Significance of association of HLA-C and HLA-E with psoriatic arthritis

Sokolik, Renata; Gębura, Katarzyna; Iwaszko, Milena; Świerkot, Jerzy; Korman, Lucyna; Wiland, Piotr; Bogunia‐Kubik, Katarzyna

doi:10.1016/j.humimm.2014.10.005

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…However, the relationship between HLA‐Cw6 and PsA severity is unclear. One study reported that patients with PsA with more severe disease were more often characterized by HLA‐Cw6 genotype and were more likely to have polyarthritis . However, several studies reported that HLA‐Cw6 ‐positive patients with PsA tend to have reduced penetrance and milder musculoskeletal symptoms …”

Section: Association With Psoriatic Arthritismentioning

confidence: 99%

HLA-Cw6 and psoriasis

Chen

Tsai

2018

British Journal of Dermatology

127

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Psoriasis is a multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. It is repeatedly observed to affect disease course, phenotypic features, severity, comorbidities and treatment outcomes. To the best of our knowledge, the roles of HLA-Cw6 in psoriasis have not yet been thoroughly reviewed. The worldwide frequency of the HLA-Cw6 allele varies greatly, with it being generally higher in white people than in Asians. The allele is associated with type I early-onset psoriasis. Stress, obesity and streptococcal pharyngitis are commonly observed in HLA-Cw6-positive patients. Phenotypically, HLA-Cw6 has been found to be associated with guttate psoriasis. In addition, patients carrying the allele are more likely to have arm, leg and trunk involvement, and the Koebner phenomenon. Patients with psoriatic arthritis with HLA-Cw6 more often have early onset and tend to show cutaneous symptoms before musculoskeletal symptoms. HLA-Cw6-positive patients have been shown in several studies to be more responsive to methotrexate and ustekinumab. However, this difference in ustekinumab efficacy was only moderate in a post-hoc analysis of a pivotal phase III study. HLA-Cw6 positivity also tends to be less frequent in high-need patients who fail conventional therapy. Small studies have also investigated the role of HLA-Cw6 in remission of psoriasis during pregnancy, and with the comorbidities of photosensitivity and atherosclerosis. Given the diverse nature of psoriasis pathogenesis, as well as the difference of HLA-Cw6 positivity in different ethnic groups, more studies are needed to confirm the role of HLA-Cw6 in psoriasis.

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Section: Association With Psoriatic Arthritismentioning

confidence: 99%

HLA-Cw6 and psoriasis

Chen

Tsai

2018

British Journal of Dermatology

127

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“…We report the first GoShare‐consented subcohort of the Tayside MTX treatment cohort, and detail the efficacy and safety outcomes for MTX treatment based on human leucocyte antigen (HLA)‐Cw6 status, which can identify two established genetic psoriasis subgroups and is also genetically associated with psoriatic arthritis (PsA) …”

mentioning

confidence: 99%

HLA-Cw6-positive patients with psoriasis show improved response to methotrexate treatment

et al. 2017

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It is well documented that patients with human leucocyte antigen (HLA)-Cw6+ (type 1) psoriasis have increased severity and reduced age of onset of psoriasis. However, not much is known about any differential response of this genetic subgroup to various treatments. We set out to determine if there was any genetic association of the HLA-Cw6 allele with the first-line systemic treatment commonly used in psoriasis, methotrexate. A cohort of patients from Tayside in Scotland was recruited through a novel generic consenting process (GoShare); they were extensively phenotyped and analysed for an association of their HLA-Cw6 genotype status with treatment outcomes. HLA-Cw6+ patients showed notably improved response to methotrexate (P = 0.05), and further analysis demonstrated an even greater response in a subcohort of the HLA-Cw6+ patients, who did not have concomitant psoriatic arthritis (P = 0.01). HLA-Cw6+ patients also exhibited fewer treatment-limiting adverse events. In addition to these findings, the methodology and primary clinical outcome phenotype, which we validate here, will greatly facilitate replication of the present results in independent cohorts.

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“… 1 Several articles demonstrated a correlation between HLA-C and PsA. The most intriguing allele, HLA-C*06, has already been described in a number of populations with susceptibility to PsA, such as native populations of the Czech Republic, 20 Spain, 21 - 22 Great Britain, 9 Poland, 23 Romania, 24 Sweden 25 and Newfoundland. 19 Furthermore, genome-wide association studies have confirmed that the HLA-C region is involved in susceptibility to PsA in populations of European and Middle Eastern descent.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 153 studies were identified after initial review using the search strategies previously described, and 24 articles were retained for meta-analysis ( Figure 1). [7][8][9][10][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] After accessing the full-text of the eligible stud-ies, one study 19 was split into two studies because it contained data for two different subpopulations. Thus, 25 studies were included ( Table 1).…”

Section: Included Studiesmentioning

confidence: 99%

Associations between human leukocyte antigen C locus polymorphism and psoriatic arthritis in populations of European and Middle Eastern descent: a meta-analysis

Shao¹,

Wang²,

Zhou³

et al. 2020

Ann Saudi Med

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BACKGROUND: Gene-disease association between human leukocyte antigen (HLA)-C locus polymorphism and psoriatic arthritis (PsA) remains controversial. OBJECTIVE: Evaluate the relationship between HLA-C locus polymorphism and PsA in populations of European and Middle Eastern descent. SEARCH METHODS: PubMed, PMC, Elsevier and Google Scholar databases from 1980 to January 2020. The search was limited to articles in English. SELECTION CRITERIA: Case-control studies (with unrelated participants) that had allele/genotype data on the association between HLA-C locus polymorphism and PsA susceptibility. DATA COLLECTION AND ANALYSIS: Two investigators searched independently in searching the literature. Disagreements were resolved by discussion and consultation with a third researcher. The Q-Genie tool was used to assess the quality of articles. RESULTS: Twenty-five studies met the inclusion criteria. At the allelic level, three alleles were associated with an increased risk of PsA and five were associated with a reduced risk. At the phenotypic level, four alleles were associated with increased risk of PsA and three were associated with a reduced risk. At both the allelic and phenotypic levels, the results revealed that HLA-C*04 played a protective role in PsA (The pooled odds ratio [OR] is 0.66 for allelic level and 0.63 for phenotypic level), while HLA-C*02, *06 and *12 increased the risk of suffering from PsA (The pooled ORs of C*02, *06 and *12 are 2.21, 2.63 and 1.49 for allelic level, and 1.79, 2.96 and 2.25 for phenotypic level, respectively). CONCLUSION: The pooled results showed a significant association between PsA and the HLA-C gene in populations of European and Middle Eastern descent. At both the allelic and phenotypic levels, the HLA-C*02, *06 and *12 may contribute to susceptibility to PsA, while HLA-C*04 may confer a protective role against PsA. REGISTRATION: Not registered. CONFLICT OF INTEREST: None.

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Significance of association of HLA-C and HLA-E with psoriatic arthritis

Cited by 14 publications

References 23 publications

HLA-Cw6 and psoriasis

HLA-Cw6 and psoriasis

HLA-Cw6-positive patients with psoriasis show improved response to methotrexate treatment

Associations between human leukocyte antigen C locus polymorphism and psoriatic arthritis in populations of European and Middle Eastern descent: a meta-analysis

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