Air pollution and allergic diseases

Brandt, Eric B.; Myers, Jocelyn M. Biagini; Ryan, Patrick; Hershey, Gurjit K. Khurana

doi:10.1097/mop.0000000000000286

Cited by 62 publications

(54 citation statements)

References 108 publications

(123 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main source of outdoor NO 2 in China is traffic air pollution (TRAP). Our result agrees with the conclusion from a recent review article, concluding that TRAP, indicated as NO 2 levels, is a risk factor for rhinitis . Mean outdoor NO 2 concentrations in our study were above the WHO guidelines for NO 2 (40 µg/m 3 as annual average)…”

Section: Discussionsupporting

confidence: 92%

“…Finally, one time series analysis from Shanghai found that childhood allergic rhinitis outpatient visits increased with increased outdoor concentrations of O 3 , SO 2 , and PM 10 . Traffic‐related air pollution, indicated as NO 2 levels, is another important outdoor risk factor for rhinitis . In the large CCHH study among preschool children across China, rhinitis was associated with traffic‐related air pollution (NO 2 ), dampness or mold at home, environmental tobacco smoke (ETS), and living in a warmer climate zone …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Onset and remission of rhinitis among students in relation to the home and school environment—A cohort study from Northern China

Norbäck

Tian

et al. 2019

Indoor Air

View full text Add to dashboard Cite

Few prospective studies exist on indoor and outdoor air pollution in relation to adolescent rhinitis. We studied associations between onset and remission of rhinitis among junior high school students in relation to the home and school environment. A 2‐year questionnaire cohort study was performed among 1325 students (11‐15 years) in eight schools in Taiyuan, Northern China. Climate and air pollution were measured by direct reading instruments and passive samplers inside and outside the schools at baseline. Associations were calculated by multilevel logistic regression. Two‐year onset of rhinitis and weekly rhinitis were 26.7% and 13.1%, respectively. RH (P < 0.001), CO2 (P < 0.01) and PM10 (P < 0.01) in the classrooms, PM10 (P < 0.01) and NO2 (P < 0.05) outside the schools, and redecoration (OR = 2.25) and dampness/indoor mold at home (OR = 2.04) were associated with onset of weekly rhinitis. RH (P < 0.05) and CO2 (P < 0.05) in the classroom and dampness/indoor mold (OR = 0.67) and environmental tobacco smoke (ETS) at home (OR = 0.63) reduced remission of rhinitis. In conclusion, dampness/mold and chemical emissions from new materials at home can increase onset of rhinitis and ETS and dampness/mold can reduce the remission. PM10, RH, CO2, and NO2 at school can increase the onset, and RH and CO2 can reduce the remission of rhinitis.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Onset and remission of rhinitis among students in relation to the home and school environment—A cohort study from Northern China

Norbäck

Tian

et al. 2019

Indoor Air

View full text Add to dashboard Cite

show abstract

“…Historically, research was conducted on combustion-derived particles as reviewed recently (104, 105). The interaction of allergens with engineered NPs, such as Au, Ag, ZnO, TiO 2 , SiO 2 , may arise at sites where such materials are handled, so risk of disease-aggravating conditions can be expected in occupational settings.…”

Section: Allergymentioning

confidence: 99%

Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

et al. 2017

View full text Add to dashboard Cite

The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate ongoing reactions in various ways, including the delivery of substances aiming at providing a therapeutic benefit. We review, here, the state of knowledge concerning the interaction of NPs with type 2 immune responses and highlight their potential as a multifunctional platform for therapeutic intervention.

show abstract

“…Air pollutants can also generate ROS, which activates NF-κB signalling in the airway epithelium, leading to the secretion of the epithelial cytokines IL-1, IL-25, IL-33, GM-CSF, and TSLP, as well as other mediators. Subsequently a variety of cellular events are promoted and result in allergic sensitization to inhaled allergens [124,125]. O 3 [126], NO 2 [127], and cigarette smoke [128,129] induce epithelial cells to release ROS and RNS.…”

Section: Effect Of Air Pollutants On the Airway Epithelium And Respirmentioning

confidence: 99%

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

López-Rodríguez

Benedé

Barderas

et al. 2017

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

Airway epithelium is the cellular structure with the greatest surface exposed to a plethora of environmental airborne substances, including microorganisms, respiratory viruses, air pollutants, and allergens. In addition to being a protective physical barrier at the air-liquid interface, the airway epithelium acts as an effective chemical and immunological barrier that plays a crucial role in orchestrating the immune response in the lungs, by supporting the activation, recruitment, and mobilization of immune cells. Airway epithelium dysfunction has been clearly associated with various airway inflammatory diseases, such as allergic asthma. Although it is not fully understood why a person develops respiratory allergy, a growing body of evidence shows that the nature of the host's immune response is strongly determined by the state of the airway epithelium at the time of contact with the inhaled allergen. Our review highlights the physiological state of airway epithelium as a key element in the development of allergy and, particularly, in exacerbation of asthma. We review the role of physiological oxidants as signaling molecules in lung biology and allergic diseases and examine how high exposure to air pollutants (eg, cigarette smoke and diesel particles) can contribute to the increased incidence of respiratory allergy and exacerbation of the disease. Key words: Airway epithelium. Barrier dysfunction. Respiratory allergy. Redox biology. Air pollutants. ResumenEl epitelio pulmonar constituye la barrera celular más susceptible a la acción deletérea de la multitud de agentes que se encuentran en el ambiente, incluidos los alérgenos. Además de prevenir su acceso al organismo, la barrera epitelial de las vías respiratorias juega un papel inmunomodulador crucial, regulando de forma local la acción de las células del sistema inmune subyacentes. Una disfunción epitelial, provocada tanto directa como indirectamente por la acción de los aeroalérgenos, parece ser una de las causas principales de desregulación de la homeostasis pulmonar, causando una respuesta proinflamatoria descontrolada que cada vez más autores atribuyen al origen de las reacciones alérgicas. En esta revisión se quiere destacar el papel de la barrera epitelial pulmonar como regulador de la respuesta inmune en el contexto de la alergia. Las enfermedades crónicas que afectan a las vías respiratorias, tales como el asma alérgica, muestran frecuentemente una función epitelial defectuosa, apoyando así la hipótesis antes mencionada que subyace al origen de la alergia. El impacto de otros contaminantes ambientales -como virus respiratorios, bacterias, humo del tabaco y partículas diésel-sobre la integridad epitelial, así como su influencia en la biología redox pulmonar relacionada con el desarrollo de la respuesta alérgica, también se abordarán en la presente revisión.

show abstract

Air pollution and allergic diseases

Cited by 62 publications

References 108 publications

Onset and remission of rhinitis among students in relation to the home and school environment—A cohort study from Northern China

Onset and remission of rhinitis among students in relation to the home and school environment—A cohort study from Northern China

Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

Airway Epithelium Plays a Leading Role in the Complex Framework Underlying Respiratory Allergy

Contact Info

Product

Resources

About