Letter Regarding: Selenium and Preeclampsia: A Systemic Review and Meta-Analysis

Abstract

Sir,We are surprised to see several serious errors have crept into systematic review and meta-analysis on selenium and preeclampsia (PE) by Xu et al., (October 2015) [1], detailed below.First, we believe they have misinterpreted our data published in Hypertension [2]. The authors state that 'Se in the umbilical cord was significantly lower in the PE group than in the control while not in serum in two studies [25, 26]' where reference 26 is our manuscript. But our data show that the umbilical venous serum selenium concentrations were lower in the PE group: 'Selenium concentrations were significantly reduced in umbilical venous samples in preeclampsia by comparison with samples from babies of normotensive mothers (P < 0.0001)'. Secondly, the numbers quoted in the manuscript Table 1 and Figure 2 are incorrect and should be (mean ± SD) normotensive 42.1 ± 11.8; PE 29.0 ± 9.9 μg/L; these have been written the wrong way around and thus significantly affects the results of the authors analyses, particularly in relation to the data presented in Figure 2.In addition to the above, in both our manuscripts [2; 3], we have clearly stated the PE criteria, which are detailed in the methods. Finally, the mean age (year) for the women used in our study is published in Table 1 of the manuscript [3].We would be grateful of some acknowledgement to the original manuscript that the error will affect the systematic review and meta-analysis results. On finding these errors, we are concerned that similar errors may have occurred to other manuscripts referenced in this systematic review/metaanalysis.

Dietary factors that affect the risk of pre-eclampsia

“…It showed an inverse association of blood selenium level with the risk of pre-eclampsia and that supplementation with selenium significantly reduces the incidence of pre-eclampsia. However, this study has been criticised for its methodology 117. A later study (2021) nicely summarised the associations between selenium status or selenium supplementation and pregnancy-induced hypertensive disorders 118.…”