Cord blood vitamin D concentrations are unrelated to atopy and wheeze in 2 diverse birth cohort studies

Visness, Cynthia M.; Sandel, Megan; O’Connor, George T.; Gern, James E.; Jaffee, Katy F.; Wood, Robert A.; Kattan, Meyer; Bloomberg, Gordon R.; Dresen, Amy; Gergen, Peter J.; Gold, Diane R.; Lemanske, Robert F.; Rajamanickam, Victoria; Camargo, Carlos A.; Jackson, Daniel J.

doi:10.1016/j.jaci.2015.03.046

Cited by 18 publications

(16 citation statements)

References 10 publications

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“…From 547 records retrieved by our search, 34 articles published between 2008 and 2017 were finally included (Figure ). Articles are based on 26 separate study populations, including 25 longitudinal birth cohorts and one case‐control study, from 16 different countries (latitude ranging from 55ºN to 31ºS) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Overall 16 studies examined the relationship between prenatal vitamin D levels with offspring's risk of asthma from 3 to 14 years of age . Based on the available data, an inverse association between prenatal exposure to vitamin D and risk of asthma in offspring was found, but it did not reach statistical significance.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen records examined the association between prenatal 25(OH)D circulating levels with offspring's risk of allergic sensitization from age 1 to 7 years . The results of available data showed no association between prenatal vitamin D status and risk of allergic sensitization in the offspring during childhood.…”

Section: Resultsmentioning

confidence: 99%

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Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Pacheco-Gonzalez

García‐Marcos

Morales

2018

Pediatric Allergy Immunology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Pacheco-Gonzalez

García‐Marcos

Morales

2018

Pediatric Allergy Immunology

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“…24 In recent analyses in 2 high-risk birth cohorts, one of urban, largely minority, and low-income children (Urban Environment and Childhood Asthma [URECA]) 25 and one of largely suburban white children (Childhood Origins of Asthma [COAST]), 26 cord blood concentrations of 25(OH)D were not associated with risk of asthma, wheeze, or atopic outcomes in the first 6 years of life. 27 …”

Section: Perinatal Risk Factorsmentioning

confidence: 99%

Lessons learned from birth cohort studies conducted in diverse environments

Jackson

Gern

Lemanske

2017

Journal of Allergy and Clinical Immunology

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Birth cohort studies have produced significant advances toward understanding how genetic and environmental factors contribute to the inception of asthma and related allergic diseases. Histopathologic, physiologic, microbiologic, and immunologic findings indicate that critical developmental windows exist in which these various factors either alone or in concert induce the expression of the childhood asthma phenotype. The microbiome in early life clearly influences immune development and asthma. Early environmental exposures, including those related to the home, parents, siblings, pets, and pests, are all likely to influence patterns of microbial colonization and also might shape immune responses to allergens and viruses. As with other contributing factors, there appear to be windows of opportunity in early life when microbial exposures have the greatest effect on these processes. Recent studies of bacterial metabolic products and their effects might suggest new strategies for immune modulation in early life.

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“…Cord blood vitamin D level and multi-trigger wheezing, wheezing and risk of troublesome lung symptoms development have been reported to be reversely correlated in three different studies [35,36]. However, recent two different birth cohort studies showed that cord blood vitamin D concentrations were unrelated to atopy and wheeze [37].…”

Section: Natal Umblical Cord Vitamin D Level and Wheezing Developmentmentioning

confidence: 99%

Vitamin D and Allergy

Özdemir¹

2016

MOJI

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After the modern vitamin D hypothesis firstly suggested in 1999 for the allergy pandemic, numerous conditions have been thought to be associated with vitamin D deficiency such as allergy, autoimmunity and neoplasm. Consistently, previous observational studies have linked lower vitamin D status to increased markers of atopy and allergic diseases e.g. atopic dermatitis, anaphylaxis and food allergy. Vitamin D is a "hormone" having important immunomodulatory and immunoregulatory properties. In vitamin D deficient conditions, disrupted mucosal and skin complex integrity and intercurrent infections may act synergistically with allergenic exposure to amplify sensitization risk. There has been emerging data to show that vitamin D can enhance the anti-inflammatory effects of glucocorticoids and potentially be used as adjuvant therapy in steroid-resistant severe asthma. And recent in vivo data suggest that vitamin D supplementation reduce the severity of eczema and allergic rhinitis as well as urticaria symptoms. However, there is presently inadequate evidence to support daily vitamin D supplementation in the prevention and/or treatment of allergic diseases in infants, children and adolescents.

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Cord blood vitamin D concentrations are unrelated to atopy and wheeze in 2 diverse birth cohort studies

Cited by 18 publications

References 10 publications

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Lessons learned from birth cohort studies conducted in diverse environments

Vitamin D and Allergy

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