Synchronous Oligometastatic Non-Small Cell Lung Cancer and Isolated Renal Cell Carcinoma: A Case Report and Literature Review

Nguyen, Timothy; Louie, Alexander V.

doi:10.7759/cureus.366

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Palliative radiotherapy was also planned due to massive hemoptysis. Similar to our case, Nguyen and Louie (11) observed an oligometastatic papillary adenocarcinoma of the lung with solitary brain metastasis in the setting of a synchronous primary renal neoplasm in a 58-year-old gentleman. Their case subsequently underwent pulmonary lobectomy, intracranial resections, and partial nephrectomy, respectively.…”

Section: Discussionsupporting

confidence: 88%

Primary Adenocarcinoma of Lung with Synchronous Renal Cell Carcinoma: A Case Report and Review of the Literature

et al. 2020

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Introduction: The simultaneous occurrence of two distinct tumors is rare. Distinguishing between the concomitances of two primary malignancies from metastatic disease is very important for disease management and overall survival improvement. Case Presentation: We report a case of a lung adenocarcinoma patient, who incidentally has renal cell carcinoma (RCC). This report includes clinical, radiological, and histological diagnostic challenges in an unexpected lesion and a review of the literature. Conclusions: The possibility of primary cancer should be taken into account when a lesion is detected in the lung or the kidneys. Thus, both the radiographic appearance and clinical behavior of a lesion may hold clues that can help distinguish synchronous cancers.

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Section: Discussionsupporting

confidence: 88%

Primary Adenocarcinoma of Lung with Synchronous Renal Cell Carcinoma: A Case Report and Review of the Literature

et al. 2020

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(S049) Internal Validation of the Prognostic Index for Spine Metastasis (PRISM) for Stratifying Survival in Patients Treated With Spinal Stereotactic Radiosurgery

Jensen

Tang

Hess

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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Results: Sixty-one pediatric patients were treated with CNS re-irradiation. Primary diagnoses included ependymoma (nZ18,30%), medulloblastoma/ PNET (nZ15,25%), germ cell tumor (nZ8,13%), infratentorial high grade glioma (nZ6,10%), supratentorial low grade glioma (nZ3,5%), supratentorial high grade glioma (nZ3,5%), infratentorial low grade glioma (nZ2,3%), and other (nZ6,10%). Median age at first course of RT was 8.5 years (range 0.5-19.5 years) and 12.3 years (range 3.3-30.2 years) at time of re-irradiation. Initial dose of RT was 54Gy in 47 patients (77%) and <54Gy in 14 patients (23%). Median time between initial and re-irradiation courses was 2.0 years. Location of relapse was infield in 45 patients and marginal/distant in 16 patients. Thirty-five patients (57%) underwent gross-or sub-total resection at time of recurrence. Techniques for reirradiation were IMRT (nZ40), 3D-RT (nZ9), SBRT (nZ4, 12-13Gyx1 or 5 Gyx5), protons (nZ4), combined modality (nZ2), 2D-RT (nZ1), and brachytherapy (nZ1). Conventional fractionation re-irradiation courses were 54Gy in 17 patients (28%) and <54Gy in 39 patients (72%). Radiation necrosis was detected in 2 cases after first course of RT and 2 additional patients after re-irradiation. Median overall survival following end of re-irradiation was 12.8 months in the entire cohort, 14.6 and 9.0 months for patients treated with radical versus palliative intent, respectively, and 20.5 and 8.4 months for patients with recurrent ependymoma and medulloblastoma following re-irradiation. Conclusions: CNS re-irradiation in pediatric patients may be a reasonable treatment option with moderate survival noted following repeat RT; although, prospective data characterizing rates of local control and toxicity are needed.

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Synchronous Oligometastatic Non-Small Cell Lung Cancer and Isolated Renal Cell Carcinoma: A Case Report and Literature Review

Cited by 2 publications

References 15 publications

Primary Adenocarcinoma of Lung with Synchronous Renal Cell Carcinoma: A Case Report and Review of the Literature

Primary Adenocarcinoma of Lung with Synchronous Renal Cell Carcinoma: A Case Report and Review of the Literature

(S049) Internal Validation of the Prognostic Index for Spine Metastasis (PRISM) for Stratifying Survival in Patients Treated With Spinal Stereotactic Radiosurgery

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