Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells

Federzoni, Elena; Gloor, Severin; Jin, Jing; Shan-Krauer, Deborah; Fey, Martin F.; Torbett, Bruce E.; Tschan, Mario P.

doi:10.1016/j.lrr.2015.04.002

Cited by 1 publication

(1 citation statement)

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“…1C). Additionally, the expression of CEBPE mRNA, a marker of successful granulocyte/neutrophil differentiation [25,26], was higher in miR-136-transfected HL60 and NE4 cells than the cells transfected with control oligoes (Fig. 1D).…”

Section: Mir-136 Promotes Expression Of Cd11b and Cd14 During Hematopoietic Differentiationmentioning

confidence: 95%

TNF-α-mediated microRNA-136 induces differentiation of myeloid cells by targeting NFIA

Mei¹,

Liu²,

Wu³

et al. 2015

Journal of Leukocyte Biology

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Immune cell-lineage specification and function are influenced by progenitor origin and environmental factors. The mechanism of differentiation of immune cells, such as neutrophils, monocytes, and myeloid-derived suppressor cells, in inflammatory environments has not been elucidated completely. In this study, we have identified human microRNA-136 as a positive regulator of the differentiation of granulocytes and monocytes. Ectopic microRNA-136 induced cells to express higher levels of CD11b, CD14, and C/EBPε, secrete more cytokines, and synthesize higher levels of reactive oxygen species and H(2)O(2). microRNA-136 was shown to target and degrade multiple differentiation-associated molecules, such as the transcription factor NFIA, which induced the release of another microRNA, microRNA-223, with the ability to promote CD11b expression. Furthermore, microRNA-136 expression was remarkably increased by TNF-α, which activated NF-κB to bind to the DNA-promoter region controlling microRNA-136 expression. Additionally, TNF-α may alter NFIA expression through its modulation of microRNA-136 expression. Thus, TNF-α-mediated microRNA-136 may play a critical role in the generation and differentiation of inflammatory immune cells.

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Section: Mir-136 Promotes Expression Of Cd11b and Cd14 During Hematopoietic Differentiationmentioning

confidence: 95%