The role of TRPMLs in endolysosomal trafficking and function

Venkatachalam, Kartik; Wong, Ching On; Zhu, Michael X.

doi:10.1016/j.ceca.2014.10.008

Cited by 170 publications

(161 citation statements)

References 141 publications

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“…26) While mutants of TRPML display severe neurodegeneration and motor deficits associated with impairment of autophagic removal of damaged mitochondria, as well as accumulation of lysosome vesicles, 27) it is unclear how rapidly these effects would incapacitate an insect if TRPML were attacked chemically.…”

Section: Trpmlmentioning

confidence: 99%

Insect TRP channels as targets for insecticides and repellents

Salgado

2017

Journal of Pesticide Science

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This review provides a brief overview of ion channels, then focuses on TRP channels, describing the properties and functions of the seven TRP channel classes found in insects. Finally, recent work showing that a heteromeric channel composed of Nanchung and Inactive vanilloid TRP (TRPV) channel subunits is the target of the selective feeding blockers pymetrozine and pyrifluquinazon is described. The possible utility of other TRP channels as targets of insecticides and repellents is also considered. © Pesticide Science Society of Japan

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Section: Trpmlmentioning

confidence: 99%

Insect TRP channels as targets for insecticides and repellents

Salgado

2017

Journal of Pesticide Science

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“…Transient receptor potential mucolipin 1 (TRPML1) (10,(13)(14)(15) belongs to the large family of transient receptor potential ion channels that permeates Ca 2ϩ , Na ϩ , and other cations (10,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Mutations in TRPML1 gene lead to mucolipidosis type IV (ML4) disease, which is characterized with defects in membrane trafficking in the late endocytic pathway (10,29), enlarged lysosomes (10,29), and impaired lysosome biogenesis (30 -32).…”

mentioning

confidence: 99%

The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin

Cao¹,

Yang²,

Zhong

et al. 2017

Journal of Biological Chemistry

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Edited by Roger J. Colbran Intracellular lysosomal membrane trafficking, including fusion and fission, is crucial for cellular homeostasis and normal cell function. Both fusion and fission of lysosomal membrane are accompanied by lysosomal Ca 2؉ release. We recently have demonstrated that the lysosomal Ca 2؉ release channel P2X4 regulates lysosome fusion through a calmodulin (CaM)-dependent mechanism. However, the molecular mechanism underlying lysosome fission remains uncertain. In this study, we report that enlarged lysosomes/vacuoles induced by either vacuolin-1 or P2X4 activation are suppressed by up-regulating the lysosomal Ca 2؉ release channel transient receptor potential mucolipin 1 (TRPML1) but not the lysosomal Na ؉ release channel two-pore channel 2 (TPC2). Activation of TRPML1 facilitated the recovery of enlarged lysosomes/vacuoles. Moreover, the effects of TRPML1 on lysosome/vacuole size regulation were eliminated by Ca 2؉ chelation, suggesting a requirement for TRPML1-mediated Ca 2؉ release. We further demonstrate that the prototypical Ca 2؉ sensor CaM is required for the regulation of lysosome/vacuole size by TRPML1, suggesting that TRPML1 may promote lysosome fission by activating CaM. Given that lysosome fission is implicated in both lysosome biogenesis and reformation, our findings suggest that TRPML1 may function as a key lysosomal Ca 2؉ channel controlling both lysosome biogenesis and reformation.

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“…NAADP as a potent Ca 2+ mobilizing messenger, which targets the TRPMLs or TPCs and triggers Ca 2+ release from the endolysosomal stores [19]. As we known, the members of the TRPML constitute a family of evolutionarily conserved cation channels that play crucial roles in endolysosomal vesicles [20] [49]. TRPMLs localize to endolysosomes and facilitate Ca 2+ -dependent fusion between autophagosomes and lysosomes resulting in lysosomal degradation of autophagic material [20].…”

Section: The Negative Regulation Of Cd38 In Autophagymentioning

confidence: 99%

“…As we known, the members of the TRPML constitute a family of evolutionarily conserved cation channels that play crucial roles in endolysosomal vesicles [20] [49]. TRPMLs localize to endolysosomes and facilitate Ca 2+ -dependent fusion between autophagosomes and lysosomes resulting in lysosomal degradation of autophagic material [20]. It is known that TPCs have recently emerging as the targets for NAADP, which are crucial for appropriate basal and induced autophagic flux in cardiomyocytes [50].…”

Section: The Negative Regulation Of Cd38 In Autophagymentioning

confidence: 99%

Dual Roles of CD38 in Autophagy

Wang¹,

Song²,

Wu³

et al. 2017

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CD38 is a versatile, ubiquitously expressed protein that was identified as a multifunctional enzyme. Recently, cumulating evidence has suggested that CD38 is involved in autophagy, which is an evolutionarily conserved lysosomal degradation and recycling system. Acting as a enzyme, CD38 utilizes nicotinamide adenine dinucleotide phosphate (NADP) to synthesize nicotinic acid adenine dinucleotide phosphate (NAADP), which acts as a key messenger for Ca 2+ -mobilizing in lysosome by targeting two-pore channels (TPCs) or transient receptor potential mucolipins (TRPMLs). Multiple studies have indicated that CD38 is involved in autophagy by modulating intracellular Ca 2+ signaling. However, the control of autophagy by CD38 signaling is the subject of two contrary views. The autophagosomes trafficking and fusion with lysosomes to form autolysosomes are crucial steps in autophagy. On the one hand, the available evidence indicates that lysosome trafficking and fusion to autophagosomes is positively modulated by CD38. On the other hand, overexpression of TPC2, which is positively modulated by CD38, was shown to promote the accumulation of autophagosomes, thus suppress autophagy. This review will reveal the interesting contrary dual roles of CD38 in autophagy, and critical insight into the molecular mechanisms of CD38 in autophagy regulation.

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The role of TRPMLs in endolysosomal trafficking and function

Cited by 170 publications

References 141 publications

Insect TRP channels as targets for insecticides and repellents

Insect TRP channels as targets for insecticides and repellents

The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin

Dual Roles of CD38 in Autophagy

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