MicroRNA Signatures as Biomarkers and Therapeutic Target for CNS Embryonal Tumors: The Pros and the Cons

Shalaby, Tarek; Fiaschetti, Giulio; Baumgärtner, Martin; Grotzer, Michael A.

doi:10.3390/ijms151121554

Cited by 31 publications

(26 citation statements)

References 189 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti‐TNF‐α therapy has a profound effect on the serum level of circulating miRNAs in psoriasis; however, these are not related to disease severity . The therapeutic application of miRNAs involves two approaches: miRNA antagonists and miRNA mimics/replacement. miRNA antagonists inhibit endogenous miRNAs.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis

Mogaddam

Ardabili

Shafaeei

et al. 2017

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis

Mogaddam

Ardabili

Shafaeei

et al. 2017

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…The role of miRNAs includes directing and regulating the gene expression of the CSCs. Aberrant expression of miRNA is commonly observed in many types of tumors [31, 32]. One such miRNA, let-7, was found to help control the self-renewal and tumorigenicity in breast, lung, and many other types of cancers [33, 34].…”

Section: Which Species Of Mirna In Cscs Respond To Tissue Mechanics?mentioning

confidence: 99%

Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a ″Watch-and-Wait″� Approach to Cancer

Luo

et al. 2017

CSCR

View full text Add to dashboard Cite

Targeting the tumor microenvironment (TME) through which cancer stem cells (CSCs) crosstalk for cancer initiation and progression, may open up new treatments different from those centered on the original hallmarks of cancer genetics thereby implying a new approach for suppression of TME-driven activation of CSCs. Cancer is dynamic, heterogeneous, evolving with the TME and can be influenced by tissue-specific elasticity. One of the mediators and modulators of the crosstalk between CSCs and mechanical forces is miRNA, which can be developmentally regulated, in a tissue- and cell-specific manner. Here, based on our previous data, we provide a framework through which such gene expression changes in response to external mechanical forces can be understood during cancer progression. Recognizing the ways mechanical forces regulate and affect intracellular signals with applications in cancer stem cell biology. Such TME-targeted pathways shed new light on strategies for attacking cancer stem cells with fewer side effects than traditional gene-based treatments for cancer, requiring a “watch-and-wait” approach. We attempt to address both normal brain microenvironment and tumor microenvironment as both works together, intertwining in pathology and physiology – a balance that needs to be maintained for the “watch-and-wait” approach to cancer. Thus, this review connected the subjects of tissue elasticity, tumor microenvironment, epigenetic of miRNAs, and stem-cell biology that are very relevant in cancer research and therapy. It attempts to unify apparently separate entities in a complex biological web, network, and system in a realistic and practical manner, i.e., to bridge basic research with clinical application.

show abstract

“…miRNAs have the ability to regulate the expression of multiple targets instead of a specific target such as small interfering RNA (siRNA) and specific proteins such as BMP . By being able to regulate multiple targets that are involved in a specific signaling cascade with just one molecule, the delivery of miRNA can be advantageous compared to other biomolecules or drug …”

Section: Introductionmentioning

confidence: 99%

The Application of microRNAs in Biomaterial Scaffold‐Based Therapies for Bone Tissue Engineering

Arriaga

Ding

Gutierrez

et al. 2019

Biotechnology Journal

View full text Add to dashboard Cite

In recent years, the application of microRNAs (miRNAs) or anti-microRNAs (anti-miRNAs) that can induce expression of the runt-related transcription factor 2 (RUNX2), a master regulator of osteogenesis, has been investigated as a promising alternative bone tissue engineering strategy. In this review, biomaterial scaffold-based applications that have been used to deliver cells expressing miRNAs or anti-miRNAs that induce expression of RUNX2 for bone tissue engineering are discussed. An overview of the components of the scaffold-based therapies including the miRNAs/anti-miRNAs, cell types, gene delivery vectors, and scaffolds that have been applied are provided. To date, there have been nine miRNAs/anti-miRNAs (i.e., miRNA-26a, anti-miRNA-31, anti-miRNA-34a, miRNA-135, anti-miRNA-138, anti-miRNA-146a, miRNA-148b, anti-miRNA-221, and anti-miRNA-335) that have been incorporated into scaffold-based bone tissue engineering applications and investigated in an in vivo bone critical-sized defect model. For all of the biomaterial scaffold-based miRNA therapies that have been developed thus far, cells that are transfected or transduced with the miRNA/anti-miRNA are loaded into the scaffolds and implanted at the site of interest instead of locally delivering the miRNA/anti-miRNAs directly from the scaffolds. Thus, future work may focus on developing biomaterial scaffolds to deliver miRNAs or anti-miRNAs into cells in vivo.

show abstract

MicroRNA Signatures as Biomarkers and Therapeutic Target for CNS Embryonal Tumors: The Pros and the Cons

Cited by 31 publications

References 189 publications

Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis

Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis

Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a ″Watch-and-Wait″� Approach to Cancer

The Application of microRNAs in Biomaterial Scaffold‐Based Therapies for Bone Tissue Engineering

Contact Info

Product

Resources

About