Fate and Transport of Molybdenum Disulfide Nanomaterials in Sand Columns

Lanphere, Jacob D.; Luth, Corey J.; Guiney, Linda M.; Mansukhani, Nikhita D.; Hersam, Mark C.; Walker, Sharon L.

doi:10.1089/ees.2014.0335

Cited by 20 publications

(14 citation statements)

References 56 publications

(65 reference statements)

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“…The concentrations of the MoS 2 solutions were measured using ICP-MS as described previously. [33] Briefly, MoS 2 solutions were digested overnight at 65 °C in nitric acid and subsequently diluted with water and internal standard. Using the ICP-MS measurements, concentration was inferred stoichiometrically.…”

Section: Methodsmentioning

confidence: 99%

Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

Wang

Mansukhani

Guiney

et al. 2015

Small

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110

101

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Two-dimensional molybdenum disulfide (MoS2) has distinct optical and electronic properties compared to aggregated MoS2, enabling wide use of these materials for electronic and biomedical applications. However, the hazard potential of MoS2 has not been studied extensively. Here, we present a comprehensive analysis of the pulmonary hazard potential of three aqueous suspended forms of MoS2: aggregated MoS2 (Agg-MoS2), MoS2 exfoliated by lithiation (Lit-MoS2) and MoS2 dispersed by Pluronic F87 (PF87-MoS2). No cytotoxicity was detected in THP-1 and BEAS-2B cell lines. However, Agg-MoS2 induced strong pro-inflammatory and pro-fibrogenic responses in vitro. In contrast, Lit- and PF87-MoS2 had little or no effect. In an acute toxicity study in mice, Agg-MoS2 induced acute lung inflammation, while Lit-MoS2 and PF87-MoS2 had little or no effect. In a sub-chronic study, there was no evidence of pulmonary fibrosis in response to all forms of MoS2. These data suggest that exfoliation attenuates the toxicity of Agg-MoS2, which is an important consideration towards the safety evaluation and use of nanoscale MoS2 materials for industrial and biological applications.

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Section: Methodsmentioning

confidence: 99%

Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

Wang

Mansukhani

Guiney

et al. 2015

Small

Self Cite

110

101

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“…In porous media, simulated by sand columns, the more mobile type of the particles was MoS 2 -Li (lithiated, compared with pluronic MoS 2 -PL). The less mobile MoS 2 -PL showed a tendency to aggregate and deposit on quartz media (sand), which may influence benthic organisms [39]. Taken together, limited data suggest that although clearance pathways depend on the nanoform and manufacturing method, MoS 2 should not be considered a putative environmental hazard.…”

Section: Ijomeh 2020;33(1)mentioning

confidence: 97%

Biological effects of molybdenum compounds in nanosized forms under <i>in vitro</i> and <i>in vivo</i> conditions

Sobańska¹,

Zapór²,

Szparaga³

et al. 2020

Int J Occup Med Environ Health

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Nanoparticles of transition metal dichalcogenides, particularly of molybdenum (Mo), have gained a lot of focus due to their exceptional physicochemical properties and the growing number of technological applications. These nanoparticles are also considered as potential therapeutic tools, biosensors or drug carriers. It is crucial to thoroughly examine their biocompatibility and ensure safe usage. The aim of this review is to analyze the available data on the biological effects of different nanoforms of elemental Mo and its compounds. In the reviewed publications, different conditions were described, including different experimental models, examined nanoforms, and their used concentrations. Due to these differences, the results are rather difficult to compare. Various studies classify Mo related nanomaterials as very toxic, mildly toxic or non-toxic. Similarly, the mechanisms of toxicity proposed in some studies are different, including oxidative stress induction, physical membrane disruption or DNA damage. Quite promising, however, are the potential medical applications of MoS 2 nanoparticles in therapy of cancer and Alzheimer's disease. Further studies on biocompatibility of nanomaterials based on Mo compounds are warranted.

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“…27, 110, 112, 124, 215, 326, 339 Here we focus on chemical transformations with the goal of identifying the material forms that will play the most important roles in the natural environment. This issue is informed by a decade of research on the environmental implications of particulate and 1D nanomaterials 340, 341 plus significant data on the environmental chemistry of natural 2D materials.…”

Section: Chemical Transformations In the Natural Environmentmentioning

confidence: 99%

Biological and environmental interactions of emerging two-dimensional nanomaterials

Wang¹,

Zhu²,

Qiu³

et al. 2016

Chem. Soc. Rev.

233

210

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Two-dimensional materials have become a major focus in materials chemistry research worldwide with substantial efforts centered on synthesis, property characterization, and technological application. These high-aspect ratio sheet-like solids come in a wide array of chemical compositions, crystal phases, and physical forms, and are anticipated to enable a host of future technologies in areas that include electronics, sensors, coatings, barriers, energy storage and conversion, and biomedicine. A parallel effort has begun to understand the biological and environmental interactions of synthetic nanosheets, both to enable the biomedical developments and to ensure human health and safety for all application fields. This review covers the most recent literature on the biological responses to 2D materials and also draws from older literature on natural lamellar minerals to provide additional insight into the essential chemical behaviors. The article proposes a framework for more systematic investigation of biological behavior in the future, rooted in fundamental materials chemistry and physics. That framework considers three fundamental interaction modes: (i) chemical interactions and phase transformations, (ii) electronic and surface redox interactions, and (iii) physical and mechanical interactions that are unique to near-atomically-thin, high-aspect-ratio solids. Two-dimensional materials are shown to exhibit a wide range of behaviors, which reflect the diversity in their chemical compositions, and many are expected to undergo reactive dissolution processes that will be key to understanding their behaviors and interpreting biological response data. The review concludes with a series of recommendations for high-priority research subtopics at the “bio-nanosheet” interface that we hope will enable safe and successful development of technologies related to two-dimensional nanomaterials.

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Fate and Transport of Molybdenum Disulfide Nanomaterials in Sand Columns

Cited by 20 publications

References 56 publications

Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

Biological effects of molybdenum compounds in nanosized forms under <i>in vitro</i> and <i>in vivo</i> conditions

Biological and environmental interactions of emerging two-dimensional nanomaterials

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