Immunology and Infection by Protozoan Parasites

Cunha-Neto, Edécio; Chevillard, Christophe; Rodrigues, Maurício M.; Bozza, Marcelo T.

doi:10.1155/2015/504951

Cited by 2 publications

(2 citation statements)

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“…While most of these infections occur in developing countries, it is evident that developed countries are also affected [67] . In addition, the emergence of anti-microbial resistant strains, toxicity, and low effectiveness of the currently available treatments pose a substantial problem [68] . Globalization and socioeconomic conditions also play a major role in the emergence and spreading of specific protozoan parasitic infections [69] .…”

Section: Human Protozoan Parasitic Diseasesmentioning

confidence: 99%

Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter

Jha¹,

Holcomb²,

McDaniel³

et al. 2022

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The vascular endothelium is a vital component in maintaining the structure and function of blood vessels. The endothelial cells (ECs) mediate vital regulatory functions such as the proliferation of cells, permeability of various tissue membranes, and exchange of gases, thrombolysis, blood flow, and homeostasis. The vascular endothelium also regulates inflammation and immune cell trafficking, and ECs serve as a replicative niche for many bacterial, viral, and protozoan infectious diseases. Endothelial dysfunction can lead to vasodilation and pro-inflammation, which are the hallmarks of many severe diseases. Exosomes are nanoscale membrane-bound vesicles that emerge from cells and serve as important extracellular components, which facilitate communication between cells and maintain homeostasis during normal and pathophysiological states. Exosomes are also involved in gene transfer, inflammation and antigen presentation, and mediation of the immune response during pathogenic states. Protozoa are a diverse group of unicellular organisms that cause many infectious diseases in humans. In this regard, it is becoming increasingly evident that many protozoan parasites (such as Plasmodium , Trypanosoma, Leishmania , and Toxoplasma) utilize exosomes for the transfer of their virulence factors and effector molecules into the host cells, which manipulate the host gene expression, immune responses, and other biological activities to establish and modulate infection. In this review, we discuss the role of the vascular endothelium and exosomes in and

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Section: Human Protozoan Parasitic Diseasesmentioning

confidence: 99%

Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter

Jha¹,

Holcomb²,

McDaniel³

et al. 2022

Vessel Plus

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show abstract

“…Protozoan infection is one of the most common parasitic infections in humans and plays a very important role in worldwide morbidity and mortality ( 1 ). Protozoan infections are found around the world but are mainly concentrated in developing countries.…”

Section: Introductionmentioning

confidence: 99%

The roles of COX-2 in protozoan infection

2023

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Protozoan diseases cause great harm in animal husbandry and require human-provided medical treatment. Protozoan infection can induce changes in cyclooxygenase-2 (COX-2) expression. The role played by COX-2 in the response to protozoan infection is complex. COX-2 induces and regulates inflammation by promoting the synthesis of different prostaglandins (PGs), which exhibit a variety of biological activities and participate in pathophysiological processes in the body in a variety of ways. This review explains the roles played by COX-2 in protozoan infection and analyzes the effects of COX-2-related drugs in protozoan diseases.

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Immunology and Infection by Protozoan Parasites

Cited by 2 publications

References 0 publications

Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter

Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter

The roles of COX-2 in protozoan infection

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