Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma

Honarpisheh, Hedieh; Glusac, Earl J.; Ko, Christine J.

doi:10.1111/cup.12410

Cited by 22 publications

(20 citation statements)

References 21 publications

(42 reference statements)

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“…One report described colonizing CK20 þ Merkel cells in infundibulocystic BCC as well as in BFH; therefore, there is uncertainty regarding the diagnostic utility of CK20 in this specific context. 75 …”

Section: Basaloid Follicular Hamartomamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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Section: Basaloid Follicular Hamartomamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…CK 20‐positive Merkel cells can also help to distinguish basaloid epidermal proliferations overlying dermatofibromas (with Merkel cells) from BCC (without them) . In fact, the evidence of Merkel cells in infundibulocystic BCC is considered by some as a relevant proof of its hamartomatous nature …”

Section: Discussionmentioning

confidence: 99%

Merkel cells in extraocular sebaceous carcinoma

Fernández-Flores

2018

J Cutan Pathol

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Introduction Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid‐like or labyrinthine pattern can contain intratumoral Merkel cells. Our purpose in this study is to examine for the presence of Merkel cells in extraocular sebaceous carcinomas. Methods Nineteen cases of extraocular sebaceous carcinoma were retrospectively studied with cytokeratin 20. Results One out of 19 cases (5.3%) contained Merkel cells in the basal layers of the tumoral nests of a sebaceous carcinoma from the cheek of a 76‐year‐old woman. Conclusions Merkel cells are rarely evident in extraocular sebaceous carcinoma, and therefore, their evidence does not exclude this diagnosis.

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“…CK20 is a 46‐kDa intermediate filament protein, a type I keratin. CK20 labeling of MCs has generally been reported to be a useful marker for distinguishing basaloid tumors including CL (CK20‐positive cells present) from BCC (CK20‐positive cells absent); however, some authors have reported the presence of scattered CK20‐positive cells in BCC . Hence, we elected to study CK20 expression pattern in our cases of CL and BCC, to determine if it is a sensitive and specific differentiator.…”

Section: Discussionmentioning

confidence: 99%

“…CK20 labeling of MCs has generally been reported to be a useful marker for distinguishing basaloid tumors including CL (CK20-positive cells present) from BCC (CK20-positive cells absent); 8,10,11 however, some authors have reported the presence of scattered CK20-positive cells in BCC. 27,28 Hence, we elected to study CK20 expression pattern in our cases of CL and BCC, to determine if it is a sensitive and specific differentiator. CK20 immunohistochemical staining patterns revealed intratumoral CK20-positive MC in 36.4% of CL and in none of the BCC tissue samples (p = 0.012).…”

Section: Discussionmentioning

confidence: 99%