Pediatric Lipid Management

Zachariah, Justin P.; Johnson, Philip

doi:10.1016/j.ecl.2014.08.004

Cited by 14 publications

(6 citation statements)

References 72 publications

(60 reference statements)

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“…According to the American Academy of Pediatrics (AAP), National Heart, Lung and Blood Institute (NHLBI) and other recommendations, children with obesity or familial aggregation of hyperlipidemia should have their lipid concentrations monitored regularly [28,29]. However, in Poland such tests are not conducted regularly or financed by the public payer (tests are included in the PHC package, but there are no guidelines requiring such tests to be performed in children).…”

Section: Discussionmentioning

confidence: 99%

Lipid disorders in children living with overweight and obesity- large cohort study from Poland

Brzeziński

Metelska²,

Myśliwiec

et al. 2020

Lipids Health Dis

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Background: While in the general paediatric population the presence of abnormal lipid values is estimated at 8-20%, depending on the population, accepted norms and age, it was shown that in the population of lean children the prevalence of dyslipidemia is lower than in obese children, in whom it ranges from 20 to over 40%. Until now, however, no results of similar studies on a large sample of children form a Central or Eastern European country have been published. The aim of this study was to evaluate the prevalence of lipid disorders in overweight and obese children and adolescents participating in an integrated weight reduction programme. Methods: According to the "6-10-14 for Health" programme implementation schedule, the programme accepted patients living in Gdańsk, aged 6, 9-11 and 14 years old, with BMI above the 85th percentile for age and sex, according to the Polish percentile charts. During the first visit, each of the participants underwent basic anthropometric examinations-body weight, body height, waist and hip circumference, blood pressure and body composition by bioelectrical impedance were measured. Blood samples were taken to assess lipid, glucose and insulin levels as well as alanine transaminase (ALT) and thyroid stimulating hormone (TSH) activity. Results: 1948 patients underwent full anthropomethric and blood work measurements. At least one of the lipid disorders occurred in 38.23% of girls and 40.51% of boys with overweight and obesity. The most common lipid disorderswere decreased high-density lipoprotein cholesterol (HDL-C) levels (present in 20.55% of the girls and 23.79% of the boys) and elevated low-density lipoprotein cholesterol (LDL-C) (present in 15.31% of the girls and 14.25% of the boys). There was no strong association between lipid disorders and age, sex, birth weight, gestational age at birth or body composition. Conclusions: Such a frequent occurrence of lipid disorders in the population of children and adolescents should be an important warning signal both at the individual and population level. Not only effective screening methods for overweight and obese children should be implemented from an early age but also therapeutic measures are required.

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Section: Discussionmentioning

confidence: 99%

Lipid disorders in children living with overweight and obesity- large cohort study from Poland

Brzeziński

Metelska²,

Myśliwiec

et al. 2020

Lipids Health Dis

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“…Persistent dyslipidemia in children has been linked with cardiovascular disease (CVD) risks [31,32], which could potentially jeopardize the achievements in reducing HIV associated child mortality and morbidity [33]. With regular screening integrated in the HIV care and treatment, adopting recommended life style modifications and lipid lowering treatment in a small proportion would help to decrease the future risks of CVD risks [34].…”

Section: Discussionmentioning

confidence: 99%

HIV and cART-Associated Dyslipidemia Among HIV-Infected Children

Tadesse

Foster

Chala

et al. 2019

JCM

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Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children. Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Demographic and clinical data, lipid profile, cART type, adherence to and duration on cART were recorded. Total, low density (LDLc) and high density (HDLc) cholesterol values >200 mg/dL, >130 mg/dL, <40 mg/dL, respectively; and/or, triglyceride values >150 mg/dL defined cases of dyslipidemia. Prevalence and predictors of dyslipidemia were compared between the two groups. Results: prevalence of dyslipidemia was significantly higher among cART experienced (70.2%) than treatment naïve (58.1%) children (p = 0.03). Prevalence of low HDLc (40.2% versus 23.4%, p = 0.006) and hypertriglyceridemia (47.2% versus 35.8%, p = 0.02) was higher among cART experienced than naïve children. There was no difference in total hypercholesterolemia and high LDLc levels. Nutrition state was associated with dyslipidemia among cART naïve children (p = 0.01). Conclusion: high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia was observed among treatment experienced HIV-infected children. The findings underscore the need for regular follow up of children on cART for lipid abnormalities.

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“…Unlike the Brazilian Dyslipidemia Directive (DBD) Update, universal lipid screening over two years of age as compared to that of children with risk factors 3 was recommended, based on other studies, by Zachariah and Johnson 7 for having a greater diagnostic sensitivity by 30% to 60%. In Brazil, there are few population studies involving dyslipidemias in childhood and adolescence.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Lipid Profiles of Children and Youth from Basic Health Units in Campinas, SP, Brazil: A Cross‑Sectional Laboratory Study

Gomes¹,

Zago²,

Faria³

2019

Arquivos Brasileiros De Cardiologia

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Background: Among dyslipidemias, hypercholesterolemia is considered the main risk factor for cardiovascular diseases in adults. In childhood and adolescence, elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are positively associated with atherosclerosis markers, however, systematic screening for dyslipidemias in these groups is a controversial topic. Objective: To characterize the frequencies, types and severity of dyslipidemias in children and adolescents attended at the Basic Health Units managed by SUS in Campinas/SP. Methods: After an agreement with the Municipal Health Department of Campinas, consecutive results of serum lipid profiles (n = 312,650) of individuals of both sexes (n = 62,530) aged between 1 day old and 19 years were obtained, from 2008 to 2015. Age groups and dyslipidemias were classified according to recommendations in the literature. The statistical significance level adopted was the probability value (p) of 0.05 or less. Results: The observed frequencies of increased TC, triglycerides (TG), LDL-C and non-HDL-C (NHDL-C) were 33%, 40%, 29% and 13% respectively, and of reduced high-density lipoprotein cholesterol (HDL-C) the frequency was 39%. The frequencies, in general, were greater in females and in the southwest and south regions of the city, whose populations are more vulnerable from the socioeconomic point of view; on the other hand, in children and adolescents, the frequencies of TG and HDL-C prevailed, respectively. Conclusions: The high frequency and regionalization of dyslipidemias in children and adolescents indicate the need for specific actions in the handling and treatment of such diseases by the public health system of Campinas.

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Pediatric Lipid Management

Cited by 14 publications

References 72 publications

Lipid disorders in children living with overweight and obesity- large cohort study from Poland

Lipid disorders in children living with overweight and obesity- large cohort study from Poland

HIV and cART-Associated Dyslipidemia Among HIV-Infected Children

Evaluation of Lipid Profiles of Children and Youth from Basic Health Units in Campinas, SP, Brazil: A Cross‑Sectional Laboratory Study

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