Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis, M.M.; Fortin, Chelsea N.; Zarek, Shvetha M.; Segars, James H.

doi:10.1007/s10815-014-0407-9

Cited by 39 publications

(34 citation statements)

References 80 publications

(156 reference statements)

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“…145,146 A systematic review of the literature on vitamin D and infertility found conflicting evidence on whether vitamin D improved ART outcomes, but that most studies supported vitamin D replacement, as there may be benefit with little risk. 147 There was one large trial that revealed the clinical pregnancy rate to be 41% after ART in vitamin D-deficient women, compared with a significantly higher pregnancy rate of 54% in women with normal vitamin D levels. 148 There are a lack of longitudinal studies and randomized control trials to evaluate whether vitamin D supplementation might prevent fibroids or decrease recurrence of fibroids after myomectomy.…”

Section: Vitamin Dmentioning

confidence: 99%

The Effect of Uterine Fibroids on Infertility: A Systematic Review

2017

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Fibroids are present in up to 27% of patients seeking reproductive assistance, and can affect fertility through cavity distortion, alteration of endometrial receptivity, and sexual function. Surgical, noninvasive, and medical approaches have been developed to manage fibroids, but evidence-based data regarding their safety and efficacy for the treatment of infertility and the effects on pregnancy outcome are limited. Myomectomy, through minimally invasive techniques, is the most evidence-based approach to fibroids in women planning conception, and increases pregnancy rates by up to 68% in previously infertile patients. Laparoscopic uterine artery occlusion is under investigation as an alternative and simpler surgical approach to decrease fibroid size. Uterine artery embolization is not recommended for women intending future pregnancy, as the rate of spontaneous abortion (SAB) is up to 64% and the rate of abnormal placentation is 12.5%. Magnetic resonance imaging–guided focused ultrasound surgery is gaining interest as a noninvasive procedure with positive preliminary pregnancy outcomes, but appears to have an SAB rate of 20.6%. Selective progesterone receptor modulators, aromatase inhibitors, and vitamin D supplementation are under investigation to improve uterine conditions for pregnancy. Submucosal and intramural fibroids affect fertility and pregnancy outcomes and should be addressed during infertility workup.

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Section: Vitamin Dmentioning

confidence: 99%

The Effect of Uterine Fibroids on Infertility: A Systematic Review

2017

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“…Current data on vitamin D status and assisted reproductive technology outcomes are conflicting, but the majority of studies support vitamin D supplementation in deficient patients (37). Vitamin D deficiency is correlated with female infertility and poor IVF outcomes (38,39).…”

Section: Figure 1: Roc Curve Analysis Of Vitamin Aed and B6 Levelsmentioning

confidence: 99%

The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction

Göde

Akarsu

Dikmen

et al. 2019

Gynecol Obstet Reprod Med

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Objective: To evaluate the associations among levels of vitamins A, E, D, and B6 in follicular fluid embryo morphokinetics and quality, and clinical pregnancy rates.Study Design: A total of 58 patients with unexplained infertility admitted to the in vitro fertilisation (IVF) centre of Izmir Medical Park Hospital were included in this prospective clinical study. For each patient, vitamin levels were assayed using high-performance liquid chromatography. After intracytoplasmic sperm injection, for each oocyte, the relationships between each vitamin and subsequent embryo quality, embryo morphokinetics, and clinical pregnancy rates were investigated. Embryos were classified as grade A, B, C, or D according to morphokinetic parameters using t5-t2 and t5-t3 (cc3). Results: There was no significant correlation between embryo morphokinetic parameters (tpnf, t2, t3, t4, t5, t6, t7 and t8) and follicular fluid vitamin (A, B6, D and E) levels (p>0.05). There was a significant positive correlation between t5optimal and follicular fluid vitamin A levels (p<0.05). There was a significant positive correlation between cc2optimal and follicular fluid vitamin B6 levels (p<0.05). Levels of vitamins A and B6 were significantly higher in grade A and B embryos than in grade C and D embryos. There were no significant relationships between vitamins E or D and embryo quality or between any vitamin and clinical pregnancy rates.Conclusion: High levels of vitamins A and B6 in follicular fluid are significantly associated with high-quality embryos and optimal morphokinetics. However, none of the vitamins considered showed a significant relationship with clinical pregnancy rates.

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“…60 In one study, female rats deficient in vitamin D experienced a 75% reduction in fertility. 61 62 Maternal vitamin D levels, in turn, have been investigated with regard to child health. Gestational and cord blood 25(OH) D concentrations have been associated with neurodevelopmental outcomes, such as mental or psychomotor development, among infants and toddlers in most, [63][64][65][66][67][68] but not all, 69 studies.…”

Section: Parental Obesitymentioning

confidence: 99%

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

Yeung¹,

Kim²,

Purdue-Smithe³

et al. 2018

Semin Reprod Med

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Concerns remain about the health of children conceived by infertility treatment. Studies to date have predominantly not identified substantial long-term health effects after accounting for plurality, which is reassuring given the increasing numbers of children conceived by infertility treatment worldwide. However, as technological advances in treatment arise, ongoing studies remain critical for monitoring health effects. To study whether the techniques used in infertility treatment cause health differences, however, remains challenging due to identification of an appropriate comparison group, heterogeneous treatment, and confounding by the underlying causes of infertility. In fact, the factors that are associated with underlying infertility, including parental obesity and other specific male and female factors, may be important independent factors to consider. This review will summarize key methodological considerations in studying children conceived by infertility treatment including the evidence of associations between underlying infertility factors and child health.

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Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Cited by 39 publications

References 80 publications

The Effect of Uterine Fibroids on Infertility: A Systematic Review

The Effect of Uterine Fibroids on Infertility: A Systematic Review

The Effect Follicular Fluid Vitamin A, E, D and B6 on Embryo Morphokinetics and Pregnancy Rates in Patients Receiving Assisted Reproduction

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?

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