Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks׳ gestation in nulliparous women who subsequently develop preeclampsia

Mistry, Hiten D.; Gill, Carolyn; Kurlak, Lesia O.; Seed, Paul; Hesketh, John E.; Méplan, Catherine; Schomburg, Lutz; Chappell, Lucy C; Morgan, Linda; Poston, Lucilla

doi:10.1016/j.freeradbiomed.2014.10.580

Cited by 60 publications

(55 citation statements)

References 57 publications

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“…A further two studies reported circulating zinc to be lower in women who developed severe PE (blood pressure BP ≥ 160/110) compared to women whose pregnancies remained uncomplicated [73,74]. The remaining eight studies, whose sample sizes ranged from 10–271 women with PE/GH and 10–2038 women with an uncomplicated pregnancy, reported no difference in maternal zinc status between women with a hypertensive disorder of pregnancy and those without [38,47,54,75,76,77,78,79]. …”

Section: Resultsmentioning

confidence: 99%

Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

et al. 2016

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Adequate zinc stores in the body are extremely important during periods of accelerated growth. However, zinc deficiency is common in developing countries and low maternal circulating zinc concentrations have previously been associated with pregnancy complications. We reviewed current literature assessing circulating zinc and dietary zinc intake during pregnancy and the associations with preeclampsia (PE); spontaneous preterm birth (sPTB); low birthweight (LBW); and gestational diabetes (GDM). Searches of MEDLINE; CINAHL and Scopus databases identified 639 articles and 64 studies were reviewed. In 10 out of 16 studies a difference was reported with respect to circulating zinc between women who gave birth to a LBW infant (≤2500 g) and those who gave birth to an infant of adequate weight (>2500 g), particularly in populations where inadequate zinc intake is prevalent. In 16 of our 33 studies an association was found between hypertensive disorders of pregnancy and circulating zinc; particularly in women with severe PE (blood pressure ≥160/110 mmHg). No association between maternal zinc status and sPTB or GDM was seen; however; direct comparisons between the studies was difficult. Furthermore; only a small number of studies were based on women from populations where there is a high risk of zinc deficiency. Therefore; the link between maternal zinc status and pregnancy success in these populations cannot be established. Future studies should focus on those vulnerable to zinc deficiency and include dietary zinc intake as a measure of zinc status.

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Section: Resultsmentioning

confidence: 99%

Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

et al. 2016

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“…As most of the Elisa plate analyzers do not have filters to measure the absorbance at 593 nm, the nearest wavelength of 560 nm was chosen in this study. Thus, the method became applicable and for the commercial Elisa kits 560 nm absorbance was determined as well [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…Mistry et al [10] reported that with a commercial kit, the workable assay range was 31.25-1000 µmol/L and the inter-and intra-assay coefficients of variation were 9.3 and 4.3%, respectively. Our inter-and intraassay coefficients of variation were higher [10].…”

Section: Discussionmentioning

confidence: 99%

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Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates

Üstündağ¹,

Huysal²,

Kahvecioğlu³

et al. 2016

Eur Res J

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Objectives. The total antioxidant capacity (TAC) of a sample can be measured with a ferric reducing antioxidant power (FRAP) assay. There are commercially available kits for FRAP assays, however they are more expensive than in-house kits. We aimed to evaluate a FRAP direct measurement method under our laboratory conditions using a microplate reader and establish reference values to use in future research projects. Methods. An inhouse microplate adaptation of the FRAP method was evaluated. Reference values of FRAP were established for one hundred and twenty subjects aged between 25-55 years. FRAP levels were estimated in 30 serum samples with high glucose concentration, 44 hyperbiluribinemic neonatals and 16 patients receiving renal replacement therapy (RRT). Results. The mean FRAP level was 890±235 µmol/L. The median TAC level was 904 µmol/L. This method was found to be linear up to at least 2000 µmol/L. The intra-and inter-assay coefficients of variation were 2.7-6.7% and 5.3-10.1%, respectively. The mean FRAP level was lower than normal in diabetes and RRT patients and higher in hyperbiluribinemic neonatals (687±209 µmol/L, 609±250 µmol/L and 945±187 µmol/L, respectively). Conclusions. Our reference values give comparable results with the literature. This method is simple, reliable, and inexpensive. It could be used for studies of oxidative stressrelated diseases.Eur Res J 2016;2(2):126-131

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“…Finally, the mean age (year) for the women used in our study is published in Table 1 of the manuscript [3].…”

Section: Sirmentioning

confidence: 99%

Letter Regarding: Selenium and Preeclampsia: A Systemic Review and Meta-Analysis

Mistry

Pipkin

Kurlak

2016

Biol Trace Elem Res

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Sir,We are surprised to see several serious errors have crept into systematic review and meta-analysis on selenium and preeclampsia (PE) by Xu et al., (October 2015) [1], detailed below.First, we believe they have misinterpreted our data published in Hypertension [2]. The authors state that 'Se in the umbilical cord was significantly lower in the PE group than in the control while not in serum in two studies [25, 26]' where reference 26 is our manuscript. But our data show that the umbilical venous serum selenium concentrations were lower in the PE group: 'Selenium concentrations were significantly reduced in umbilical venous samples in preeclampsia by comparison with samples from babies of normotensive mothers (P < 0.0001)'. Secondly, the numbers quoted in the manuscript Table 1 and Figure 2 are incorrect and should be (mean ± SD) normotensive 42.1 ± 11.8; PE 29.0 ± 9.9 μg/L; these have been written the wrong way around and thus significantly affects the results of the authors analyses, particularly in relation to the data presented in Figure 2.In addition to the above, in both our manuscripts [2; 3], we have clearly stated the PE criteria, which are detailed in the methods. Finally, the mean age (year) for the women used in our study is published in Table 1 of the manuscript [3].We would be grateful of some acknowledgement to the original manuscript that the error will affect the systematic review and meta-analysis results. On finding these errors, we are concerned that similar errors may have occurred to other manuscripts referenced in this systematic review/metaanalysis.

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Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks׳ gestation in nulliparous women who subsequently develop preeclampsia

Cited by 60 publications

References 57 publications

Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates

Letter Regarding: Selenium and Preeclampsia: A Systemic Review and Meta-Analysis

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