Use of depot medroxyprogesterone acetate and prevalent leiomyoma in young African American women

Harmon, Quaker E.; Baird, Donna D.

doi:10.1093/humrep/dev069

Cited by 31 publications

(22 citation statements)

References 20 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Factors involved in the initiation of UL are being studied using animal models [36–39]. A large prospective study of African-American women aged 23–34 years in Detroit is on-going to study risk factors and exposures present before UL diagnosis (screened with ultrasound) [40, 41]. …”

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

“…The BWHS replicated this association, reporting a 40% reduced risk (95% CI 0.4–0.9) comparing current users of progestin-only injectables with non-users of hormonal contraception [78]. A cross-sectional analysis from the Study of Environment Lifestyle and Fibroids (SELF), an ultrasound screening study of young African American women, also found an inverse association between DMPA and UL (adjusted RR: 0.8, 95% CI: 0.6, 0.9) [40]. The effect of DMPA is likely mediated through the lower estradiol concentrations which resemble those of postmenopausal women; in addition, estradiol suppression increases with longer duration of DMPA use [147].…”

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of Uterine Fibroids

Wise

Laughlin-Tommaso

2016

Clinical Obstetrics &Amp; Gynecology

262

122

View full text Add to dashboard Cite

Uterine leiomyomata (UL) have a substantial impact on women's health, but relatively few studies have identified opportunities for primary prevention of these neoplasms. Most established risk factors are not modifiable, including premenopausal age, African ancestry, age at menarche, and childbearing history. The main challenge in studying UL is that a large proportion of tumors are asymptomatic. Herein, we review the epidemiology of UL from published studies to date. We highlight the advantages of ultrasound screening studies and the ways in which their innovative methods have helped clarify the etiology of disease. We conclude with a discussion of promising new hypotheses.

show abstract

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

Epidemiology of Uterine Fibroids

Wise

Laughlin-Tommaso

2016

Clinical Obstetrics &Amp; Gynecology

262

122

View full text Add to dashboard Cite

show abstract

“…It has been established that incidence rates of myoma are higher among Black women, but the biologic basis is unclear [ 5 ]. Birth and Depo-Provera (a contraceptive method for women) use has been shown to decrease myoma risk [ 4 , 8 ]; likewise, a diet rich in vegetables, fruit and soya food has been associated with decreased frequency of myoma [ 7 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption and risk of uterine myoma: A systematic review and meta analysis

et al. 2017

View full text Add to dashboard Cite

BackgroundThe published data about alcohol consumption and uterine myoma are scanty and controversial: some studies found positive association whereas other studies showed no association.ObjectivesTo conduct a systematic review and meta-analysis to determine whether alcohol is a risk factor for myoma.Search strategyA MEDLINE/EMBASE search was carried out, supplemented by manual searches of bibliographies of the selected studies.Selection criteriaArticles published as full-length papers in English. In the review we included all identified studies. Otherwise, the inclusion criteria for studies included in the meta-analysis were: a) case-control or cohort studies, reporting original data; b) studies reporting original data on the association between alcohol consumption and myoma; c) diagnosis of myoma was ultrasound or histological confirmed and/or clinically based.Data collection and analysisA total of 6 studies were identified for the review and 5 studies were included in the meta-analysis. The primary outcome was the incidence of uterine myoma in ever versus never alcohol drinkers and when data were available, we also analyzed categories of alcohol intake. We assessed the outcomes in the overall population and then we performed a subgroup analysis according to study design. Pooled estimates of the odds ratios (OR) with 95% confidence interval (CI) were calculated using random effects models.Main resultsThe summary OR (95%CI) of myoma forever versus never alcohol intake was 1.12 (0.94–1.34) with significant heterogeneity. The summary OR for current versus never drinking was 1.33 (1.01–1.76) with no heterogeneity.ConclusionsEver alcohol consumption is not associated with myoma risk. Based on the data of two studies, current alcohol drinkers had a slightly borderline increased risk of diagnosis of myoma. In consideration of the very limited number of studies and the suggestion of a potential increased risk among current drinkers, further studies are required.

show abstract

“…These monoclonal tumors are nearly nonexistent in childhood and have an indolent course after menopause, thus strongly implicating gonadal hormones in leiomyoma formation, growth, and maintenance (2). Limiting gonadal hormone exposure results in changes in cell signaling pathways and protein expression that are thought to be involved in inhibiting fibroid formation and growth (3)(4)(5). For this reason, management with the use of antihormone therapies make up the majority of effective medical regimens available to patients with symptomatic uterine fibroids.…”

mentioning

confidence: 99%

Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma

Parikh

Malik

Britten

et al. 2020

Fertility and Sterility

View full text Add to dashboard Cite

Objective: To characterize the role of steroid hormone and antihormone exposure on neurotrimin (NTM) expression in human leiomyoma and myometrial tissue and cells. Design: Laboratory study of placebo and ulipristal acetate (UPA)-treated patient tissue. In vitro assessment of immortalized myometrial and leiomyoma cell lines after hormone and antihormone exposure. Setting: Academic research center. Patient(s): Not applicable. Interventions(s): Exposure of leiomyoma cell lines to 17b-E 2 , medroxyprogesterone acetate (MPA), UPA, and fulvestrant. Main Outcome Measure(s): Messenger RNA expression quantified with the use of RNASeq analysis and quantitative real-time polymerase chain reaction (qRT-PCR). Protein levels quantified by means of Western blot analysis. Immunohistochemistry (IHC) on placebo-and UPA-treated patient uterine tissue specimens. Result(s): Expression of NTM in human uterine leiomyoma specimens according to RNASeq was increased compared with myometrium (5.22 AE 0.57-fold), which was confirmed with the use of qRT-PCR (1.95 AE 0.05). Furthermore, NTM protein was elevated in leiomyoma tissue compared with matched myometrium (2.799 AE 0.575). IHC revealed increased staining intensity in leiomyoma surgical specimens compared with matched myometrium of placebo patients. Western blot analysis in immortalized leiomyoma cell lines demonstrated an up-regulation of NTM protein expression (2.4 AE 0.04). Treatment of leiomyoma cell lines with 17b-E 2 yielded a 1.98 AE 0.11-fold increase in NTM protein expression; however, treatment with fulvestrant showed no significant change compared with control. Leiomyoma cell lines demonstrated a 1.91 AE 0.97-fold increase in NTM protein expression after progesterone treatment. RNASeq analysis demonstrated a reduced expression in patient leiomyoma after UPA treatment (0.75 AE 0.14). Treatment of leiomyoma cells with UPA demonstrated a reduced total NTM protein amount (0.54 AE 0.31) in patients, which was confirmed with the use of IHC (UPA10 147.2 AE 9.40, UPA20 182.8 AE 8.98). In vitro studies with UPA treatment revealed a concentration-dependent effect that supported these findings. Conclusion(s): NTM, a neural cell adhesion molecule, is increased in leiomyoma compared with myometrium in patient tissue and in vitro models after estrogen and progesterone treatment. Down-regulation of expression occurs after UPA treatment, but not after fulvestrant exposure.

show abstract

Use of depot medroxyprogesterone acetate and prevalent leiomyoma in young African American women

Abstract: N/A.

Cited by 31 publications

References 20 publications

Epidemiology of Uterine Fibroids

Epidemiology of Uterine Fibroids

Alcohol consumption and risk of uterine myoma: A systematic review and meta analysis

Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma

Contact Info

Product

Resources

About