Correlation between the Serum Luteinizing Hormone to Folliclestimulating Hormone Ratio and the Anti-Müllerian Hormone Levels in Normo-ovulatory Women

Abstract

Serum anti-Müllerian hormone (AMH) levels are regarded as an age-specific marker for predicting the ovarian reserve in women of reproductive age. Some studies have shown that the luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio can be used as a predictor of ovarian reserve. The purpose of this study was to assess the variation of LH/FSH ratio with aging and to evaluate the correlation between serum LH/FSH ratio and AMH levels as a predictor of the ovarian reserve in normo-ovulatory women. We retrospectively analyzed the day 3 serum hormone levels in 1,251 patients (age range: 20-50 yr) between January 2010 and January 2011. We divided the patients into 6 groups according to their age. Relation between serum AMH level and LH/FSH ratio was analyzed statistically. The serum AMH level was inversely correlated with age (r = -0.400, P < 0.001). A significant negative correlation was found between serum LH/FSH ratio and age (r = -0.213, P < 0.001). There was a significant partial correlation between serum LH/FSH ratio and AMH level when adjusted by age (r = 0.348, P < 0.001). The LH/FSH ratio could be considered as a useful marker for the ovarian reserve and could be applied to the clinical evaluation with AMH.

Serum variations of anti-mullerian hormone and total testosterone with aging in healthy adult Iranian men: A population-based study

“…After controlling for age and BMI factors, the serum AMH levels had only negative significant correlation with FSH and LH; suggesting age-related reduced testicular function, that is in agreement with previous reports both in male [42] and female populations [43]. …”

Correlative Analysis Between Serum Anti-mullerian Hormone Concentration and LH:FSH Ratio as Women's Age Advances: A Hospital-based Study

“…Clinicians commonly use LH:FSH ra o in assessing the polycys c ovarian syndrome (PCOS) although we could not [22][23][24] prove the sufficient u lity of it in our study. In infer lity, researchers have shown the highest correla on of LH:FSH ra o with clinical pregnancy over other measures of ovarian 5,[25][26][27] reserve.…”

“…Human biologists describe it as a quan ty of ovarian follicular cohort 4 and quality of oocytes. Assessing an individual's ovarian reserve comprise with evalua on of certain variables like age, follicle s mula ng hormone (FSH), leu nizing hormone 5 (LH), LH:FSH ra o and prolac n (PRL) as main task. Recently, scien sts have studied serum an -mullerian hormone 6 (AMH) as poten al test for ovarian reserve.…”

Ovarian Reserve Markers: An Update

“…Interest in research on prediction of ovarian response in assisted reproductive techniques has increased in recent years. Lee et al [49] studied variations of AMH FSH, LH hormones in Korean women. This study described that basal LH/FSH ratio and AMH level has a valuable clinical meaning as an important predictor of ovarian response in IVF patients [49].…”

“…Lee et al [49] studied variations of AMH FSH, LH hormones in Korean women. This study described that basal LH/FSH ratio and AMH level has a valuable clinical meaning as an important predictor of ovarian response in IVF patients [49]. Furthermore, Cohen et al [10], Keane et al [50], Zebitay et al [51], Zheng et al [52], Goswami et al [53] and Spressão et al [54] have shown the important clinical application of AMH and AFC in the fertility counseling on infertile women correlated with pregnancy rates, live birth rates, number of retrieved eggs, fertilization rates and embryo development rates [10,[50][51][52][53][54].…”