Manifestaciones cutáneas en donantes de sangre portadores de HTLV-1 en comparación con donantes de sangre no portadores de HTLV-1

García-Huidobro, Isidora; Cárdenas, Consuelo; Molgó, Montserrat; González, Sergio

doi:10.4067/s0034-98872014000700006

Cited by 2 publications

(9 citation statements)

References 29 publications

(32 reference statements)

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“…Erythematous‐squamous lesions were the most prevalent in this study (45.26%), possibly because they are almost always found in individuals with inflammatory diseases related to HTLV, and such group of diseases was the most frequent (64.2%). In the study by García‐Huidobro et al ., in Chile, the group of cutaneous manifestations most frequent in patients with HTLV‐1 were noninfectious inflammatory diseases (76%), and xerosis/ichthyosis was the most frequent inflammatory manifestation found in 40% of the cases, followed by seborrheic dermatitis and eczema, both with 28% prevalence, likewise in the study by Okajima et al . and Dantas et al ., both performed in Brazil, where xerosis/ichthyosis was the most frequent dermatological finding (49% and 44.13%, respectively), followed by seborrheic dermatitis (27% and 24%, respectively).…”

Section: Discussionmentioning

confidence: 76%

“…Skin lesions are common in individuals infected with HTLV‐1, both in asymptomatic and in those who have developed associated disease and may represent a warning sign for the diagnosis of infection . In a study carried out in Chile, it was found that HTLV‐1 positive blood donors had more dermatological alterations than the control group, which did not carry the virus, with a prevalence of 96% in the cases . In the other two investigations carried out in Brazil, high rates of dermatological diseases in HTLV‐1 positive individuals have also been reported .…”

Section: Discussionmentioning

confidence: 99%

“…This fact suggests that HTLV‐2 infection can also trigger cutaneous manifestations. Other studies included only HTLV‐1 infected individuals in their methodology …”

Section: Discussionmentioning

confidence: 99%

“…and Dantas et al ., both performed in Brazil, where xerosis/ichthyosis was the most frequent dermatological finding (49% and 44.13%, respectively), followed by seborrheic dermatitis (27% and 24%, respectively). Theoretically, the higher prevalence of xerosis/ichthyosis in this population is because of the damage of the eccrine gland by a lymphocytic inflammatory infiltrate and by the alteration of the autonomic regulation of the glands because of neuronal damage; this last one happens in patients with HAM/TSP, so the presence of acquired ichthyosis or acute xerosis in seropositive patients should serve as an early warning to the clinician of the possibility of further progression to HAM/TSP …”

Section: Discussionmentioning

confidence: 99%

“…In more than two‐thirds of ATLL cases, there is cutaneous involvement and may be the first clinical manifestation in one‐third of cases. The lesions found are very variable and may be macules, papules, and nodules, among others …”

Section: Introductionmentioning

confidence: 99%

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Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

et al. 2019

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Introduction Individuals infected with the human T‐cell lymphotropic virus type 1 (HTLV‐1) commonly present skin lesions, which may be a warning sign for the diagnosis of infection. This study describes the most prevalent skin manifestations in HTLV carriers attended at the clinic of Núcleo de Medicina Tropical (NMT) of the Universidade Federal do Pará (UFPA) in Belém, Pará, Brazil. Methods This is a study of a series of cases of patients infected with human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) treated at NMT UFPA between 1999 and 2016. A descriptive analysis of data was applied. Results Among 788 surveyed medical records in the service, 15.10% (n = 119) were referred to the dermatology clinic. From the series of cases that presented with skin lesions, 66.39% were female and 33.61% were male, and the average age of this group was 48 years. There was a predominance of patients with noninfectious inflammatory manifestations (64.2%), followed by infectious ones (24.6%), and 1.58% with lymphoproliferative diseases. As for the group of lesions, 45.26% of the erythematous‐squamous type were observed, followed by dyschromia (24.21%), and eczematous (14.74%). One patient with a diagnosis of adult T‐cell leukemia/lymphoma, another with parapsoriasis, and four with infective dermatitis are highlighted. Conclusion Skin disorders in the HLTV positive patient are important causes of referral to the dermatologist with etiological and skin lesions groups diversity. In the series of cases studied, lymphoproliferatives diseases and infective dermatitis associated with HTLV‐1 were presented as a challenge for the diagnosis and clinical management of these patients.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

“…This fact suggests that HTLV‐2 infection can also trigger cutaneous manifestations. Other studies included only HTLV‐1 infected individuals in their methodology …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

et al. 2019

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Palmo-plantar hyperkeratosis associated with HTLV-1 infection: a case report

et al. 2021

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Background Palmoplantar hyperkeratosis is a cutaneous manifestation that had not been clearly associated with infection by the human T-cell lymphotropic virus, which is a retrovirus that in most cases does not develop clinical pathologies and its symptoms may be undetected. The skin is one of the most affected organs, however until now only seborrheic dermatitis, xerosis/ichthyosis and infective dermatitis associated with HTLV-1 have been described as cutaneous clinical manifestations of this disease. Case presentation We present the case of a 36-year-old male patient with serologically documented HTLV-1 infection, who presented symptoms of diarrhea, malabsorption due to Strongyloides stercoralis, and in whom a physical examination revealed an association with generalized xerosis and palmoplantar keratoderma confirmed by skin biopsy. Other infectious etiologies and malignancy were ruled out. This clinical manifestation was managed with dermal hydration, and skin care which improved the thickened skin and make it less noticeable. Conclusions According to our experience, this is the first reported case of palmoplantar keratoderma associated with a human lymphotropic virus infection. This is a skin manifestation that has not been confirmed in conjunction with HTLV-I before. This implies that palmoplantar keratoderma is a new clinical manifestation of this infection, that should be considered in the initial approach of patients in endemic areas with these dermatological characteristics.

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Manifestaciones cutáneas en donantes de sangre portadores de HTLV-1 en comparación con donantes de sangre no portadores de HTLV-1

Abstract: (Rev Med Chile 2014; 142: 859-866)

Cited by 2 publications

References 29 publications

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

Palmo-plantar hyperkeratosis associated with HTLV-1 infection: a case report

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