Coronary CT angiography-derived fractional flow reserve correlated with invasive fractional flow reserve measurements – initial experience with a novel physician-driven algorithm

Abstract

• CT-based FFR computation is a promising novel non-invasive application. • A novel prototype algorithm permits time-efficient point-of-care CT-based FFR assessment. • Initial results of the CT-based FFR prototype algorithm compare favourably with FFR.

Diagnostic value of quantitative stenosis predictors with coronary CT angiography compared to invasive fractional flow reserve

“…Although these results have been encouraging, CT-FFR has been limited by the need for additional time-consuming analysis on a parallel supercomputer. In the present study, a novel CT-FFR prototype algorithm was evaluated that overcomes this limitation by providing time-efficient and on-site analysis without data transfer [20,21].…”

“…CT-FFR computation was performed by using a software prototype (Siemens cFFR, Version 1.4; Siemens Healthcare) for analysis of CCTA datasets [20,21]. Experienced observers blinded to the initial CCTA and invasive FFR results corrected the luminal contour and centerline proposals provided by the software.…”

Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography

“…A novel in-house CT-FFR prototype algorithm was used to expand CT-FFR utilization that increases its applicability in clinical practice, demonstrating good diagnostic CT-FFR performance similar to previously studies (82).…”

Beyond Stenosis Detection

“…6). 74 Compared with myocardial perfusion techniques, FFR-CT requires neither dedicated acquisition nor the administration of stress agents, which makes it possible to apply this technique to any CCTA acquisition, regardless of the scanner generation, without any additional risk for the patients that may stem from higher radiation dose or drug administration.…”