Serum variations of anti-mullerian hormone and total testosterone with aging in healthy adult Iranian men: A population-based study

Abstract

BackgroundLiterature proves anti-mullerian hormone (AMH) and total testosterone (TT) as two important reproductive hormones in male development, however evidence regarding age variations of these hormones is lacking.AimsTo estimate the normal serum AMH values and to assess the age-specific TT levels in men aged 30–70, we conducted the present population-based study.MethodsA total of 831 healthy eligible men, aged 30–70 years, were recruited from Tehran Lipid and Glucose study cohort. Centiles for AMH were estimated according to the exponential normal 3-parameter model. The parametric method of Royston available in general software was applied for the first time to estimate the age-specific AMH and TT percentiles of 5th, 10th, 25th, 50th, 75th, 90th and 95th.ResultsMean AMH level was 6.93, ranging from 0.1 to 40.1 ng/ml. Serum AMH concentrations followed a steady reduction with increasing age. Mean TT level was 4.8, ranging from 0.44 to 11.4 ng/ml.DiscussionA measurable serum concentrations of AMH in healthy males throughout lifespan with variations, based on age, confirming a slight age-related AMH decline. Fractional polynomial (FP) regression models revealed that the mean and standard deviation (SD) of the TT were not associated with age, so the percentiles estimated were not age-specific.ConclusionWe presented a nomogram of age-specific AMH values in a healthy cohort of Iranian men. This finding might have clinical importance in dealing hormonal disorders in men.

Associations between Urinary Phthalate Metabolites and Serum Anti-Müller Hormone Levels in U.S. Men Based on National Health and Nutrition Examination Survey 2003–2004

“…The regression was not significant between phthalate metabolite concentrations and AMH in the WHOLE population. The main effect of age on serum and semen AMH level has been documented [ 23 ] and our results show that the level of AMH at the age above 60 is the lowest, as reported in the cross-sectional study [ 24 ]. As a result, we further divided the population into different age groups and did find significant regression in some age groups.…”

Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility

“…Testes, hormone production, and spermatogenesis undergo senescence as a man ages 98. Johnson et al 99 identified an age-related decrease in Sertoli cell number; consistent with this, AMH, as a marker of immature Sertoli cells, was also found to be reduced with increasing age36100101 and negatively correlated with FSH and LH, which indicates that decreased AMH levels as a man ages represent age-related reduced Sertoli cell function.…”

Premature ovarian aging in BRCA carriers: a prototype of systemic precocious aging?

“…AMH measurement have clinical advantage over measurements of other markers of ovarian aging, such as inhibin B, estradiol and follicle-stimulating hormone (FSH), which are all menstrual cycle dependent and mark only late ongoing process of primordial follicle pool depletion [ 20 ]. We have shown that serum AMH may serve as marker for testicular function after induced toxicity, whereas other groups demonstrated age dependent serum AMH reduction that may serve as marker for testicular aging and age-related reducing of testicular function [ 22 – 24 ]. Percentiles of AMH levels in females were determined according to AMH-nomograms of Tehrani et al [ 25 ].…”