Traffic pollution is associated with early childhood aeroallergen sensitization

Codispoti, Christopher D.; LeMasters, Grace K.; Levin, Linda; Reponen, Tiina; Ryan, Patrick; Myers, Jocelyn M. Biagini; Villareal, Manuel; Burkle, Jeff; Evans, Sherry; Lockey, James E.; Hershey, Gurjit K. Khurana; Bernstein, David I.

doi:10.1016/j.anai.2014.10.020

Cited by 54 publications

(36 citation statements)

References 43 publications

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“…Both factors may have contributed to odds ratio biased towards the null. Despite the differences in human health effects from different road types, our results further strengthen findings from prior studies that found traffic-related air pollution to be associated with, and likely a contributor of, asthmatic and allergic disease health outcomes (Codispoti and LeMasters, 2014; Delfino et al, 2014; Fuertes et al, 2013; Greenbaum, 2010; Jerrett and Shankardass, 2008; McConnell et al, 2010). …”

Section: Discussionsupporting

confidence: 86%

Allergic disease associations with regional and localized estimates of air pollution

Schultz

Schauer

Malecki

2017

Environmental Research

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Background: Exposure to multiple types of air pollution may contribute to and exacerbate allergic diseases including asthma and wheezing. However, few studies have examined chronic air pollution exposure and allergic disease outcomes among an adult population. Associations between potential estimates of annual average fine particulate matter (PM2.5), traffic related air pollution, and industrial source air emissions and three allergic disease outcomes (asthma, allergies and wheezing) were examined in a state-wide general population of adults. Methods: The study includes a representative sample of 3381 adult Wisconsin residents who participated in the 2008–2013 Survey of the Health of Wisconsin (SHOW) program. Participant data were geographically linked to The United States Environmental Protection Agency (USEPA) Baysian space-time downscaler air pollution model for PM2.5, the United States Census roadway, and USEPA's Toxic Release Inventory data. Self-report and lung function (FEV1) estimates were used to define prevalence of asthma, allergies and wheezing symptoms. Results: Annual mean exposure to fine particulate matter (PM2.5) was between 6.59 and 15.14 μg/m3. An increase of 5 μg/m3 in the annual mean PM2.5 resulted in a 3.58 (2.36, 5.43) increase in the adjusted odds (95% CI) of having asthma. Exposure to vehicle traffic increased the odds of both current allergies [OR (95% CI)=1.35 (1.07, 1.35)] and current asthma [OR (95% CI)=1.51 (1.14, 2.00)]. Living within 300 m of an Interstate roadway was associated with a 3-fold increase in the odds of asthma. Those living within 800 m of an industrial site were 47% more likely to have asthma. No significant associations were seen with wheezing. Conclusions: Within this population exposed to overall annual average levels of estimated low level chronic exposure to fine particulate matter (PM2.5) at or near 12 μg/m3, the USEPA standard for air quality, significant association between both modeled PM2.5 exposure and proximity to roadways with asthma and allergies but not wheezing were found. Industrial source emissions were not associated with any allergic disease outcomes.

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Section: Discussionsupporting

confidence: 86%

Allergic disease associations with regional and localized estimates of air pollution

Schultz

Schauer

Malecki

2017

Environmental Research

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“…The distance to the main road and the length and proportion of the main road within 200 meters of the home were all associated with allergic sensitization, defined as positive skin prick test (SPT) to an aeroallergen or food (20). Our data and others have also shown high TRAP exposure in the first year of life to increase the risk of aeroallergen sensitization by the age of four by 40–83% (29, 30). Children exposed to high TRAP levels before age 1 also have an increased risk of developing food allergy by age eight, particularly those that are not sensitized at age four (30).…”

Section: Epidemiology Of the Health Impact Of Trap On Allergic Diseasesupporting

confidence: 82%

Air pollution and allergic diseases

Brandt¹,

Myers²,

Ryan

et al. 2015

Current Opinion in Pediatrics

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Purpose of review Exposure to traffic-related air pollutants (TRAP) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant because increasingly large segments of the population worldwide reside in zones that have high levels of TRAP (1), including children since schools are often located in high traffic pollution exposure areas. Recent findings Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of traffic pollution on allergic diseases and the biology underlying this impact. In addition, new innovative methods to assess and quantify traffic pollution have been developed to assess exposure and identify vulnerable populations and individuals. Summary This review will summarize the most recent findings in each of these areas. These findings will have substantial impact on clinical practice and research by development of novel methods to quantify exposure and identify at-risk individuals, as well as mechanistic studies that identify new targets for intervention for individuals most adversely affected by TRAP exposure.

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“…DEPs can act as nonspecific airway irritants at high levels, while at lower levels, promote the release of allergic and inflammatory response mediators as well as reactive oxygen species in the upper and lower airway that lead to oxidative injury, and induce DNA damage, eventually compromising lung function [15, 34]. In addition, DEPs appear to enhance the immunological effects of environmental allergens, providing an explanation for the increased risk for asthmatic symptoms and respiratory dysfunction in children living near major sources of diesel pollution [13, 32]. …”

Section: Discussionmentioning

confidence: 99%

Respiratory Health Risks for Children Living Near a Major Railyard

et al. 2015

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Inland southern California is a region of public health concern, especially for children, given the area’s perennially poor air quality and increasing sources of local pollution. One elementary school specifically is located only a few hundred yards from the San Bernardino Railyard, one of the busiest goods movement facilities in California, potentially increasing respiratory problems. Through ENRRICH (Environmental Railyard Research Impacting Community Health) Project, we assessed association of proximity to a major freight railyard on adverse respiratory health in schoolchildren. Respiratory screening was provided for children at two elementary schools: one near the railyard and a socio-demographically matched comparison school 7 miles away. Screening included testing for airway inflammation (FeNO), lung function (peak expiratory flow, PEF) and parent reported respiratory symptoms. Parental questionnaires collected additional information. Log-binomial and linear regression assessed associations. Children attending school near the railyard were more likely to exhibit airway obstruction with higher prevalence of abnormal PEF (<80 %): prevalence ratio (PR) = 1.59 (95 % CI 1.19–2.12). The association with inflammation was less clear. Children at the exposure school, who had lived 6 months or longer at their current address (vs. all children at that school) were more likely to have values suggesting inflammation (FeNO > 20 ppb) (PR = 1.44, 95 % CI 1.02–2.02) and present with a trend for increased adverse respiratory symptoms. Children attending school near the railyard were significantly more likely to display respiratory health challenges. Ideally these low-income, low resource communities should be supported to implement sustainable intervention strategies to promote an environment where children can live healthier and thrive.

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Traffic pollution is associated with early childhood aeroallergen sensitization

Cited by 54 publications

References 43 publications

Allergic disease associations with regional and localized estimates of air pollution

Allergic disease associations with regional and localized estimates of air pollution

Air pollution and allergic diseases

Respiratory Health Risks for Children Living Near a Major Railyard

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