Changed crossmodal functional connectivity in older adults with hearing loss

Puschmann, Sebastian; Thiel, Christiane M.

doi:10.1016/j.cortex.2016.10.014

Cited by 48 publications

(52 citation statements)

References 66 publications

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“…The current study identified increased cross-modal functional connectivity between the left auditory cortex and both right and left visual cortices. The result is consistent with a recent study showing increased functional connectivity between left auditory cortex and right visual cortex in the elderly with hearing loss 52 . Additionally, the effect in the left hemisphere may be related to the use of speech stimuli.…”

Section: Discussionsupporting

confidence: 93%

Increased cross-modal functional connectivity in cochlear implant users

Chen

Puschmann

Debener

2017

Sci Rep

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Previous studies have reported increased cross-modal auditory and visual cortical activation in cochlear implant (CI) users, suggesting cross-modal reorganization of both visual and auditory cortices in CI users as a consequence of sensory deprivation and restoration. How these processes affect the functional connectivity of the auditory and visual system in CI users is however unknown. We here investigated task-induced intra-modal functional connectivity between hemispheres for both visual and auditory cortices and cross-modal functional connectivity between visual and auditory cortices using functional near infrared spectroscopy in post-lingually deaf CI users and age-matched normal hearing controls. Compared to controls, CI users exhibited decreased intra-modal functional connectivity between hemispheres and increased cross-modal functional connectivity between visual and left auditory cortices for both visual and auditory stimulus processing. Importantly, the difference between cross-modal functional connectivity for visual and for auditory stimuli correlated with speech recognition outcome in CI users. Higher cross-modal connectivity for auditory than for visual stimuli was associated with better speech recognition abilities, pointing to a new pattern of functional reorganization that is related to successful hearing restoration with a CI.

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Section: Discussionsupporting

confidence: 93%

Increased cross-modal functional connectivity in cochlear implant users

Chen

Puschmann

Debener

2017

Sci Rep

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“…Others have reported decreased activation of the contralateral auditory cortex and a reduced right-ear advantage with aging and presbycusis (Chen et al, 2016 ). Some fMRI studies have reported that age-related hearing loss increases the functional connectivity between the auditory cortex and right motion sensitive visual area during task and resting-state conditions (Puschmann and Thiel, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…Most prior studies have used fMRI to examine the effects of hearing loss on the brain activity during auditory tasks in presbycusis patients (Peelle et al, 2011 ; Husain et al, 2014 ; Profant et al, 2015 ; Chen et al, 2016 ; Puschmann and Thiel, 2017 ). Resting-state fMRI (rs-fMRI) is a powerful tool for evaluating spontaneous neural activity (Mantini et al, 2007 ) and rs-fMRI has been used to investigate brain functional connectivity alterations in the default mode network and dorsal attention network in middle-aged participants with hearing loss compared to controls (Husain et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI

Chen

Jiang

et al. 2018

Front. Behav. Neurosci.

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Purpose: Presbycusis, age-related hearing loss, is believed to involve neural changes in the central nervous system, which is associated with an increased risk of cognitive impairment. The goal of this study was to determine if presbycusis disrupted spontaneous neural activity in specific brain areas involved in auditory processing, attention and cognitive function using resting-state functional magnetic resonance imaging (fMRI) approach.Methods: Hearing and resting-state fMRI measurements were obtained from 22 presbycusis patients and 23 age-, sex- and education-matched healthy controls. To identify changes in spontaneous neural activity associated with age-related hearing loss, we compared the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) of fMRI signals in presbycusis patients vs. controls and then determined if these changes were linked to clinical measures of presbycusis.Results: Compared with healthy controls, presbycusis patients manifested decreased spontaneous activity mainly in the superior temporal gyrus (STG), parahippocampal gyrus (PHG), precuneus and inferior parietal lobule (IPL) as well as increased neural activity in the middle frontal gyrus (MFG), cuneus and postcentral gyrus (PoCG). A significant negative correlation was observed between ALFF/ReHo activity in the STG and average hearing thresholds in presbycusis patients. Increased ALFF/ReHo activity in the MFG was positively correlated with impaired Trail-Making Test B (TMT-B) scores, indicative of impaired cognitive function involving the frontal lobe.Conclusions: Presbycusis patients have disrupted spontaneous neural activity reflected by ALFF and ReHo measurements in several brain regions; these changes are associated with specific cognitive performance and speech/language processing. These findings mainly emphasize the crucial role of aberrant resting-state ALFF/ReHo patterns in presbycusis patients and will lead to a better understanding of the neuropathological mechanisms underlying presbycusis.

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“…On the other hand, the right MTG was no longer a hub in both the SHPT and Non-SHPT groups. The MTG is involved in several cognitive processes such as language and semantic memory processing and multimodal sensory integration [27][28][29][30]. Hubs play an important role in global information transfer and seem to be more vulnerable, since a stronger connection between hub regions leads to a higher probability of damage [31].…”

Section: Discussionmentioning

confidence: 99%

Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

Wang

Zou

et al. 2019

Preprint

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KEYWORDS 2 end-stage renal disease, secondary hyperparathyroidism, structural connectivity, topological organization, network Abstract Objective: The burden of cognitive impairment in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis has received more attention lately. It is associated with hospitalization, mortality and reduced quality of life. We aimed to assess the topological alterations of the brain white matter structural network in ESRD and the correlation between network metrics with Montreal Cognitive Assessment scores and clinical data. Methods: The study included 25 ESRD patients with secondary hyperparathyroidism (SHPT group), 25 patients without SHPT (Non-SHPT group) and 25 healthy controls (HC group) of comparable age and sex. Cognitive function was assessed using the Montreal Cognitive Assessment. The WM structural network was constructed by diffusion tensorimaging and a deterministic tractography method, and then we used graph theoretical approaches to investigate alterations in the global and regional properties of the WM networks in these participants.Results: ESRD patients showed cognitive impairment compared to HC, and the SHPT patients had lower cognitive scores than the Non-SHPT patients. The global topological organization and local efficiency of the WM network was significantly disrupted in the SHPT but not in the Non-SHPT patients compared with the HC group. Moreover, lower regional efficiency was found in the ESRD patients, mainly distributed in the frontal and parietal cortices. In addition, an association was found between iPTH, shortest path length and cognitive impairment, and the iPTH level was negatively correlated with small-worldness by two indexes, the normalized clustering coefficient and the normalized shortest path length. Conclusion: The present study indicated that the brain structural connectome in ESRD patients with high iPTH levels was disrupted in association with cognitive impairment and it is a potential connectome-based biomarker for early detection.

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Changed crossmodal functional connectivity in older adults with hearing loss

Cited by 48 publications

References 66 publications

Increased cross-modal functional connectivity in cochlear implant users

Increased cross-modal functional connectivity in cochlear implant users

Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI

Structural network topology correlates to cognitive impairment and iPTH level in End-stage renal disease patients with peritoneal dialysis

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