Improving Survival in Patients Treated for a Lung Cancer Using Self-Evaluated Symptoms Reported Through a Web Application

Denis, Fabrice; Yossi, S.; Septans, Anne-Lise; Charron, Alexandre; Voog, Éric; Dupuis, Olivier; Ganem, G.; Pointreau, Y.; Letellier, Christophe

doi:10.1097/coc.0000000000000189

Cited by 86 publications

(64 citation statements)

References 15 publications

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“…A recent randomized controlled trial by Denis and colleagues has shown a significant median overall survival benefit of 5 months for lung cancer patients who were systematically telemonitored using a mobile app based on patient-reported data and using the dynamics of patients’ clinical symptoms for risk stratification and individualized follow-up [ 18 , 35 ]. Similar approaches have successfully been used in the management of toxicities related to head and neck cancer treatment: computerized screening could facilitate the identification of treatment-related toxicities, and telepractice apps or videoconferencing could assist in the delivery of intensive home-based dysphagia therapy [ 24 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Supportive Care in Radiotherapy Based on a Mobile App: Prospective Multicenter Survey

Shafie

Weber

Bougatf

et al. 2018

JMIR Mhealth Uhealth

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BackgroundConsumer electronics and Web-enabled mobile devices are playing an increasing role in patient care, and their use in the oncologic sector opens up promising possibilities in the fields of supportive cancer care and systematic patient follow-up.ObjectiveThe objective of our study was to assess the acceptance and possible benefits of a mobile app–based concept for supportive care of cancer patients undergoing radiotherapy.MethodsIn total, 975 patients presenting for radiotherapy due to breast or prostate cancer were screened; of them, 200 owned a smartphone and consented to participate in the survey. Patients were requested to complete a questionnaire at 2 time points: prior to the initiation (T0) and after the completion (T1) of radiotherapy. The questionnaire included questions about the habits of smartphone usage, technical knowledge and abilities of the participants, readiness to use a mobile app within the context of radiotherapy, possible features of the mobile app, and general attitude toward the different aspects of oncologic treatments. For quantitative analysis, sum scores were calculated for all areas of interest, and results were correlated with patient characteristics. Additionally, answers were quantitatively compared between time points T0 and T1.ResultsMedian patient age was 57 (range 27-78) years. Of the 200 participants, 131 (66.2%) reported having the ability to use their smartphones with minimal to no help and 75.8% (150/200) had not used their smartphones in a medical context before. However, 73.3% (146/200) and 83.4% (166/200) of patients showed a strong interest in using a mobile app for supportive care during radiotherapy and as part of the clinical follow-up, respectively. Patients most commonly requested functionalities regarding appointment scheduling in the clinic (176/200, 88.0%) and the collection of patient-reported outcome data regarding their illness, therapy, and general well-being (130/200, 65.0%). Age was identified as the most influential factor regarding patient attitude, with patients aged <55 years being significantly more inclined toward and versed in smartphone use (P<.001). The acceptance of mobile apps was significantly higher in patients exhibiting a Karnofsky performance index <80% (P=.01). Support in the context of therapy-related side effects was judged most important by patients with poor clinical performance (P=.006). The overall acceptance of mobile apps in the context of radiotherapy surveillance was high at a median item sum score of 71.4/100 and was not significantly influenced by tumor stage, age, gender, treatment setting, or previous radiotherapies.ConclusionsThe acceptance of mobile apps for the surveillance and follow-up of cancer patients undergoing radiotherapy is high; this high acceptance level will serve as a basis for future clinical trials investigating the clinical benefits of mobile app–based treatment support. Introduction of mobile apps into the clinical routine should be considered as an opportunity to improve and intensify supportive ...

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Section: Discussionmentioning

confidence: 99%

Supportive Care in Radiotherapy Based on a Mobile App: Prospective Multicenter Survey

Shafie

Weber

Bougatf

et al. 2018

JMIR Mhealth Uhealth

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“…The primary outcome was overall survival after 2 years of follow-up, which was selected based on prior pilot research. 3 Survival data were gathered from patient follow-up by blinded investigators. After a preplanned interim analysis in January 2016 in which a significant survival improvement was observed, the data and safety monitoring committee mandated cessation of recruitment and crossover of control patients to the intervention.…”

mentioning

confidence: 99%

Two-Year Survival Comparing Web-Based Symptom Monitoring vs Routine Surveillance Following Treatment for Lung Cancer

Denis

Basch

Septans³

et al. 2019

JAMA

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397

375

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Symptom monitoring during chemotherapy via web-based patient-reported outcomes (PROs) was previously demonstrated to lengthen survival in a single-center study. 1 A multicenter randomized clinical trial compared web-based monitoring vs standard scheduled imaging to detect symptomatic recurrence in patients with lung cancer following initial treatment. A planned interim analysis (9-month follow-up) found a significant survival benefit (19-month survival in the PRO group vs 12 months in the control group). 2 We now present the final overall survival analysis.

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“…The multidimensional platform and its capabilities to combine electronic Patient-Reported Outcomes (PROs) with circadian rhythm monitoring and body weight measures meet the expectations of the American Society for Clinical Oncology, regarding the future of e-Health technologies in cancer medicine [52]. Thus, the weekly transmission of electronic PROs significantly improved overall survival in two randomized trials conducted in cancer patients, indicating this information might elicit initially unplanned interventions and/or modify patient's engagement with an oncologic benefit equivalent to that of the addition of an active drug [53,54]. The PiCADo platform provides a novel framework for the further integration of circadian rhythms and other parameters into proactive timely care interventions and the ready assessment of their efficacy.…”

Section: Discussionmentioning

confidence: 99%

Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study (Preprint)

Komarzynski¹,

Huang²,

Innominato³

et al. 2018

Preprint

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Improving Survival in Patients Treated for a Lung Cancer Using Self-Evaluated Symptoms Reported Through a Web Application

Abstract: Survival may be improved by early detection of relapse and early palliative care initiation by using sentinel-like Web-application.

Cited by 86 publications

References 15 publications

Supportive Care in Radiotherapy Based on a Mobile App: Prospective Multicenter Survey

Supportive Care in Radiotherapy Based on a Mobile App: Prospective Multicenter Survey

Two-Year Survival Comparing Web-Based Symptom Monitoring vs Routine Surveillance Following Treatment for Lung Cancer

Relevance of a Mobile Internet Platform for Capturing Inter- and Intrasubject Variabilities in Circadian Coordination During Daily Routine: Pilot Study (Preprint)

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