provide a safety pre‐assessment within EFSA for microorganisms. Strains belonging to QPS taxonomic units (TUs) still require an assessment based on a specific data package, but QPS status facilitates fast track evaluation. QPS TUs are unambiguously defined biological agents assessed for the body of knowledge, their safety and their end use. Safety concerns are, where possible, to be confirmed at strain or product level, and reflected as ‘qualifications’. Qualifications need to be evaluated at strain level by the respective EFSA units. The lowest QPS TU is the species level for bacteria, yeasts and protists/algae, and the family for viruses. The QPS concept is also applicable to genetically modified microorganisms used for production purposes if the recipient strain qualifies for the QPS status, and if the genetic modification does not indicate a concern. Based on the actual body of knowledge and/or an ambiguous taxonomic position, the following TUs were excluded from the QPS assessment: filamentous fungi, oomycetes, streptomycetes, Enterococcus faecium, Escherichia coli and bacteriophages. The list of QPS‐recommended biological agents was reviewed and updated in the current opinion and therefore now becomes the valid list. For this update, reports on the safety of previously assessed microorganisms, including bacteria, yeasts and viruses (the latter only when used for plant protection purposes) were reviewed, following an Extensive Literature Search strategy. All TUs previously recommended for 2016 QPS list had their status reconfirmed as well as their qualifications. The TUs related to the new notifications received since the 2016 QPS opinion was periodically evaluated for QPS status in the Statements of the BIOHAZ Panel, and the QPS list was also periodically updated. In total, 14 new TUs received a QPS status between 2017 and 2019: three yeasts, eight bacteria and three algae/protists.

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Section: Bacillus Species With Qps Statusmentioning

confidence: 99%

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA (2017–2019)

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2020

EFS2

243

207

View full text Add to dashboard Cite

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“…Three papers have serious methodological problems in relation to strain identification and source attribution (Joshi et al., ; Shah et al., ) and are not food related (Aydin et al., ). Two papers have a methodological problem in relation to strain identification and present a bacteraemia case caused by B. licheniformis in an old and immunocompromised patient (of Li et al., ) and a pleuritic caused by B. megaterium in an old patient with underlying diseases (Crisafulli et al., ). The paper of Gu et al.…”

Section: Assessmentmentioning

confidence: 99%

“…It has a high nutritional value (Tibbetts et al, 2015) and is of considerable interest for biotechnological production of useful compounds, e.g. essential fatty acids, antioxidants (carotenoids and phenolic compounds), starch and bulk lipids and oils (Araujo et al, 2011;Cust odio et al, 2012;Gifuni et al, 2018). Genetic tools for transformation of T. chuii have been developed ( Ubeda-M ınguez et al, 2015).…”

Section: Body Of Knowledgementioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 11: suitability of taxonomic units notified to EFSA until September 2019

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2020

EFS2

View full text Add to dashboard Cite

Qualified presumption of safety (QPS) was developed to provide a generic safety evaluation for biological agents to support EFSA's Scientific Panels. The taxonomic identity, body of knowledge, safety concerns and antimicrobial resistance are assessed. Safety concerns identified for a taxonomic unit (TU) are where possible to be confirmed at strain or product level, reflected by ‘qualifications’. No new information was found that would change the previously recommended QPS TUs and their qualifications. The list of microorganisms notified to EFSA was updated with 54 biological agents, received between April and September 2019; 23 already had QPS status, 14 were excluded from the QPS exercise (7 filamentous fungi, 6 Escherichia coli, Sphingomonas paucimobilis which was already evaluated). Seventeen, corresponding to 16 TUs, were evaluated for possible QPS status, fourteen of these for the first time, and Protaminobacter rubrum, evaluated previously, was excluded because it is not a valid species. Eight TUs are recommended for QPS status. Lactobacillus parafarraginis and Zygosaccharomyces rouxii are recommended to be included in the QPS list. Parageobacillus thermoglucosidasius and Paenibacillus illinoisensis can be recommended for the QPS list with the qualification ‘for production purposes only’ and absence of toxigenic potential. Bacillus velezensis can be recommended for the QPS list with the qualifications; the absence of toxigenic potential and the absence of aminoglycoside production, including the genes encoding this. Cupriavidus necator, Aurantiochytrium limacinum and Tetraselmis chuii can be recommended for the QPS list with the qualification; for production purposes only. Pantoea ananatis is not recommended for the QPS list due to lack of body of knowledge in relation to its pathogenicity potential for plants. Corynebacterium stationis, Hamamotoa singularis, Rhodococcus aetherivorans and Rhodococcus ruber cannot be recommended for the QPS list due to lack of body of knowledge. Kodamaea ohmeri cannot be recommended for the QPS list due to safety concerns.

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“…Moreover, B. megaterium strain SAmt17 produces extracellular polymeric substances that suppress the expression of hepatocyte carcinoma G2 cells, and strain ATCC 13368 produces four cytotoxic compounds suppressing human melanoma cells. Infections caused by B. megaterium are rare; only five cases (eye, skin, brain, pleuritis with pleural effusion [ 40 ], and soft tissue infections [ 41 ]) have been described in the literature so far. In the present study, we detected B. megaterium in two lung tumor tissue samples.…”

Section: Discussionmentioning

confidence: 99%

Metatranscriptomic Analysis of Human Lung Metagenomes from Patients with Lung Cancer

Chang

Hsu

et al. 2021

Genes

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This study was designed to characterize the microbiomes of the lung tissues of lung cancer patients. RNA-sequencing was performed on lung tumor samples from 49 patients with lung cancer. Metatranscriptomics data were analyzed using SAMSA2 and Kraken2 software. 16S rRNA sequencing was also performed. The heterogeneous cellular landscape and immune repertoires of the lung samples were examined using xCell and TRUST4, respectively. We found that nine bacteria were significantly enriched in the lung tissues of cancer patients, and associated with reduced overall survival (OS). We also found that subjects with mutations in the epidermal growth factor receptor gene were less likely to experience the presence of Pseudomonas. aeruginosa. We found that the presence of CD8+ T-cells, CD4+ naive T-cells, dendritic cells, and CD4+ central memory T cells were associated with a good prognosis, while the presence of pro B-cells was associated with a poor prognosis. Furthermore, high clone numbers were associated with a high ImmuneScore for all immune receptor repertoires. Clone numbers and diversity were significantly higher in unpresented subjects compared to presented subjects. Our results provide insight into the microbiota of human lung cancer, and how its composition is linked to the tumor immune microenvironment, immune receptor repertoires, and OS.

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Pleuritis with pleural effusion due to a Bacillus megaterium infection

Cited by 10 publications

References 5 publications

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA (2017–2019)

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA (2017–2019)

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 11: suitability of taxonomic units notified to EFSA until September 2019

Metatranscriptomic Analysis of Human Lung Metagenomes from Patients with Lung Cancer

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