Synchronous malignant renal mass in patient with a Lung cancer: case report and literature review

Abstract

The finding on imaging (computed tomography scan or magnetic resonance imaging) of synchronous malignant renal mass in patient with an active nonrenal malignancy without renal specific symptoms is not frequent and diagnostic evaluation can be challenging. We describe a 54-year-old Moroccan male former chronic smoker who presented to our hospital with dry cough and impairment of the performance status. The imaging found a tumor mass in the left upper lobe of the lung associated to mediastinal lymph node and a scanno-guided biopsy of this tumor showed a non small cell lung cancer. The radiological staging revealed a solitary renal mass in the right kidney. The patient received firstly two cycles of a lung cancer chemotherapy with a partial response in the lung and a stability of the renal mass. Consequently, he underwent a scanno-guided biopsy of this mass which confirmed a synchronous clear cell renal carcinoma. The patient got chemo radiotherapy for the lung cancer and then after that he got a partial nephrectomy. He is still under a good control with more than 2 years after the initial diagnosis.

Synchronous Oligometastatic Non-Small Cell Lung Cancer and Isolated Renal Cell Carcinoma: A Case Report and Literature Review

“…However, a lack of hypermetabolic activity does not rule out the possibility of a primary RCC. PET imaging has been described to have a low sensitivity to detect primary renal malignancies, which was consistent with the experience of Mazouz, et al and with our own findings in the present case [ 6 - 7 ]. Although renal metastases are typically bilateral and multi-focal, they can also present as a large, solitary metastasis in breast, lung, and colorectal patients [ 8 ].…”

“…There have been a limited number of published cases reporting on the diagnostic and therapeutic approach to synchronous primary pulmonary and renal neoplasms. Similar to our case, a report from the Netherlands described a patient with a TTF-1 positive adenocarcinoma of the right lower lobe of the lung invading into the thoracic vertebrae that presented synchronously with an 18-FDG-negative lesion in the right kidney [ 6 ]. Initially, the case was considered to be Stage IV NSCLC with the renal mass representing a distant metastasis and, as such, was managed with an expectative approach.…”

Synchronous Oligometastatic Lung Acinar Adenocarcinoma and Clear Cell Renal Cell Carcinoma: A case report

“…The patients with a nonrenal primary tumour with a long-life expectancy and a single small renal mass are more likely to benefit from surgical extirpation over a biopsy. 8 In this case, urology had proposed radical nephrectomy, which the patient did not accept at first. Knowing that surgery is the gold standard treatment for primary renal neoplasm 10 , we may consider that this decision delayed the treatment; however, nephrectomy was eventually performed upon histological confirmation of the malignancy and this delay had no implications in the final outcome.…”

Successful first-line treatment of simultaneous multiple primary malignancies of lung adenocarcinoma and renal clear cell carcinoma: A case report

“…Renal cell carcinoma has a relatively low incidence in China, ranking 14th in incidence and 15th in mortality of malignant tumors ( 3 ), among the subtypes, the clear cell type is the most common, accounting for about 70% of renal cell carcinoma ( 4 ). While lung cancer combined with primary renal cell carcinoma, only a few cases have been reported ( 5 – 7 ). For such Multiple Primary Malignancies (MPMs), the diagnosis must meet two criteria.…”