Abstract:In typical magnetoencephalography and/or electroencephalography functional connectivity analysis, researchers select one of several methods that measure a relationship between regions to determine connectivity, such as coherence, power correlations, and others. However, it is largely unknown if some are more suited than others for various types of investigations. In this study, the authors investigate seven connectivity metrics to evaluate which, if any, are sensitive to audiovisual integration by contrasting … Show more
“…Other studies compared FC measures from the viewpoint of reproducibility (Colclough et al, 2016;Garcés et al, 2016), but more reproducible FC measures do not necessarily exhibit better performance for detecting FCs. In addition, in many of these studies (Dauwels et al, 2010;Mezeiová and Paluš, 2012;Ard et al, 2015;Colclough et al, 2016;Garcés et al, 2016;Lowet et al, 2016;Bakhshayesh et al, 2019), comparisons were made between different types of FC measures (e.g., amplitude envelope correlation and phase synchronization measures) or between FC measures and effective connectivity measures. However, because different types of FC measures have different functional roles (Mehrkanoon et al, 2014;Guggisberg et al, 2015), they should be regarded as complementary approaches.…”
Phase synchronization measures are widely used for investigating interregional functional connectivity (FC) of brain oscillations, but which phase synchronization measure should be chosen for a given experiment remains unclear. Using neuromagnetic brain signals recorded from healthy participants during somatosensory stimuli, we compared the performance of four phase synchronization measures, imaginary part of phase-locking value, imaginary part of coherency (ImCoh), phase lag index and weighted phase lag index (wPLI), for detecting stimulus-induced FCs between the contralateral primary and ipsilateral secondary somatosensory cortices. The analyses revealed that ImCoh exhibited the best performance for detecting stimulus-induced FCs, followed by the wPLI. We found that amplitude weighting, which is related to computing both ImCoh and wPLI, effectively attenuated the influence of noise contamination. A simulation study modeling noise-contaminated periodograms replicated these findings. The present results suggest that the amplitudedependent measures, ImCoh followed by wPLI, may have the advantage in detecting stimulus-induced FCs.
“…Other studies compared FC measures from the viewpoint of reproducibility (Colclough et al, 2016;Garcés et al, 2016), but more reproducible FC measures do not necessarily exhibit better performance for detecting FCs. In addition, in many of these studies (Dauwels et al, 2010;Mezeiová and Paluš, 2012;Ard et al, 2015;Colclough et al, 2016;Garcés et al, 2016;Lowet et al, 2016;Bakhshayesh et al, 2019), comparisons were made between different types of FC measures (e.g., amplitude envelope correlation and phase synchronization measures) or between FC measures and effective connectivity measures. However, because different types of FC measures have different functional roles (Mehrkanoon et al, 2014;Guggisberg et al, 2015), they should be regarded as complementary approaches.…”
Phase synchronization measures are widely used for investigating interregional functional connectivity (FC) of brain oscillations, but which phase synchronization measure should be chosen for a given experiment remains unclear. Using neuromagnetic brain signals recorded from healthy participants during somatosensory stimuli, we compared the performance of four phase synchronization measures, imaginary part of phase-locking value, imaginary part of coherency (ImCoh), phase lag index and weighted phase lag index (wPLI), for detecting stimulus-induced FCs between the contralateral primary and ipsilateral secondary somatosensory cortices. The analyses revealed that ImCoh exhibited the best performance for detecting stimulus-induced FCs, followed by the wPLI. We found that amplitude weighting, which is related to computing both ImCoh and wPLI, effectively attenuated the influence of noise contamination. A simulation study modeling noise-contaminated periodograms replicated these findings. The present results suggest that the amplitudedependent measures, ImCoh followed by wPLI, may have the advantage in detecting stimulus-induced FCs.
Connectivity estimates based on electroencephalography (EEG) and magnetoencephalography (MEG) are unique in their ability to provide neurophysiologically meaningful spectral and temporal information non-invasively. This multi-dimensional aspect of the MEG/EEG based connectivity increases the challenges of the analysis and interpretation of the data. Many MEG/EEG studies address this complexity by using a hypothesis-driven approach, which focuses on particular regions of interest (ROI). However, if an effect is distributed unevenly over a large ROI and variable across subjects, it may not be detectable using conventional methods. Here, we propose a novel approach, which enhances the statistical power for weak and spatially discontinuous effects. This results in the ability to identify statistically significant connectivity patterns with spectral, temporal, and spatial specificity while correcting for multiple comparisons using nonparametric permutation methods. We call this new approach the
P
ermutation
S
tatistics for
C
onnectivity
A
nalysis between
R
OI (PeSCAR). We demonstrate the processing steps with simulated and real human data. The open-source Matlab code implementing PeSCAR are provided online.
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