Differences in micronucleus frequency and acrylamide adduct levels with hemoglobin between vegetarians and non-vegetarians

Kotova, Natalia; Frostne, Cecilia; Abramsson‐Zetterberg, Lilianne; Tareke, Eden; Bergman, Rolf; Haghdoost, Siamak; Paulsson, Birgit; Törnqvist, Margareta; Segerbäck, Dan; Jenssen, Dag; Grawé, Jan

doi:10.1007/s00394-014-0796-7

Cited by 24 publications

(14 citation statements)

References 40 publications

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“…The mechanism by which BMI may influence acrylamide metabolism is still unclear, but similar to the present study, other studies have observed that BMI was positively associated with the ratio HbGA/HbAA, and negatively associated with HbAA [14, 37, 38]. Recently, statistically significant differences in the ratio of HbGA/HbAA between vegetarians and non-vegetarians have been reported, suggesting that dietary factors may also contribute to acrylamide/glycidamide metabolism [39]. …”

Section: Discussionsupporting

confidence: 80%

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

et al. 2016

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Purpose Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from 8 countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by HPLC/MS/MS (high-performance liquid chromatography/tandem mass spectrometry). In this cross-sectional analysis four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA+HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA), and all independent variables were log-transformed (log2) to improve normality. Median (25th-75thpercentile) HbAA and HbGA adducts levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. Results The main food group determinants of HbAA, HbGA, HbAA+HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA explained in this study was 30%, 26%, 29%, and 13%, respectively. Conclusions Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.

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Section: Discussionsupporting

confidence: 80%

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

et al. 2016

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“…Boxes, Perc 25/75; whisker, standard deviation; black squares, mean; dash, median; times symbol, minimum; asterisk, maximum; n.q. not quantified (due to no permission) blood reticulocytes of vegetarians (defined by excluding meat and fish from their diet) as compared to non-vegetarians, no significant difference in mean Hb adduct levels of AA and GA were found (Kotova et al 2015). The methodology applied in that study is, however, not comparable to our approach.…”

Section: Discussionmentioning

confidence: 79%

Biomonitoring of nutritional acrylamide intake by consumers without dietary preferences as compared to vegans

et al. 2019

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Acrylamide (AA) is a heat-induced food contaminant considered as genotoxic carcinogen. The present study investigated the influence of nutritional and lifestyle preferences on human AA exposure. A 10-day human study was performed with ten volunteers without nutritional preferences (omnivores) and ten vegans. Volunteers self-reported their daily routine and dietary habits. Overall mean AA intake, calculated from contents of diet duplicates, was 0.32 ± 0.19 µg/kg body weight (bw)/day with marked inter-day and inter-volunteer variabilities. Vegans ingested more AA (0.38 ± 0.23 µg/kg bw/day) than omnivore volunteers without dietary restrictions (0.26 ± 0.10 µg/kg bw/day). Excretion kinetics of urinary AA-related mercapturic acids N-acetyl-S-(2-carbamoylethyl)-l-cysteine and N-acetyl-S-(2-hydroxy-2-carbamoylethyl)-l-cysteine were essentially concordant with the respective dietary AA intake. Disproportionately enhanced AA-related biomarker excretion could be traced back to reportedly inadvertent, passive exposure to tobacco and/or fire smoke, as evidenced by the respective urinary exposure biomarkers, cotinine and N-acetyl-S-(2-cyanoethyl)-l-cysteine. Although the study is based on the comparison of small volunteer groups, the results confirm the association of AA exposure biomarkers with documented dietary preferences and lifestyle factors. Some additional contribution of endogenous background AA exposure was demonstrated individually. Disproportionately enhanced AA exposure is suggested to result from passive exposure to tobacco and/or barbecue smoke.

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“…In the 20th century, cancer incidence (after correction for age) has increased worldwide (534)(535)(536) in parallel with the spread of western technology, pollution and consumer products (181,182,537) and some cancers can be regarded as diseases of affluence. Lifestyle factors including diet, smoking and lack of exercise probably contribute importantly to the risk of cancer in a large part of the population of the more developed countries, but exposure to carcinogens or co-carcinogens present in polluted air and drinking water, as well as in food, is also thought to contribute significantly.…”

Section: Discussionmentioning

confidence: 99%

Causes of genome instability: the effect of low dose chemical exposures in modern society

Langie¹,

Koppen²,

Desaulniers

et al. 2015

CARCIN

174

114

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Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis.

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Differences in micronucleus frequency and acrylamide adduct levels with hemoglobin between vegetarians and non-vegetarians

Cited by 24 publications

References 40 publications

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Biomonitoring of nutritional acrylamide intake by consumers without dietary preferences as compared to vegans

Causes of genome instability: the effect of low dose chemical exposures in modern society

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