Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (<scp>DGCR</scp>8), and Dicer <scp>mRNA</scp>s in the pathogenesis of psoriasis

Mogaddam, Majid Rostami; Ardabili, Nastaran Safavi; Shafaeei, Yousef; Maleki, Nasrollah; Jafari, Naser; Jafari, Alireza

doi:10.1111/jocd.12336

Cited by 8 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Psoriasis, a papulosquamous skin disease, is a common immune-mediated disorder [ 106 ]. Specifically, psoriasis is a chronic skin inflammatory disease characterized by a vicious circle of chronic inflammation caused by the interaction between keratinocytes and immune cells [ 107 , 108 ].…”

Section: Dicer In Human Diseasesmentioning

confidence: 99%

“…The pathogenesis of psoriasis involves both innate and acquired immunity, as well as genomic background, keratinocytes and environmental factors [ 109 , 110 ]. Transcripts of approximately 1340 genes were found to be deregulated, with potential implications for this disorder [ 106 , 107 , 111 ]. In a recent study, the expression level of Dicer was also deregulated in skin biopsies, demonstrating higher levels of transcription in psoriasis skin tissue than in healthy individuals [ 106 ] ( Figure 6 ).…”

Section: Dicer In Human Diseasesmentioning

confidence: 99%

“…Transcripts of approximately 1340 genes were found to be deregulated, with potential implications for this disorder [ 106 , 107 , 111 ]. In a recent study, the expression level of Dicer was also deregulated in skin biopsies, demonstrating higher levels of transcription in psoriasis skin tissue than in healthy individuals [ 106 ] ( Figure 6 ). Dicer appears to have a distinct role in psoriasis, and the aberrant expression of this molecule could be related to disease progression.…”

Section: Dicer In Human Diseasesmentioning

confidence: 99%

“…This may be due to the subsequent deregulation of gene expression and small RNAs, as several miRNAs have been found to be deregulated in psoriasis skin lesions [ 112 ]. miRNAs are involved in skin development, epidermal differentiation and hair follicle development [ 113 , 114 ], whereas individual miRNAs control the levels of inflammatory proteins in the skin of patients with psoriasis [ 106 ]. Among others, miR-203 is a typical example of a tissue-specific miRNA, which has a skin-restricted expression profile and acts as a tumor suppressor regulating the differentiation and proliferation of keratinocytes.…”

Section: Dicer In Human Diseasesmentioning

confidence: 99%

See 3 more Smart Citations

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies

Theotoki

Pantazopoulou

Georgiou

et al. 2020

IJMS

View full text Add to dashboard Cite

Gene expression dictates fundamental cellular processes and its de-regulation leads to pathological conditions. A key contributor to the fine-tuning of gene expression is Dicer, an RNA-binding protein (RBPs) that forms complexes and affects transcription by acting at the post-transcriptional level via the targeting of mRNAs by Dicer-produced small non-coding RNAs. This review aims to present the contribution of Dicer protein in a wide spectrum of human pathological conditions, including cancer, neurological, autoimmune, reproductive and cardiovascular diseases, as well as viral infections. Germline mutations of Dicer have been linked to Dicer1 syndrome, a rare genetic disorder that predisposes to the development of both benign and malignant tumors, but the exact correlation of Dicer protein expression within the different cancer types is unclear, and there are contradictions in the data. Downregulation of Dicer is related to Geographic atrophy (GA), a severe eye-disease that is a leading cause of blindness in industrialized countries, as well as to psychiatric and neurological diseases such as depression and Parkinson’s disease, respectively. Both loss and upregulation of Dicer protein expression is implicated in severe autoimmune disorders, including psoriasis, ankylosing spondylitis, rheumatoid arthritis, multiple sclerosis and autoimmune thyroid diseases. Loss of Dicer contributes to cardiovascular diseases and causes defective germ cell differentiation and reproductive system abnormalities in both sexes. Dicer can also act as a strong antiviral with a crucial role in RNA-based antiviral immunity. In conclusion, Dicer is an essential enzyme for the maintenance of physiology due to its pivotal role in several cellular processes, and its loss or aberrant expression contributes to the development of severe human diseases. Further exploitation is required for the development of novel, more effective Dicer-based diagnostic and therapeutic strategies, with the goal of new clinical benefits and better quality of life for patients.

show abstract

Section: Dicer In Human Diseasesmentioning

confidence: 99%

Section: Dicer In Human Diseasesmentioning

confidence: 99%

Section: Dicer In Human Diseasesmentioning

confidence: 99%

Section: Dicer In Human Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies

Theotoki

Pantazopoulou

Georgiou

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Next, the hairpin-shaped pre-miRNA is cut by cytoplasmic RNase III Dicer/TAR-RNA binding protein (TRBP) complex, which removes the hairpin loop and generates ⁓22 nt of unstable mature miRNA duplex [20,21]. A single strand of the miRNA duplex is incorporated into a 200-500 kD of ribonucleoprotein effector complex known as the RNA-induced silencing complex (RISC).…”

Section: Introductionmentioning

confidence: 99%

Downregulation of Drosha, Dicer, and DGCR8 mRNAs in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

et al. 2018

View full text Add to dashboard Cite

Dicer and Drosha expression in patients with nephrotic syndrome

et al. 2020

View full text Add to dashboard Cite

Podocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria. Some in vivo studies in Dicer/Drosha knockout mice indicate the importance of Dicer, Drosha, and microRNAs (miRNAs) in the pathogenesis of NS. In the present study, the expression levels of Dicer and Drosha along with miR‐30 family, miR‐186, miR‐193, and miR‐217 were evaluated in peripheral blood mononuclear cell samples of patients with NS (N = 60) using real‐time PCR. Dicer expression level in NS patients was significantly upregulated when compared to healthy controls (p = .008). No significant change was observed in the Drosha expression level in the NS group. Upregulated levels of the studied microRNAs were observed in NS group in comparison to controls, the miR‐30c‐5p (p = .005) and miR‐193‐3p (p = .041) were statistically significant. In conclusion, dysregulation in expression level of Dicer and Drosha and consequently, alteration in miRNA levels are involved in the pathophysiology of NS.

show abstract

Overexpression of Drosha, DiGeorge syndrome critical region gene 8 (DGCR8), and Dicer mRNAs in the pathogenesis of psoriasis

Abstract: Our data demonstrate that upregulated expression of Drosha, DGCR8, and Dicer mRNAs may be involved in the pathogenesis of psoriasis.

Cited by 8 publications

References 28 publications

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies

Downregulation of Drosha, Dicer, and DGCR8 mRNAs in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

Dicer and Drosha expression in patients with nephrotic syndrome

Contact Info

Product

Resources

About